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Ophthalmoplegia associated with lung adenocarcinoma in a patient with the Lambert-Eaton myasthenic syndrome: A case report.

Abstract The Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular disease; its unique symptoms of LEMS include dry mouth with a metallic taste, constipation, and erectile dysfunction. As it is quite rare, isolated ocular muscle impairment associated with LEMS east to ignore.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28562525
OWN - NLM
STAT- MEDLINE
DA  - 20170531
DCOM- 20170626
LR  - 20170626
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 22
DP  - 2017 Jun
TI  - Ophthalmoplegia associated with lung adenocarcinoma in a patient with the
      Lambert-Eaton myasthenic syndrome: A case report.
PG  - e6484
LID - 10.1097/MD.0000000000006484 [doi]
AB  - RATIONALE: The Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular
      disease; its unique symptoms of LEMS include dry mouth with a metallic taste,
      constipation, and erectile dysfunction. As it is quite rare, isolated ocular
      muscle impairment associated with LEMS east to ignore. PATIENT CONCERNS: A
      65-year-old man presented with alternating ptosis and diplopia. Isolated ocular
      muscle impairment had lasted for 6 years, and the patient was initially diagnosed
      with ocular myasthenia gravis (MG). Treatment with azathioprine only slightly
      improved symptoms over the first 2 months; long-term treatment was not effective.
      DIAGNOSES: Dynamic observation of chest computed tomography images revealed a
      slowly progressing nodule in the lower lobe of the left lung. The subsequent
      pathologic examination following mass resection confirmed a diagnosis of lung
      adenocarcinoma. INTERVENTIONS: The patient was ultimately diagnosed with the
      Lambert-Eaton myasthenic syndrome associated with pulmonary adenocarcinoma.
      OUTCOMES: Resection of the lung tumor relieved all symptoms. LESSONS: Other
      causes of ocular MG symptoms should be considered when standard MG therapy is
      ineffective, especially the Lambert-Eaton myasthenic syndrome.
FAU - Tang, Yufeng
AU  - Tang Y
AD  - aDepartment of Neurology, West China Hospital, Sichuan University, Chengdu
      bDepartment of Neurology cDepartment of Ophthalmology, Mianyang Central Hospital,
      Mianyang, Sichuan dDepartment of Oncology, The Affiliated Jiangyin Hospital of
      Southeast University Medical College, Wuxi, Jiangsu, P.R. China.
FAU - Wang, Ke
AU  - Wang K
FAU - Chen, Zhonglun
AU  - Chen Z
FAU - Zhou, Muke
AU  - Zhou M
FAU - Duan, Jingfeng
AU  - Duan J
FAU - Liu, Tao
AU  - Liu T
FAU - Zhou, Dong
AU  - Zhou D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Adenocarcinoma of lung
SB  - AIM
SB  - IM
MH  - Adenocarcinoma/*complications/diagnostic imaging/pathology/surgery
MH  - Aged
MH  - Diagnosis, Differential
MH  - Humans
MH  - Lambert-Eaton Myasthenic Syndrome/*complications/diagnostic imaging/drug
      therapy/surgery
MH  - Lung Neoplasms/*complications/diagnostic imaging/pathology/surgery
MH  - Male
MH  - Ophthalmoplegia/diagnostic imaging/drug therapy/*etiology/surgery
PMC - PMC5459690
EDAT- 2017/06/01 06:00
MHDA- 2017/06/27 06:00
CRDT- 2017/06/01 06:00
AID - 10.1097/MD.0000000000006484 [doi]
AID - 00005792-201706020-00001 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(22):e6484. doi: 10.1097/MD.0000000000006484.