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Lychee (Litchi chinensis Sonn.) pulp phenolic extract confers a protective activity against alcoholic liver disease in mice by alleviating mitochondrial dysfunction.

Abstract Mitochondria play an important role in the initiation and development of alcoholic liver disease (ALD). Our previous studies found lychee pulp phenolic extract (LPPE) exerted protective effect against ALD partly by inhibiting fatty acid β-oxidation, and phenolic-rich lychee pulp extract improved restraint stress-induced liver injury by inhibiting mitochondrial dysfunction. The aim of this study was to investigate whether LPPE exerted protective effect against ALD via modulating mitochondrial function, The mice were treated with an ethanol-containing liquid diet alone or in combination with LPPE for 8 weeks. LPPE supplementation significantly alleviated hepatic steatosis, suppressed serum aspartate aminotransferase activity, and decreased triglyceride levels in serum and liver. Based on lipid peroxidation and antioxidant enzyme analyses, LPPE supplementation inhibited serum and hepatic oxidative stress. Moreover, LPPE supplementation significantly suppressed mitochondrial 8-hydroxy-2'-deoxyguanosine level, and increased mitochondrial membrane potential, mitochondrial DNA content, activities of mitochondrial complexes I and IV, and hepatic ATP level. Furthermore, LPPE supplementation significantly inhibited cytoplasmic cytochrome c level and caspase-3 activity, repressed Bax expression and Bax/Bcl-2 ratio, and increased Bcl-2 expression in liver. In summary, LPPE exerts beneficial effects against alcoholic liver injury by alleviating mitochondrial dysfunction.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of agricultural and food chemistry
Publication Year Start




PMID- 28562048
OWN - NLM
STAT- Publisher
DA  - 20170531
LR  - 20170531
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
DP  - 2017 May 31
TI  - Lychee (Litchi chinensis Sonn.) pulp phenolic extract confers a protective
      activity against alcoholic liver disease in mice by alleviating mitochondrial
      dysfunction.
LID - 10.1021/acs.jafc.7b01844 [doi]
AB  - Mitochondria play an important role in the initiation and development of
      alcoholic liver disease (ALD). Our previous studies found lychee pulp phenolic
      extract (LPPE) exerted protective effect against ALD partly by inhibiting fatty
      acid beta-oxidation, and phenolic-rich lychee pulp extract improved restraint
      stress-induced liver injury by inhibiting mitochondrial dysfunction. The aim of
      this study was to investigate whether LPPE exerted protective effect against ALD 
      via modulating mitochondrial function, The mice were treated with an
      ethanol-containing liquid diet alone or in combination with LPPE for 8 weeks.
      LPPE supplementation significantly alleviated hepatic steatosis, suppressed serum
      aspartate aminotransferase activity, and decreased triglyceride levels in serum
      and liver. Based on lipid peroxidation and antioxidant enzyme analyses, LPPE
      supplementation inhibited serum and hepatic oxidative stress. Moreover, LPPE
      supplementation significantly suppressed mitochondrial
      8-hydroxy-2'-deoxyguanosine level, and increased mitochondrial membrane
      potential, mitochondrial DNA content, activities of mitochondrial complexes I and
      IV, and hepatic ATP level. Furthermore, LPPE supplementation significantly
      inhibited cytoplasmic cytochrome c level and caspase-3 activity, repressed Bax
      expression and Bax/Bcl-2 ratio, and increased Bcl-2 expression in liver. In
      summary, LPPE exerts beneficial effects against alcoholic liver injury by
      alleviating mitochondrial dysfunction.
FAU - Xiao, Juan
AU  - Xiao J
FAU - Zhang, Ruifen
AU  - Zhang R
FAU - Liu, Lei
AU  - Liu L
FAU - Huang, Fei
AU  - Huang F
FAU - Deng, Yuanyuan
AU  - Deng Y
FAU - Ma, Yongxuan
AU  - Ma Y
FAU - Wei, Zhencheng
AU  - Wei Z
FAU - Tang, Xiaojun
AU  - Tang X
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Zhang, Mingwei
AU  - Zhang M
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
EDAT- 2017/06/01 06:00
MHDA- 2017/06/01 06:00
CRDT- 2017/06/01 06:00
AID - 10.1021/acs.jafc.7b01844 [doi]
PST - aheadofprint
SO  - J Agric Food Chem. 2017 May 31. doi: 10.1021/acs.jafc.7b01844.

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