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Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study).

Abstract Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD). Children included in the study were divided into: group 1, patients with confirmed CD; group 2, patients with "potential' CD; group 3, control group, patients without CD. We assessed the standard laboratory data, the level of TG2/DGP and EMA antibodies, as well as the distribution of HLA molecules in the selected patients. Histopathological examination was considered the criterion standard for diagnosis in most cases.The sensitivity of TG2/DGP was 85% and the specificity 92%. EMA showed a sensitivity of 82% and a specificity of 98%. The vast majority of patients diagnosed with CD were either HLA-DQ2.5 (encoded by DQA1*05 & DQB1*02) positive (87.5%) or HLA-DQ8 (encoded by DQB1*03:02) positive (12.5%). One patient showed a positivity only for HLA-DQ2.2 (encoded by DQA1*02 & B1*02).Our study showed that the genetic risk for CD was present in more than one-third of the cases without a confirmed diagnosis of CD. Therefore, the awareness of genetic susceptibility for CD is essential because of the fact that these individuals can develop the disease at any point of their lives. The sensitivity of TG2/DGP and EMA were very similar, whereas EMA presented a higher specificity as that of TG2/DGP.
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Journal Title medicine
Publication Year Start




PMID- 28514313
OWN - NLM
STAT- In-Process
DA  - 20170517
LR  - 20170517
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 20
DP  - 2017 May
TI  - Clinical and biological correlations in celiac disease in children: the
      prospective single experience of a romanian tertiary center: A case-control study
      (Strobe-Compliant study).
PG  - e6936
LID - 10.1097/MD.0000000000006936 [doi]
AB  - Celiac disease-a chronic inflammatory disease of the intestine-is triggered by
      gluten or associated protein consumption.The aim of our study was to assess the
      sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated
      gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to
      determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also
      to evaluate the clinical and laboratory characteristics of patients admitted with
      the suspicion of celiac disease (CD). Children included in the study were divided
      into: group 1, patients with confirmed CD; group 2, patients with "potential' CD;
      group 3, control group, patients without CD. We assessed the standard laboratory 
      data, the level of TG2/DGP and EMA antibodies, as well as the distribution of HLA
      molecules in the selected patients. Histopathological examination was considered 
      the criterion standard for diagnosis in most cases.The sensitivity of TG2/DGP was
      85% and the specificity 92%. EMA showed a sensitivity of 82% and a specificity of
      98%. The vast majority of patients diagnosed with CD were either HLA-DQ2.5
      (encoded by DQA1*05 & DQB1*02) positive (87.5%) or HLA-DQ8 (encoded by
      DQB1*03:02) positive (12.5%). One patient showed a positivity only for HLA-DQ2.2 
      (encoded by DQA1*02 & B1*02).Our study showed that the genetic risk for CD was
      present in more than one-third of the cases without a confirmed diagnosis of CD. 
      Therefore, the awareness of genetic susceptibility for CD is essential because of
      the fact that these individuals can develop the disease at any point of their
      lives. The sensitivity of TG2/DGP and EMA were very similar, whereas EMA
      presented a higher specificity as that of TG2/DGP.
FAU - Marginean, Cristina Oana
AU  - Marginean CO
AD  - aDepartment of Pediatrics bDepartment of Epidemiology cDepartment of Laboratory
      Medicine, University of Medicine and Pharmacy Tirgu Mures, Romania.
FAU - Melit, Lorena Elena
AU  - Melit LE
FAU - Mares, Roxana-Cristina
AU  - Mares RC
FAU - Marginean, Maria Oana
AU  - Marginean MO
FAU - Voidazan, Septimiu
AU  - Voidazan S
FAU - Dobreanu, Minodora
AU  - Dobreanu M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
CRDT- 2017/05/18 06:00
AID - 10.1097/MD.0000000000006936 [doi]
AID - 00005792-201705190-00030 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(20):e6936. doi: 10.1097/MD.0000000000006936.

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