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Synergistic protective effect of picrorhiza with honey in acetaminophen induced hepatic injury.

Abstract Rhizome of picrorhiza along with honey prevents hepatic damage and cure the acetaminophen (paracetamol) induced hepatotoxicity by modulating the activity of hepatic enzymes. Here, we studied the in vivo effects of Picrorhiza kurroa and honey on acetaminophen induced hepatotoxicity Balb/c mice model. Hepatic histopathological observations of acetaminophen fed (day-6) group showed more congestion, hemorrhage, necrosis, distorted hepatic architecture and nuclear inclusion. Such damages were recompensed to normal by picrorhiza or honey alone or both in combinations. We observed increased activity of SGPT and SGOT in injured liver tissues, and that too was compensated to normal with picrorhiza or honey alone or both in combinations. We observed 1.27 and 1.23-fold enhanced activity of SGPT in serum and liver lysate, respectively while SGOT showed 1.66 and 1.11 fold enhanced activity. These two enzymes are signature enzymes of liver damage. Thus, our results support that honey may be used with drug picrorhiza due to its synergistic role to enhance hepatoprotective and hepatoregenerative ability along with allopathic drugs to mitigate the hepatotoxic effects.
PMID
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Authors

Mayor MeshTerms

Acetaminophen

Honey

Keywords
Journal Title indian journal of experimental biology
Publication Year Start




PMID- 28577513
OWN - NLM
STAT- MEDLINE
DA  - 20170604
DCOM- 20170626
LR  - 20170626
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 54
IP  - 8
DP  - 2016 Aug
TI  - Synergistic protective effect of picrorhiza with honey in acetaminophen induced
      hepatic injury.
PG  - 530-6
AB  - Rhizome of picrorhiza along with honey prevents hepatic damage and cure the
      acetaminophen (paracetamol) induced hepatotoxicity by modulating the activity of 
      hepatic enzymes. Here, we studied the in vivo effects of Picrorhiza kurroa and
      honey on acetaminophen induced hepatotoxicity Balb/c mice model. Hepatic
      histopathological observations of acetaminophen fed (day-6) group showed more
      congestion, hemorrhage, necrosis, distorted hepatic architecture and nuclear
      inclusion. Such damages were recompensed to normal by picrorhiza or honey alone
      or both in combinations. We observed increased activity of SGPT and SGOT in
      injured liver tissues, and that too was compensated to normal with picrorhiza or 
      honey alone or both in combinations. We observed 1.27 and 1.23-fold enhanced
      activity of SGPT in serum and liver lysate, respectively while SGOT showed 1.66
      and 1.11 fold enhanced activity. These two enzymes are signature enzymes of liver
      damage. Thus, our results support that honey may be used with drug picrorhiza due
      to its synergistic role to enhance hepatoprotective and hepatoregenerative
      ability along with allopathic drugs to mitigate the hepatotoxic effects.
FAU - Gupta, Prashant
AU  - Gupta P
FAU - Tripathi, Alok
AU  - Tripathi A
FAU - Agrawal, Tripti
AU  - Agrawal T
FAU - Narayan, Chandradeo
AU  - Narayan C
FAU - Singh, B M
AU  - Singh BM
FAU - Kumar, Mohan
AU  - Kumar M
FAU - Kumar, Arvind
AU  - Kumar A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Biomarkers)
RN  - 0 (Plant Extracts)
RN  - 0 (Protective Agents)
RN  - 362O9ITL9D (Acetaminophen)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - *Acetaminophen
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Biomarkers/blood
MH  - Cell Survival/drug effects
MH  - Chemical and Drug Induced Liver Injury/blood/pathology/*prevention & control
MH  - Cytoprotection
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - *Honey
MH  - Liver/*drug effects/enzymology/pathology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Phytotherapy
MH  - Picrorhiza/*chemistry
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Plants, Medicinal
MH  - Protective Agents/isolation & purification/*pharmacology
MH  - Rhizome/chemistry
EDAT- 2017/06/05 06:00
MHDA- 2017/06/27 06:00
CRDT- 2017/06/05 06:00
PST - ppublish
SO  - Indian J Exp Biol. 2016 Aug;54(8):530-6.