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Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa.

Abstract The paper presents an example of differential diagnostic studies for pyogenic granuloma and oral squamous cell carcinoma (SCC). In the described case immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional histological procedure proved to be inconvenient for adequate diagnostics. The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title stomatologiia
Publication Year Start




PMID- 28514345
OWN - NLM
STAT- MEDLINE
DA  - 20170517
DCOM- 20170707
LR  - 20170707
IS  - 0039-1735 (Print)
IS  - 0039-1735 (Linking)
VI  - 96
IP  - 2
DP  - 2017
TI  - [Immunohistochemical criteria for differential diagnostics of squamous epithelium
      changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa].
PG  - 33-35
LID - 10.17116/stomat201796233-35 [doi]
AB  - The paper presents an example of differential diagnostic studies for pyogenic
      granuloma and oral squamous cell carcinoma (SCC). In the described case
      immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional
      histological procedure proved to be inconvenient for adequate diagnostics. The
      immunohistochemical study established increased proliferative activity of
      epithelial cells specific both pyogenic granuloma and oral SCC, but intensive
      Gli1 protein expression in membranes and cytoplasm of epithelial cells with
      malignant transformation allowed differentiation of these neoplasms.
FAU - Ivina, A A
AU  - Ivina AA
AD  - Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow,
      Russia; Peoples' Friendship University of Russia, Moscow, Russia.
FAU - Semkin, V A
AU  - Semkin VA
AD  - Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow,
      Russia.
FAU - Babichenko, I I
AU  - Babichenko II
AD  - Peoples' Friendship University of Russia, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Immunogistokhimicheskie kriterii differentsial'noi diagnostiki ploskogo epiteliia
      pri piogennoi granuleme i ploskokletochnom rake slizistoi obolochki rta.
PL  - Russia (Federation)
TA  - Stomatologiia (Mosk)
JT  - Stomatologiia
JID - 0412072
RN  - 0 (Antibodies)
RN  - 0 (GLI1 protein, human)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Zinc Finger Protein GLI1)
SB  - D
SB  - IM
MH  - Antibodies/immunology
MH  - Carcinoma, Squamous Cell/chemistry/*diagnosis/pathology
MH  - Cell Membrane/chemistry
MH  - Cell Transformation, Neoplastic/chemistry/pathology
MH  - Diagnosis, Differential
MH  - Granuloma, Pyogenic/*diagnosis/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/*analysis/immunology
MH  - Mouth Mucosa/chemistry/pathology
MH  - Mouth Neoplasms/chemistry/*diagnosis/pathology
MH  - Zinc Finger Protein GLI1/*analysis/immunology
EDAT- 2017/05/18 06:00
MHDA- 2017/07/08 06:00
CRDT- 2017/05/18 06:00
PST - ppublish
SO  - Stomatologiia (Mosk). 2017;96(2):33-35. doi: 10.17116/stomat201796233-35.