PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars: A multicenter, randomized, double-blind, crossover, phase IV trial.

Abstract The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. This study aimed to evaluate the efficacy and safety of 2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of bilateral impacted mandibular third molars.
PMID
Related Publications

Effects of Two Different Anesthetic Solutions on Injection Pain, Efficacy, and Duration of Soft-Tissue Anesthesia with Inferior Alveolar Nerve Block for Primary Molars.

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study.

Hemodynamic changes comparing lidocaine HCl with epinephrine and articaine HCl with epinephrine.

Comparative study of the anesthetic efficacy of 4% articaine versus 2% lidocaine in inferior alveolar nerve block during surgical extraction of impacted lower third molars.

A prospective randomized double-blind study to assess the latency and efficacy of twin-mix and 2% lignocaine with 1:200,000 epinephrine in surgical removal of impacted mandibular third molars: a pilot study.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28538371
OWN - NLM
STAT- In-Process
DA  - 20170524
LR  - 20170524
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 21
DP  - 2017 May
TI  - Comparison of the efficacy and safety of 2% lidocaine HCl with different
      epinephrine concentration for local anesthesia in participants undergoing
      surgical extraction of impacted mandibular third molars: A multicenter,
      randomized, double-blind, crossover, phase IV trial.
PG  - e6753
LID - 10.1097/MD.0000000000006753 [doi]
AB  - BACKGROUND: The most commonly impacted tooth is the third molar. An impacted
      third molar can ultimately cause acute pain, infection, tumors, cysts, caries,
      periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for
      removing the third molar. This study aimed to evaluate the efficacy and safety of
      2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of
      bilateral impacted mandibular third molars. METHODS: Sixty-five healthy
      participants underwent surgical extraction of bilateral impacted mandibular third
      molars in 2 separate visits while under local anesthesia with 2% lidocaine with
      different epinephrine concentration (1:80,000 or 1:200,000) in a double-blind,
      randomized, crossover trial. Visual analog scale pain scores obtained immediately
      after surgical extraction were primarily evaluated for the 2 groups receiving
      different epinephrine concentrations. Visual analog scale pain scores were
      obtained 2, 4, and 6 hours after administering an anesthetic. Onset and duration 
      of analgesia, onset of pain, intraoperative bleeding, operator's and
      participant's overall satisfaction, drug dosage, and hemodynamic parameters were 
      evaluated for the 2 groups. RESULTS: There were no statistically significant
      differences between the 2 groups in any measurements except hemodynamic factors
      (P >.05). Changes in systolic blood pressure and heart rate following anesthetic 
      administration were significantly greater in the group receiving 1:80,000
      epinephrine than in that receiving 1:200,000 epinephrine (P </=.01). CONCLUSION: 
      The difference in epinephrine concentration between 1:80,000 and 1:200,000 in 2% 
      lidocaine liquid does not affect the medical efficacy of the anesthetic.
      Furthermore, 2% lidocaine with 1:200,000 epinephrine has better safety with
      regard to hemodynamic parameters than 2% lidocaine with 1:80,000 epinephrine.
      Therefore, we suggest using 2% lidocaine with 1:200,000 epinephrine rather than
      2% lidocaine with 1:80,000 epinephrine for surgical extraction of impacted
      mandibular third molars in hemodynamically unstable patients.
FAU - Karm, Myong-Hwan
AU  - Karm MH
AD  - aDepartment of Dental Anesthesiology bDepartment of Dental Anesthesiology and
      Dental Research Institute, Seoul National University School of Dentistry
      cDepartment of Oral & Maxillofacial Surgery, Yonsei University College of
      Dentistry, Seoul dDepartment of Dental Anesthesiology, Dankook University College
      of Dentistry, Dankook University, Cheonan-si, Chungnam eDepartment of Oral and
      Maxillofacial Surgery, School of Dentistry, Pusan National University and
      Institute of Translational Dental Sciences, Pusan National University fDepartment
      of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National
      University and Dental Research Institute, Pusan National University Dental
      Hospital, Yangsan, Gyeongnam gCollege of Dentistry, Wonkwang University, Iksan
      city, Jeonbuk hDepartment of Oral and Maxillofacial Surgery, Dankook University
      College of Dentistry, Dankook University, Cheonan-si, Chungnam iDepartment of
      Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital Kyung Hee
      University School of Dentistry, Seoul jR&D Center, Huons Co. Ltd., College of
      Pharmacy, Hanyang University, Ansan-si, Kyeonggi-do, Republic of Korea.
FAU - Park, Fiona Daye
AU  - Park FD
FAU - Kang, Moonkyu
AU  - Kang M
FAU - Kim, Hyun Jeong
AU  - Kim HJ
FAU - Kang, Jeong Wan
AU  - Kang JW
FAU - Kim, Seungoh
AU  - Kim S
FAU - Kim, Yong-Deok
AU  - Kim YD
FAU - Kim, Cheul-Hong
AU  - Kim CH
FAU - Seo, Kwang-Suk
AU  - Seo KS
FAU - Kwon, Kyung-Hwan
AU  - Kwon KH
FAU - Kim, Chul-Hwan
AU  - Kim CH
FAU - Lee, Jung-Woo
AU  - Lee JW
FAU - Hong, Sung-Woon
AU  - Hong SW
FAU - Lim, Mi Hyoung
AU  - Lim MH
FAU - Nam, Seung Kwan
AU  - Nam SK
FAU - Cho, Jae Min
AU  - Cho JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/05/26 06:00
MHDA- 2017/05/26 06:00
CRDT- 2017/05/25 06:00
AID - 10.1097/MD.0000000000006753 [doi]
AID - 00005792-201705260-00012 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(21):e6753. doi: 10.1097/MD.0000000000006753.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>