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Role of Cystatin C and glomerular filtration rate in diagnosis of kidney impairment in hepatic cirrhosis patients.

Abstract Hepatic cirrhosis is often accompanied by functional kidney impairment, which may be reversed if early treatment is promptly administered. This study aimed to investigate the role of Cystatin C and Cystatin C estimated glomerular filtration rate in the diagnosis of kidney impairment in patients with hepatic cirrhosis.Four hundred sixty five patients with hepatic cirrhosis were recruited. Serum creatinine and Cystatin C were determined, and their estimated glomerular filtration rates were calculated.The area under the receiver-operating characteristic curve (area under curve [AUC]) of Cystatin C and Cystatin C estimated glomerular filtration rate was significantly larger than that of serum creatinine and serum creatinine estimated glomerular filtration rate, respectively (P = .000). When the optimal cut-off value and upper reference limit were used, similar sensitivity, misdiagnosis rate, and diagnostic consistency were only observed in Cystatin C estimated glomerular filtration rate (P > .05).Cystatin C and Cystatin C estimated glomerular filtration rate are superior to serum creatinine and serum creatinine estimated glomerular filtration rate in diagnosis of secondary kidney impairment, and Cystatin C estimated glomerular filtration rate has a better performance as compared with Cystatin C. However, it is not a measured parameter, and thus the lab should determine its own optimal cut-off value.
PMID
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Authors

Mayor MeshTerms

Glomerular Filtration Rate

Keywords
Journal Title medicine
Publication Year Start




PMID- 28514315
OWN - NLM
STAT- MEDLINE
DA  - 20170517
DCOM- 20170613
LR  - 20170613
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 20
DP  - 2017 May
TI  - Role of Cystatin C and glomerular filtration rate in diagnosis of kidney
      impairment in hepatic cirrhosis patients.
PG  - e6949
LID - 10.1097/MD.0000000000006949 [doi]
AB  - Hepatic cirrhosis is often accompanied by functional kidney impairment, which may
      be reversed if early treatment is promptly administered. This study aimed to
      investigate the role of Cystatin C and Cystatin C estimated glomerular filtration
      rate in the diagnosis of kidney impairment in patients with hepatic
      cirrhosis.Four hundred sixty five patients with hepatic cirrhosis were recruited.
      Serum creatinine and Cystatin C were determined, and their estimated glomerular
      filtration rates were calculated.The area under the receiver-operating
      characteristic curve (area under curve [AUC]) of Cystatin C and Cystatin C
      estimated glomerular filtration rate was significantly larger than that of serum 
      creatinine and serum creatinine estimated glomerular filtration rate,
      respectively (P = .000). When the optimal cut-off value and upper reference limit
      were used, similar sensitivity, misdiagnosis rate, and diagnostic consistency
      were only observed in Cystatin C estimated glomerular filtration rate (P >
      .05).Cystatin C and Cystatin C estimated glomerular filtration rate are superior 
      to serum creatinine and serum creatinine estimated glomerular filtration rate in 
      diagnosis of secondary kidney impairment, and Cystatin C estimated glomerular
      filtration rate has a better performance as compared with Cystatin C. However, it
      is not a measured parameter, and thus the lab should determine its own optimal
      cut-off value.
FAU - Wang, Dong
AU  - Wang D
AD  - aDepartment of General Surgery bDepartment of Clinical Laboratory cDepartment of 
      Pathology, Mianyang Central Hospital, Affiliated to Southwest Medical University,
      Sichuan Province, China.
FAU - Feng, Jia-Fu
AU  - Feng JF
FAU - Wang, An-Qun
AU  - Wang AQ
FAU - Yang, Yu-Wei
AU  - Yang YW
FAU - Liu, Yun-Shuang
AU  - Liu YS
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Biomarkers/metabolism
MH  - Creatinine/blood
MH  - Cystatin C/*blood
MH  - Diagnostic Errors
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Liver Cirrhosis/*complications/metabolism
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Renal Insufficiency/*etiology/*metabolism
MH  - Young Adult
PMC - PMC5440152
EDAT- 2017/05/18 06:00
MHDA- 2017/06/14 06:00
CRDT- 2017/05/18 06:00
AID - 10.1097/MD.0000000000006949 [doi]
AID - 00005792-201705190-00032 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(20):e6949. doi: 10.1097/MD.0000000000006949.