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Splenic marginal zone lymphoma.

Abstract Splenic marginal zone lymphoma (SMZL) is a rare B-cell lymphoma, well defined according to the 2016 WHO classification of tumors of the hematopoietic tissue, which can raise diagnostic problems. We report the case of a 72-year old patient, hospitalised for exploration of a massive splenomegaly confirmed by computed tomography (CT). Laboratory tests were normal. The patient underwent splenectomy. Microscopic examination of the surgical specimen showed widespread lymphomatous proliferation in small cells associated with CD20 marker. CD 5 and CD 43 were negative. The diagnosis of SMZL was retained. SMZL accounts for less than 2% of non-Hodgkin lymphomas. It affects subjects older than 50 years, and it is usually characterized by the presence of a massive splenomegaly without lymphadenopathies. Blood count shows inconsistent presence of villous lymphocytes in three quarters of cases. The diagnosis is essentially based on anatomopathological evaluation and shows constant nodular involvement or sometimes diffuse involvement of white pulp of the splenic parenchyma.Tumor cells are small in size with B lymphoid markers expression: CD19, CD20, CD22, CD79. They are negative for CD5, CD10, cyclin D1 and CD43. No specific cytogenetic abnormality in SMZL has been identified. SMZL is an indolent lymphoma whose treatment is not codified, depending on prognostic factors. Mortality is related to the risk of its transformation to large cell lymphoma.
PMID
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Authors

Mayor MeshTerms
Keywords

Splenic marginal zone lymphoma

indolent

prognosis

Journal Title the pan african medical journal
Publication Year Start




PMID- 28533834
OWN - NLM
STAT- In-Process
DA  - 20170523
LR  - 20170526
IS  - 1937-8688 (Electronic)
VI  - 26
DP  - 2017
TI  - [Splenic marginal zone lymphoma].
PG  - 111
LID - 10.11604/pamj.2017.26.111.11446 [doi]
AB  - Splenic marginal zone lymphoma (SMZL) is a rare B-cell lymphoma, well defined
      according to the 2016 WHO classification of tumors of the hematopoietic tissue,
      which can raise diagnostic problems. We report the case of a 72-year old patient,
      hospitalised for exploration of a massive splenomegaly confirmed by computed
      tomography (CT). Laboratory tests were normal. The patient underwent splenectomy.
      Microscopic examination of the surgical specimen showed widespread lymphomatous
      proliferation in small cells associated with CD20 marker. CD 5 and CD 43 were
      negative. The diagnosis of SMZL was retained. SMZL accounts for less than 2% of
      non-Hodgkin lymphomas. It affects subjects older than 50 years, and it is usually
      characterized by the presence of a massive splenomegaly without
      lymphadenopathies. Blood count shows inconsistent presence of villous lymphocytes
      in three quarters of cases. The diagnosis is essentially based on
      anatomopathological evaluation and shows constant nodular involvement or
      sometimes diffuse involvement of white pulp of the splenic parenchyma.Tumor cells
      are small in size with B lymphoid markers expression: CD19, CD20, CD22, CD79.
      They are negative for CD5, CD10, cyclin D1 and CD43. No specific cytogenetic
      abnormality in SMZL has been identified. SMZL is an indolent lymphoma whose
      treatment is not codified, depending on prognostic factors. Mortality is related 
      to the risk of its transformation to large cell lymphoma.
FAU - Mohamed, Sinaa
AU  - Mohamed S
AD  - Service d'Anatomie Pathologique, Hopital Militaire Moulay Ismail, Meknes, Maroc.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Lymphome a cellules de la zone marginale splenique.
DEP - 20170301
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
PMC - PMC5429422
OTO - NOTNLM
OT  - Splenic marginal zone lymphoma
OT  - indolent
OT  - prognosis
COI - Les auteurs ne declarent aucun conflit d'interets.
EDAT- 2017/05/24 06:00
MHDA- 2017/05/24 06:00
CRDT- 2017/05/24 06:00
PHST- 2016/12/19 [received]
PHST- 2017/02/18 [accepted]
AID - 10.11604/pamj.2017.26.111.11446 [doi]
AID - PAMJ-26-111 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Mar 1;26:111. doi: 10.11604/pamj.2017.26.111.11446.
      eCollection 2017.

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