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Morphological analysis of testicles in cats with disorders of sex development.

Abstract Disorders of sex development (DSD) are rare in cats. They can be caused by chromosomal aberrations, gene mutations or other undefined factors. The aim of the present study was to compare the histological structure and immunohistochemical reactivity of testes in cats with DSD and in healthy cats. The research material consisted of the gonads of four cats - phenotypic males with an incorrect structure of the reproductive system. The control group consisted of the testes of four healthy cats - routinely castrated phenotypical males. The material was fixed with formalin and embedded in paraffin; the sections were stained with hematoxylin and eosin. The immunohistochemical investigation were performed using monoclonal and polyclonal antibodies directed against desmin, vimentin, actin of smooth muscles, S100 protein and MCM3 protein. The results obtained allow concluding that the testes of cats with DSD differed in certain respects, mainly in the number of blood vessels, from the normal testes. Moreover, the results of immunohistochemical examination indicate that in the testes of cats with DSD the number of supporting cells is lower, the amount of interstitial cells is comparable and spermatogenesis is correct es compared to those determined in the control gonads. The number of blood vessels in cats with DSD is reduced by about 30%. It confirms the recommendations for castration of these animals in order to eliminate the potential inheritance of sex development disorders.
PMID
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Authors

Mayor MeshTerms
Keywords

cat

disorders of sex development

histopathology

immunohistochemistry

Journal Title polish journal of veterinary sciences
Publication Year Start




PMID- 28525341
OWN - NLM
STAT- MEDLINE
DA  - 20170519
DCOM- 20170629
LR  - 20170629
IS  - 1505-1773 (Print)
IS  - 1505-1773 (Linking)
VI  - 20
IP  - 1
DP  - 2017 Mar 28
TI  - Morphological analysis of testicles in cats with disorders of sex development.
PG  - 123-131
LID - 10.1515/pjvs-2017-0016 [doi]
LID - /j/pjvs.2017.20.issue-1/pjvs-2017-0016/pjvs-2017-0016.xml [pii]
AB  - Disorders of sex development (DSD) are rare in cats. They can be caused by
      chromosomal aberrations, gene mutations or other undefined factors. The aim of
      the present study was to compare the histological structure and
      immunohistochemical reactivity of testes in cats with DSD and in healthy cats.
      The research material consisted of the gonads of four cats - phenotypic males
      with an incorrect structure of the reproductive system. The control group
      consisted of the testes of four healthy cats - routinely castrated phenotypical
      males. The material was fixed with formalin and embedded in paraffin; the
      sections were stained with hematoxylin and eosin. The immunohistochemical
      investigation were performed using monoclonal and polyclonal antibodies directed 
      against desmin, vimentin, actin of smooth muscles, S100 protein and MCM3 protein.
      The results obtained allow concluding that the testes of cats with DSD differed
      in certain respects, mainly in the number of blood vessels, from the normal
      testes. Moreover, the results of immunohistochemical examination indicate that in
      the testes of cats with DSD the number of supporting cells is lower, the amount
      of interstitial cells is comparable and spermatogenesis is correct es compared to
      those determined in the control gonads. The number of blood vessels in cats with 
      DSD is reduced by about 30%. It confirms the recommendations for castration of
      these animals in order to eliminate the potential inheritance of sex development 
      disorders.
FAU - Dzimira, S
AU  - Dzimira S
AD  - .
FAU - Nizanski, W
AU  - Nizanski W
AD  - .
FAU - Madej, J A
AU  - Madej JA
AD  - .
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pol J Vet Sci
JT  - Polish journal of veterinary sciences
JID - 101125473
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - Cat Diseases/*pathology
MH  - Cats
MH  - Disorders of Sex Development/pathology/*veterinary
MH  - Karyotype
MH  - Male
MH  - Testis/*pathology
OTO - NOTNLM
OT  - cat
OT  - disorders of sex development
OT  - histopathology
OT  - immunohistochemistry
EDAT- 2017/05/20 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/05/20 06:00
AID - 10.1515/pjvs-2017-0016 [doi]
AID - /j/pjvs.2017.20.issue-1/pjvs-2017-0016/pjvs-2017-0016.xml [pii]
PST - ppublish
SO  - Pol J Vet Sci. 2017 Mar 28;20(1):123-131. doi: 10.1515/pjvs-2017-0016.