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An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers.

Abstract Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous gland carcinoma samples which were accompanied by a lymphocytic infiltration and/or secondary lymphatic follicles were verified histopathologically. The expression of bcl-2, CD3, CD79α, Ki-67, MCM-3 and MCM-7 in the lymphocytic infiltration was evaluated. Four types of lymphocytic infiltrations were found: I - diffuse bcl-2+, II - diffuse bcl-2-, III - follicular bcl-2+/- where the centre was bcl-2-, and the marginal zone of the follicles and the extrafollicular area were bcl-2+ and IV - aggregated bcl-2+, where the centre and periphery were bcl-2+. The I and IV type corresponds to lymphoma, II type is non-neoplastic immune response and III type suggest reactive follicular hyperplasia. The proliferation of lymphocytes which demonstrated the expression of neoplastic markers (I and IV), suggests preneoplastic phase (pseudolymphoma) or lymphoma - the second independent tumour. A high proliferative index of the follicular blc-2+/- follicular infiltration indicates an increased immunological response of the host against skin cancer.
PMID
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Authors

Mayor MeshTerms
Keywords

bcl-2

dog

lymphocytic infiltration

lymphoma

skin cancer

Journal Title polish journal of veterinary sciences
Publication Year Start




PMID- 28525331
OWN - NLM
STAT- In-Process
DA  - 20170519
LR  - 20170523
IS  - 1505-1773 (Print)
IS  - 1505-1773 (Linking)
VI  - 20
IP  - 1
DP  - 2017 Mar 28
TI  - An immunohistochemical analysis of lymphocytic infiltrations in canine skin
      cancers.
PG  - 141-147
LID - 10.1515/pjvs-2017-0018 [doi]
LID - /j/pjvs.2017.20.issue-1/pjvs-2017-0018/pjvs-2017-0018.xml [pii]
AB  - Lymphocytic infiltrations located in the extracellular matrix often accompany
      canine skin cancer. They can be characterised as an inflammatory infiltration
      and/or a second tumour - lymphoma. The aim of this study was an
      immunohistochemical analysis of a lymphocytic infiltration which accompanies
      spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing
      squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous 
      gland carcinoma samples which were accompanied by a lymphocytic infiltration
      and/or secondary lymphatic follicles were verified histopathologically. The
      expression of bcl-2, CD3, CD79alpha, Ki-67, MCM-3 and MCM-7 in the lymphocytic
      infiltration was evaluated. Four types of lymphocytic infiltrations were found: I
      - diffuse bcl-2+, II - diffuse bcl-2-, III - follicular bcl-2+/- where the centre
      was bcl-2-, and the marginal zone of the follicles and the extrafollicular area
      were bcl-2+ and IV - aggregated bcl-2+, where the centre and periphery were
      bcl-2+. The I and IV type corresponds to lymphoma, II type is non-neoplastic
      immune response and III type suggest reactive follicular hyperplasia. The
      proliferation of lymphocytes which demonstrated the expression of neoplastic
      markers (I and IV), suggests preneoplastic phase (pseudolymphoma) or lymphoma -
      the second independent tumour. A high proliferative index of the follicular
      blc-2+/- follicular infiltration indicates an increased immunological response of
      the host against skin cancer.
FAU - Madej, J A
AU  - Madej JA
AD  - .
FAU - Madej, J P
AU  - Madej JP
AD  - .
FAU - Dzimira, S
AU  - Dzimira S
AD  - .
FAU - Nowak, M
AU  - Nowak M
AD  - .
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pol J Vet Sci
JT  - Polish journal of veterinary sciences
JID - 101125473
OTO - NOTNLM
OT  - bcl-2
OT  - dog
OT  - lymphocytic infiltration
OT  - lymphoma
OT  - skin cancer
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:00
CRDT- 2017/05/20 06:00
AID - 10.1515/pjvs-2017-0018 [doi]
AID - /j/pjvs.2017.20.issue-1/pjvs-2017-0018/pjvs-2017-0018.xml [pii]
PST - ppublish
SO  - Pol J Vet Sci. 2017 Mar 28;20(1):141-147. doi: 10.1515/pjvs-2017-0018.

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