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A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein.

Abstract Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA.
PMID
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Authors

Mayor MeshTerms
Keywords

biomarker

canine osteoarthritis

extra-cellular matrix

proteomix analysis

synovial fluid

Journal Title polish journal of veterinary sciences
Publication Year Start




PMID- 28525322
OWN - NLM
STAT- MEDLINE
DA  - 20170519
DCOM- 20170629
LR  - 20170629
IS  - 1505-1773 (Print)
IS  - 1505-1773 (Linking)
VI  - 20
IP  - 1
DP  - 2017 Mar 28
TI  - A systemic review of existing serological possibilities to diagnose canine
      osteoarthritis with a particular focus on extracellular matrix proteoglycans and 
      protein.
PG  - 189-201
LID - 10.1515/pjvs-2017-0024 [doi]
LID - /j/pjvs.2017.20.issue-1/pjvs-2017-0024/pjvs-2017-0024.xml [pii]
AB  - Extra-cellular matrix (ECM) components are important and their stabilization is
      significant in maintaining normal healthy joint environment. In osteoarthritis
      (OA), ECM components are altered and indicate disease progression. The joint ECM 
      is composed of proteoglycans (aggrecan, perlecan, inter alpha-trypsin inhibitor),
      glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly
      collagen type II) which represent structural and functional transformation during
      disease advancement. ECM investigation revealed significant biomarkers of OA that
      could be used as a diagnostic and therapeutic tool in different canine orthopedic
      diseases. This review deliberates our current findings of how the components of
      ECM change at the molecular level during disease progression in canine OA.
FAU - Shahid, M
AU  - Shahid M
AD  - .
FAU - Manchi, G
AU  - Manchi G
AD  - .
FAU - Slunsky, P
AU  - Slunsky P
AD  - .
FAU - Naseer, O
AU  - Naseer O
AD  - .
FAU - Fatima, A
AU  - Fatima A
AD  - .
FAU - Leo, B
AU  - Leo B
AD  - .
FAU - Raila, J
AU  - Raila J
AD  - .
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Pol J Vet Sci
JT  - Polish journal of veterinary sciences
JID - 101125473
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Proteoglycans)
SB  - IM
MH  - Animals
MH  - Dog Diseases/*metabolism
MH  - Dogs
MH  - Extracellular Matrix Proteins/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Osteoarthritis/metabolism/*veterinary
MH  - Proteoglycans/genetics/*metabolism
OTO - NOTNLM
OT  - biomarker
OT  - canine osteoarthritis
OT  - extra-cellular matrix
OT  - proteomix analysis
OT  - synovial fluid
EDAT- 2017/05/20 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/05/20 06:00
AID - 10.1515/pjvs-2017-0024 [doi]
AID - /j/pjvs.2017.20.issue-1/pjvs-2017-0024/pjvs-2017-0024.xml [pii]
PST - ppublish
SO  - Pol J Vet Sci. 2017 Mar 28;20(1):189-201. doi: 10.1515/pjvs-2017-0024.