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Rotorua, hydrogen sulphide and Parkinson's disease-A possible beneficial link?

Abstract Rotorua city (New Zealand) is known for its 'rotten egg' smell, due to high levels of hydrogen sulphide (H2S) concentrations emitted from local geothermal vents. Studies have shown H2S as potentially toxic if too high in concentration. However, some health benefits have been observed at lower concentrations. This article summarises what is known about effects of H2S on health and postulates whether ambient air inhalation levels of H2S in Rotorua might have a therapeutic role in the management of motor symptoms in Parkinson's disease (PD).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the new zealand medical journal
Publication Year Start




PMID- 28494485
OWN - NLM
STAT- MEDLINE
DA  - 20170511
DCOM- 20170518
LR  - 20170518
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 130
IP  - 1455
DP  - 2017 May 12
TI  - Rotorua, hydrogen sulphide and Parkinson's disease-A possible beneficial link?
PG  - 123-125
AB  - AIM: Rotorua city (New Zealand) is known for its 'rotten egg' smell, due to high 
      levels of hydrogen sulphide (H2S) concentrations emitted from local geothermal
      vents. Studies have shown H2S as potentially toxic if too high in concentration. 
      However, some health benefits have been observed at lower concentrations. This
      article summarises what is known about effects of H2S on health and postulates
      whether ambient air inhalation levels of H2S in Rotorua might have a therapeutic 
      role in the management of motor symptoms in Parkinson's disease (PD). RESULTS:
      Chronic H2S inhalation has been shown to have a protective factor on dopaminergic
      neurons of animal models of PD. A large-scale survey of long-term Rotorua
      residents showed no evidence of health detriment nor impairment of cognitive
      functions. Intriguingly, however, participants in higher H2S exposures showed a
      tendency for faster motor response times in a finger tapping test. One of the PD 
      Motor Rating Scale examination tests for PD is finger tapping speed, as this is
      associated with motor performance. Might it be that relatively high, but safe,
      H2S levels in Rotorua could help protect the degradation of dopaminergic neurons 
      associated with PD? CONCLUSION: An observed beneficial link between chronic H2S
      inhalation in PD animal models and improved finger tapping scores in a sample of 
      the Rotorua population, linked to dopaminergic nerve function, is worth
      investigating further.
FAU - Cakmak, Yusuf O
AU  - Cakmak YO
AD  - Senior Lecturer, Otago University, School of Medicine, Department of Anatomy,
      Dunedin.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170512
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
RN  - 0 (Air Pollutants)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Air Pollutants/*pharmacology
MH  - Animals
MH  - Humans
MH  - Hydrogen Sulfide/*pharmacology
MH  - Models, Animal
MH  - New Zealand/epidemiology
MH  - Parkinson Disease/*drug therapy
COI - Nil.
EDAT- 2017/05/12 06:00
MHDA- 2017/05/19 06:00
CRDT- 2017/05/12 06:00
PST - epublish
SO  - N Z Med J. 2017 May 12;130(1455):123-125.

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