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Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis.

Abstract Vitamin D serum levels and the presence and activity of rheumatic conditions have been associated. However, many studies are merely observational, and the existent randomized clinical trials were never systematically analyzed. Therefore, this study aims to provide a systematic review and meta-analysis of such a topic.
PMID
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Authors

Mayor MeshTerms

Dietary Supplements

Keywords
Journal Title medicine
Publication Year Start




PMID- 28591033
OWN - NLM
STAT- MEDLINE
DA  - 20170607
DCOM- 20170706
LR  - 20170706
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 23
DP  - 2017 Jun
TI  - Vitamin D supplementation and disease activity in patients with immune-mediated
      rheumatic diseases: A systematic review and meta-analysis.
PG  - e7024
LID - 10.1097/MD.0000000000007024 [doi]
AB  - BACKGROUND: Vitamin D serum levels and the presence and activity of rheumatic
      conditions have been associated. However, many studies are merely observational, 
      and the existent randomized clinical trials were never systematically analyzed.
      Therefore, this study aims to provide a systematic review and meta-analysis of
      such a topic. METHODS: MEDLINE, EMBASE, LILACS, COCHRANE, and CINAHL were
      explored to identify randomized trials that investigated clinical repercussions
      of vitamin D (or analogs) supplementation for at least 3 months in rheumatic
      diseases. Standardized clinical and/or laboratorial outcomes related to disease
      activity were analyzed according to each disease before and after
      supplementation. RESULTS: Database searches rendered 668 results; 9 were
      included-5 on rheumatoid arthritis, 3 on systemic lupus erythematosus, and 1 on
      systemic sclerosis. Seven of the studies were meta-analyzed. After vitamin D
      supplementation, rheumatoid arthritis recurrence decreased; however, not
      significantly (risk difference = -0.10, 95% CI = -0.21, 0.00, P = .05). No
      statistical significance was observed regarding visual analog scale (mean
      difference = 2.79, 95% CI = -1.87, 7.44, P = .24) and disease activity score28
      (mean difference = -0.31, 95% CI = -0.86, 0.25, P = .28). Regarding systemic
      lupus erythematosus, anti-dsDNA positivity was significantly reduced (risk
      difference = -0.10, 95% CI = -0.18, -0.03; P = .005). CONCLUSION: Vitamin D
      supplementation reduced anti-dsDNA positivity on systemic lupus erythematosus and
      could possibly reduce rheumatoid arthritis recurrence, although novel randomized 
      clinical trials are needed to confirm and extend the benefits of this hormone in 
      immune-mediated rheumatic diseases.
FAU - Franco, Andre Silva
AU  - Franco AS
AD  - aBone Metabolism Laboratory, Rheumatology Division, Hospital das Clinicas
      HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo bEvidence-based
      Guidelines Developing-Brazilian Medical Association-Sao Paulo, Sao Paulo, Brazil.
FAU - Freitas, Thiago Quadrante
AU  - Freitas TQ
FAU - Bernardo, Wanderley M
AU  - Bernardo WM
FAU - Pereira, Rosa Maria R
AU  - Pereira RMR
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 1406-16-2 (Vitamin D)
SB  - AIM
SB  - IM
MH  - *Dietary Supplements
MH  - Humans
MH  - Rheumatic Diseases/*diet therapy
MH  - Vitamin D/*administration & dosage
PMC - PMC5466211
EDAT- 2017/06/08 06:00
MHDA- 2017/07/07 06:00
CRDT- 2017/06/08 06:00
AID - 10.1097/MD.0000000000007024 [doi]
AID - 00005792-201706090-00009 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(23):e7024. doi: 10.1097/MD.0000000000007024.