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Serum PLR and LMR in Behçet's disease: Can they show the disease activity?

Abstract The aim of this study is to determine platelet to lymphocyte ratio (PLR) and lymphocytes to monocytes ratio (LMR) levels in Behçet's disease (BD) and to investigate their relationships with disease activity.Hematological and inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), erythrocyte sedimentation rate (ESR), PLR, and LMR were examined in BD and healthy controls.Data from 140 patients with BD (108 with active and 32 with inactive disease) and 107 controls were enrolled. PLR (153.21 ± 65.44, 106.20 ± 28.91, P <.001, respectively) was remarkably higher, whereas LMR (5.37 ± 5.47, 8.95 ± 5.84, P <.001, respectively) was significantly lower in BD than in controls. Active BD patients had significantly higher PLR (159.20 vs 131.14, P = .037), ESR (38.30 vs 24.55, P = .017), and hs-CRP (30.20 vs 17.21, P = .027) than those with inactive BD. However, no significant difference in LMR was found between the groups. Moreover, PLR was positively correlated with BDCAF (r = 0.193, P <.05), hs-CRP (r = 0.402, P <.01), and ESR (r = 0.284, P <.01), whereas LMR was negatively correlated with BDCAF (r = -0.175, P <.05), hs-CPR (r = -0.263, P <.01), and ESR (r = -0.175, P <.05). Additionally, both PLR and LMR were shown to be independent factors for BD by multivariate logistic regression analysis. Furthermore, a PLR level of 124.63 was determined as the best cut-off value by ROC analysis (sensitivity 64.3%, specificity 78.0%, and the area under the ROC curve 0. 753).PLR was elevated in active BD as compared to inactive BD. PLR may be a reliable, cost-effective, and novel potential parameter to help evaluate disease activity in BD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28538403
OWN - NLM
STAT- MEDLINE
DA  - 20170524
DCOM- 20170629
LR  - 20170629
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 21
DP  - 2017 May
TI  - Serum PLR and LMR in Behcet's disease: Can they show the disease activity?
PG  - e6981
LID - 10.1097/MD.0000000000006981 [doi]
AB  - The aim of this study is to determine platelet to lymphocyte ratio (PLR) and
      lymphocytes to monocytes ratio (LMR) levels in Behcet's disease (BD) and to
      investigate their relationships with disease activity.Hematological and
      inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), 
      erythrocyte sedimentation rate (ESR), PLR, and LMR were examined in BD and
      healthy controls.Data from 140 patients with BD (108 with active and 32 with
      inactive disease) and 107 controls were enrolled. PLR (153.21 +/- 65.44, 106.20
      +/- 28.91, P &lt;.001, respectively) was remarkably higher, whereas LMR (5.37 +/-
      5.47, 8.95 +/- 5.84, P &lt;.001, respectively) was significantly lower in BD than in
      controls. Active BD patients had significantly higher PLR (159.20 vs 131.14, P = 
      .037), ESR (38.30 vs 24.55, P = .017), and hs-CRP (30.20 vs 17.21, P = .027) than
      those with inactive BD. However, no significant difference in LMR was found
      between the groups. Moreover, PLR was positively correlated with BDCAF (r =
      0.193, P &lt;.05), hs-CRP (r = 0.402, P &lt;.01), and ESR (r = 0.284, P &lt;.01), whereas 
      LMR was negatively correlated with BDCAF (r = -0.175, P &lt;.05), hs-CPR (r =
      -0.263, P &lt;.01), and ESR (r = -0.175, P &lt;.05). Additionally, both PLR and LMR
      were shown to be independent factors for BD by multivariate logistic regression
      analysis. Furthermore, a PLR level of 124.63 was determined as the best cut-off
      value by ROC analysis (sensitivity 64.3%, specificity 78.0%, and the area under
      the ROC curve 0. 753).PLR was elevated in active BD as compared to inactive BD.
      PLR may be a reliable, cost-effective, and novel potential parameter to help
      evaluate disease activity in BD.
FAU - Jiang, Ying
AU  - Jiang Y
AD  - aDepartment of Dermatology bDepartment of Surgery, First Hospital of Jilin
      University, Changchun, Jilin Province, China.
FAU - Zang, Mingcui
AU  - Zang M
FAU - Li, Shanshan
AU  - Li S
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*blood/*immunology
MH  - Biomarkers/blood
MH  - Blood Platelets/*immunology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Lymphocytes/*immunology
MH  - Male
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC5457883
EDAT- 2017/05/26 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/05/25 06:00
AID - 10.1097/MD.0000000000006981 [doi]
AID - 00005792-201705260-00044 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(21):e6981. doi: 10.1097/MD.0000000000006981.