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IgG4-related sclerosing disease of the larynx.

Abstract IgG4-related sclerosing disease of the larynx (IgG4-SD) is a recently described immunodependent systemic pathology characterized by diffusive or focal inflammatory infiltration of the affected organs and tissues by plasma cells expressing IgG4; it is accompanied by the subsequent development of obliterative phlebitis and fibrosclerosis associated with the increase of the serum IgG4 level. According to the recently published materials, the disease can also develop in the respiratory system. The present article describes the first documented case of IgG4-related sclerosing disease with the isolated lesion of the larynx. The diagnosis was established based on the results of the comprehensive examination that made it possible to exclude systemic lesions, to determine the IgG4 level in the serum, and to carry out the immunohistochemical study of the histological preparations stained for the detection of IgG4-releasing plasmocytes. After verification of the diagnosis, the patient underwent a course of systemic hormonal therapy that resulted in the stable clinical and roentgenological remission of the disease that persists up to the present time.
PMID
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Authors

Mayor MeshTerms

Laryngostenosis

Sclerosis

Keywords
Journal Title vestnik otorinolaringologii
Publication Year Start




PMID- 28514371
OWN - NLM
STAT- MEDLINE
DA  - 20170517
DCOM- 20170710
LR  - 20170713
IS  - 0042-4668 (Print)
IS  - 0042-4668 (Linking)
VI  - 82
IP  - 2
DP  - 2017
TI  - [IgG4-related sclerosing disease of the larynx].
PG  - 77-79
LID - 10.17116/otorino201782277-79 [doi]
AB  - IgG4-related sclerosing disease of the larynx (IgG4-SD) is a recently described
      immunodependent systemic pathology characterized by diffusive or focal
      inflammatory infiltration of the affected organs and tissues by plasma cells
      expressing IgG4; it is accompanied by the subsequent development of obliterative 
      phlebitis and fibrosclerosis associated with the increase of the serum IgG4
      level. According to the recently published materials, the disease can also
      develop in the respiratory system. The present article describes the first
      documented case of IgG4-related sclerosing disease with the isolated lesion of
      the larynx. The diagnosis was established based on the results of the
      comprehensive examination that made it possible to exclude systemic lesions, to
      determine the IgG4 level in the serum, and to carry out the immunohistochemical
      study of the histological preparations stained for the detection of
      IgG4-releasing plasmocytes. After verification of the diagnosis, the patient
      underwent a course of systemic hormonal therapy that resulted in the stable
      clinical and roentgenological remission of the disease that persists up to the
      present time.
FAU - Mustafaev, D M
AU  - Mustafaev DM
AD  - M.F. Vladimirov Moscow Regional Research Clinical Institute, Moscow, Rusia,
      129110.
LA  - rus
PT  - Case Reports
PT  - Journal Article
TT  - IgG4-sviazannaia skleroziruiushchaia bolezn' gortani.
PL  - Russia (Federation)
TA  - Vestn Otorinolaringol
JT  - Vestnik otorinolaringologii
JID - 0416577
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Disease Management
MH  - Humans
MH  - Immune System Diseases/diagnosis/immunology/pathology
MH  - Immunoglobulin G/*immunology
MH  - *Laryngostenosis/diagnosis/immunology/pathology
MH  - Larynx/diagnostic imaging/pathology
MH  - Male
MH  - *Sclerosis/diagnosis/immunology/pathology
MH  - Tomography, X-Ray Computed/methods
EDAT- 2017/05/18 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/05/18 06:00
PST - ppublish
SO  - Vestn Otorinolaringol. 2017;82(2):77-79. doi: 10.17116/otorino201782277-79.