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Predictability and stability of laser-assisted subepithelial keratectomy with mitomycin C for the correction of high myopia.

Abstract The purpose of this study was to evaluate the predictability and stability of laser-assisted subepithelial keratectomy (LASEK) with mitomycin C (MMC) in correction of high myopia (≤-6.0 diopters [D]) as compared to low-to-moderate myopia (>-6.0 D).This is a retrospective, comparative, cohort study which included 43 eyes of 43 consecutive patients who underwent LASEK with MMC in a private hospital in Hong Kong by a single surgeon. Twenty-five eyes had high myopia (mean spherical equivalent [SE] = -8.53 ± 1.82 D) and 18 eyes had low-to-moderate myopia (mean SE = -3.99 ± 1.37 D) before surgery.In terms of refractive predictability, mean SE was significantly better in eyes with preoperative low-to-moderate myopia than high myopia at 6 months (0.04 ± 0.23 vs 0.31 ± 0.52 D, P = .035). In terms of refractive stability, between 1 and 3 months, both groups had mean absolute change of SE of around 0.25 D. Between 3 and 6 months, preoperative low-to-moderate myopia group had significantly less absolute change of SE compared to high myopia group (0.07 vs 0.23 D, P = .003). More eyes with preoperative high myopia changed SE by more than 0.25 D than those with low-to-moderate myopia between 3 and 6 months (32.0% vs 5.6%, P = .057).In conclusion, LASEK with MMC is more unpredictable and unstable in correction of high myopia than low-to-moderate myopia. The refractive outcome of most low-to-moderate myopia correction stabilizes at 3 months. Stability is not achieved until after 6 months in high myopia correction.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28562575
OWN - NLM
STAT- In-Process
DA  - 20170531
LR  - 20170531
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 22
DP  - 2017 Jun
TI  - Predictability and stability of laser-assisted subepithelial keratectomy with
      mitomycin C for the correction of high myopia.
PG  - e7076
LID - 10.1097/MD.0000000000007076 [doi]
AB  - The purpose of this study was to evaluate the predictability and stability of
      laser-assisted subepithelial keratectomy (LASEK) with mitomycin C (MMC) in
      correction of high myopia (</=-6.0 diopters [D]) as compared to low-to-moderate
      myopia (>-6.0 D).This is a retrospective, comparative, cohort study which
      included 43 eyes of 43 consecutive patients who underwent LASEK with MMC in a
      private hospital in Hong Kong by a single surgeon. Twenty-five eyes had high
      myopia (mean spherical equivalent [SE] = -8.53 +/- 1.82 D) and 18 eyes had
      low-to-moderate myopia (mean SE = -3.99 +/- 1.37 D) before surgery.In terms of
      refractive predictability, mean SE was significantly better in eyes with
      preoperative low-to-moderate myopia than high myopia at 6 months (0.04 +/- 0.23
      vs 0.31 +/- 0.52 D, P = .035). In terms of refractive stability, between 1 and 3 
      months, both groups had mean absolute change of SE of around 0.25 D. Between 3
      and 6 months, preoperative low-to-moderate myopia group had significantly less
      absolute change of SE compared to high myopia group (0.07 vs 0.23 D, P = .003).
      More eyes with preoperative high myopia changed SE by more than 0.25 D than those
      with low-to-moderate myopia between 3 and 6 months (32.0% vs 5.6%, P = .057).In
      conclusion, LASEK with MMC is more unpredictable and unstable in correction of
      high myopia than low-to-moderate myopia. The refractive outcome of most
      low-to-moderate myopia correction stabilizes at 3 months. Stability is not
      achieved until after 6 months in high myopia correction.
FAU - Iu, Lawrence P L
AU  - Iu LPL
AD  - aDepartment of Ophthalmology, The University of Hong Kong, Grantham Hospital
      bDepartment of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong.
FAU - Fan, Michelle C Y
AU  - Fan MCY
FAU - Chen, Ivan N
AU  - Chen IN
FAU - Lai, Jimmy S M
AU  - Lai JSM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/06/01 06:00
MHDA- 2017/06/01 06:00
CRDT- 2017/06/01 06:00
AID - 10.1097/MD.0000000000007076 [doi]
AID - 00005792-201706020-00051 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(22):e7076. doi: 10.1097/MD.0000000000007076.

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