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Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis.

Abstract Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels in GCF and saliva of patients with or without CP.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28562542
OWN - NLM
STAT- MEDLINE
DA  - 20170531
DCOM- 20170626
LR  - 20170626
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 22
DP  - 2017 Jun
TI  - Association between interleukin-8 levels and chronic periodontal disease: A
      PRISMA-compliant systematic review and meta-analysis.
PG  - e6932
LID - 10.1097/MD.0000000000006932 [doi]
AB  - BACKGROUND: Current publications present contradictory findings regarding
      interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This
      systematic review compile evidences of the IL8 mRNA and protein levels in
      gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in
      patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels
      in GCF and saliva of patients with or without CP. METHODS: Electronic searches of
      the PubMed, Web of Science, and Scopus databases were conducted for publications 
      up to February 2016 that investigated the levels of IL-8 detected in individuals 
      with CP compared with health individuals. A total of 31 publications were
      included in the systematic review. For meta-analyses, the strength of association
      was calculated by pooled odds ratios with 95% confidence intervals using RevMan
      5.1 software. Heterogeneity was examined using Higgins I-squared, tau-squared,
      and chi tests. RESULTS: In biopsies of gingival tissue of CP patients, all
      studies found higher IL8 mRNA levels, and the majority of studies showed higher
      IL-8 protein levels in this tissue of individuals with moderate to severe CP.
      Four studies investigating the IL-8 levels in saliva showed inconclusive results.
      In spite of some studies seemed to indicate higher levels of IL-8 in GCF of CP
      patients, the meta-analysis results showed significantly lower IL-8 levels
      (pg/muL) in GCF of CP patients in comparison with periodontally healthy subjects.
      CONCLUSIONS: We concluded that IL8 gene expression and IL-8 protein levels were
      higher in gingival tissues of CP patients when compared to periodontally health
      individuals. Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found
      lower levels in CP patients. There are conflicting evidences regarding IL-8
      levels in saliva.
FAU - Finoti, Livia S
AU  - Finoti LS
AD  - aDepartment of Oral Diagnosis and Surgery, School of Dentistry at Araraquara, Sao
      Paulo State University (UNESP), Araraquara, SP, Brazil bDepartment of Medical
      Genetics, University of Campinas - UNICAMP, Campinas, SP, Brazil cDepartment of
      Morphology, School of Dentistry at Araraquara, Sao Paulo State University
      (UNESP), Araraquara, SP, Brazil dDepartment of Periodontics, School of Dental
      Medicine, University of Pennsylvania, Philadelphia, PA.
FAU - Nepomuceno, Rafael
AU  - Nepomuceno R
FAU - Pigossi, Suzane C
AU  - Pigossi SC
FAU - Corbi, Samia Ct
AU  - Corbi SC
FAU - Secolin, Rodrigo
AU  - Secolin R
FAU - Scarel-Caminaga, Raquel M
AU  - Scarel-Caminaga RM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (IL8 protein, human)
RN  - 0 (Interleukin-8)
SB  - AIM
SB  - IM
MH  - Biomarkers/metabolism
MH  - Chronic Periodontitis/*metabolism
MH  - Humans
MH  - Interleukin-8/*metabolism
PMC - PMC5459707
EDAT- 2017/06/01 06:00
MHDA- 2017/06/27 06:00
CRDT- 2017/06/01 06:00
AID - 10.1097/MD.0000000000006932 [doi]
AID - 00005792-201706020-00018 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(22):e6932. doi: 10.1097/MD.0000000000006932.

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