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Unusual jaw metastasis from squamous cell lung cancer in heavy smoker: Two case reports and review of the literature.

Abstract Jaw metastasis is a very rare condition associated with lung cancer evolution. In this paper we present two cases of patients who underwent different approach.Lung cancer is the leading cause of cancer related death worldwide. Survival depends on the staging and biology of tumor. Smoking may affect the prognosis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28538407
OWN - NLM
STAT- In-Process
DA  - 20170524
LR  - 20170524
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 21
DP  - 2017 May
TI  - Unusual jaw metastasis from squamous cell lung cancer in heavy smoker: Two case
      reports and review of the literature.
PG  - e6987
LID - 10.1097/MD.0000000000006987 [doi]
AB  - RATIONALE: Jaw metastasis is a very rare condition associated with lung cancer
      evolution. In this paper we present two cases of patients who underwent different
      approach.Lung cancer is the leading cause of cancer related death worldwide.
      Survival depends on the staging and biology of tumor. Smoking may affect the
      prognosis. PATIENT CONCERNS: There are herein reported the cases of two patients 
      affected by squamous cell lung cancer with spread to mandibular bone. DIAGNOSES: 
      In the first case a computed tomography (CT scan) showed a large mass located in 
      upper right lung , then bronchoscopy was performed with biopsies and the
      histology revealed a squamous cell carcinoma P63+ and TTF-. In the second case
      upper right lung mass with metastases to mediastinal bilateral lymph nodes was
      found at CT scan. A bronchial biopsy revealed a squamous cell carcinoma p63
      positive and TTF-1 negative. INTERVENTIONS: The first, a 65-years old man,
      current heavy smoker who quit and relapsed, at initial stage of IIa (T2aN1M0),
      after initial neo-adjuvant chemotherapy underwent lung lobectomy and lymph nodes 
      resection. Three months later a metastasis located on mandibular bone was found
      out. The second case, a 68-years old female heavy smoker, at initial stage IIIb
      not available for surgery because of involvement of bilateral lymph nodes,
      underwent first line course chemotherapy with cisplatin and vinorelbine and
      second line with erlotinib. OUTCOMES: The first patient underwent hyperthermia
      and radiotherapy but a sepsis developed and patients died. In the second case,
      after two months from the beginning of II line the patient developed a jaw
      metastasis and underwent surgery with resection of hemi-mandible, but soon after 
      she died because of pulmonary embolism. LESSONS: These cases highlight the poor
      prognosis of patients current smokers affected by squamous cell lung cancer. The 
      jaw bone localization is very rare and different approach could be applied.
FAU - Pezzuto, Aldo
AU  - Pezzuto A
AD  - aDepartment of Cardiopulmonary and Vascular Science, Sant'Andrea
      Hospital-Sapienza University Rome, PhD Medical Bio-Science Campus bUnit of
      Physical and Rehabilitation Medicine, Department of Medicine, Campus Bio-Medico
      University cMaxillo-facial Unit, Surgery Department, S. Andrea Hospital-Sapienza 
      University, Rome, Italy.
FAU - Morrone, Michelangelo
AU  - Morrone M
FAU - Mici, Elidon
AU  - Mici E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/05/26 06:00
MHDA- 2017/05/26 06:00
CRDT- 2017/05/25 06:00
AID - 10.1097/MD.0000000000006987 [doi]
AID - 00005792-201705260-00048 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(21):e6987. doi: 10.1097/MD.0000000000006987.

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