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Differences in the Oxylipid Profiles of Bovine Milk and Plasma at Different Stages of Lactation.

Abstract Mastitis is caused by a bacterial infection of the mammary gland, which reduces both milk quality and quantity produced for human consumption. The incidence and severity of bovine mastitis are greatest during the periparturient period that results from dysfunctional inflammatory responses and causes damage to milk synthesizing tissues. Oxylipids are potent fatty acid-derived mediators that control the onset and resolution of the inflammatory response. The purpose of this study was to investigate how oxylipid profiles change in bovine milk at different stages of the lactation cycle. Results showed significantly lower concentrations of both milk polyunsaturated fatty acid content and total oxylipid biosynthesis during early lactation when compared to mid- or late-lactation. The only oxylipid that was higher during early lactation was 20-hydroxyeicosatetraenoic acid (HETE), which is often associated with inflammatory-based diseases. Milk oxylipid profiles during the different stages of lactation differed from plasma profiles. As such, plasma fatty acid and oxylipid concentrations are not a proxy for local changes in the mammary gland during the lactation cycle.
PMID
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Authors

Mayor MeshTerms
Keywords

bovine milk

eicosanoids

fatty acids

lipid mediators

mammary gland

oxylipids

oxylipins

Journal Title journal of agricultural and food chemistry
Publication Year Start




PMID- 28570057
OWN - NLM
STAT- MEDLINE
DA  - 20170601
DCOM- 20170703
LR  - 20170703
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 65
IP  - 24
DP  - 2017 Jun 21
TI  - Differences in the Oxylipid Profiles of Bovine Milk and Plasma at Different
      Stages of Lactation.
PG  - 4980-4988
LID - 10.1021/acs.jafc.7b01602 [doi]
AB  - Mastitis is caused by a bacterial infection of the mammary gland, which reduces
      both milk quality and quantity produced for human consumption. The incidence and 
      severity of bovine mastitis are greatest during the periparturient period that
      results from dysfunctional inflammatory responses and causes damage to milk
      synthesizing tissues. Oxylipids are potent fatty acid-derived mediators that
      control the onset and resolution of the inflammatory response. The purpose of
      this study was to investigate how oxylipid profiles change in bovine milk at
      different stages of the lactation cycle. Results showed significantly lower
      concentrations of both milk polyunsaturated fatty acid content and total oxylipid
      biosynthesis during early lactation when compared to mid- or late-lactation. The 
      only oxylipid that was higher during early lactation was
      20-hydroxyeicosatetraenoic acid (HETE), which is often associated with
      inflammatory-based diseases. Milk oxylipid profiles during the different stages
      of lactation differed from plasma profiles. As such, plasma fatty acid and
      oxylipid concentrations are not a proxy for local changes in the mammary gland
      during the lactation cycle.
FAU - Kuhn, Matthew J
AU  - Kuhn MJ
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine,
      Michigan State University , East Lansing 48824, United States.
FAU - Mavangira, Vengai
AU  - Mavangira V
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine,
      Michigan State University , East Lansing 48824, United States.
FAU - Gandy, Jeffery C
AU  - Gandy JC
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine,
      Michigan State University , East Lansing 48824, United States.
FAU - Zhang, Chen
AU  - Zhang C
FAU - Jones, A Daniel
AU  - Jones AD
FAU - Sordillo, Lorraine M
AU  - Sordillo LM
AUID- ORCID: http://orcid.org/0000-0001-8873-3134
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine,
      Michigan State University , East Lansing 48824, United States.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170613
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Fatty Acids)
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Cattle/*metabolism
MH  - Fatty Acids/chemistry/*metabolism
MH  - Female
MH  - Lactation
MH  - Lipids/chemistry
MH  - Mammary Glands, Animal/metabolism
MH  - Mastitis, Bovine/*metabolism/physiopathology
MH  - Milk/*chemistry/metabolism
OTO - NOTNLM
OT  - bovine milk
OT  - eicosanoids
OT  - fatty acids
OT  - lipid mediators
OT  - mammary gland
OT  - oxylipids
OT  - oxylipins
EDAT- 2017/06/02 06:00
MHDA- 2017/07/04 06:00
CRDT- 2017/06/02 06:00
AID - 10.1021/acs.jafc.7b01602 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2017 Jun 21;65(24):4980-4988. doi: 10.1021/acs.jafc.7b01602.
      Epub 2017 Jun 13.