PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Genetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease: A meta-analysis in Chinese pediatric population.

Abstract A meta-analysis of polymorphism C677T (rs1801133) of the methylene tetrahydrofolate reductase (MTHFR) gene as a potential risk factor for congenital heart disease (CHD) in Chinese paediatric population was studied in view of the previously reported controversial results.
PMID
Related Publications

Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.

Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies.

Association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke in the Chinese population: a meta-analysis.

Association between 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and congenital heart disease: A meta-analysis.

Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28591039
OWN - NLM
STAT- In-Process
DA  - 20170607
LR  - 20170607
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 23
DP  - 2017 Jun
TI  - Genetic polymorphism of methylenetetrahydrofolate reductase as a potential risk
      factor for congenital heart disease: A meta-analysis in Chinese pediatric
      population.
PG  - e7057
LID - 10.1097/MD.0000000000007057 [doi]
AB  - BACKGROUND: A meta-analysis of polymorphism C677T (rs1801133) of the methylene
      tetrahydrofolate reductase (MTHFR) gene as a potential risk factor for congenital
      heart disease (CHD) in Chinese paediatric population was studied in view of the
      previously reported controversial results. METHODS: We searched literature
      including PubMed, Embase, Cochrane Library, CNKI, Wanfang, and VIP databases that
      resulted in the identification of a total of 21 separate studies with 6414
      subjects that met the inclusion criteria in the Chinese population. The quality
      assessment of the included studies was preformed and relevant information was
      collected. We chose the fixed-effect model or random-effect model to calculate
      the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95%
      CI) where appropriate. Begg test was used to measure publication bias and
      sensitivity analyses were done to ensure authenticity of the outcome. RESULTS: We
      observed a significant association between MTHFR C677T polymorphism and CHD
      development in all the genetic models evaluated. The pooled ORs and 95% CIs in
      all genetic models indicated that children's MTHFR C677T polymorphism was
      significantly associated with CHD. CONCLUSION: Our study results indicate that
      MTHFR gene 677T polymorphism is a genetic risk factor in the development of CHD
      in Chinese paediatric population.
FAU - Yuan, Ye
AU  - Yuan Y
AD  - aDepartment of Anesthesiology bDepartment of Pediatrics, First Hospital, Jilin
      University cSchool of Public Health of Jilin University, Changchun, China.
FAU - Yu, Xia
AU  - Yu X
FAU - Niu, Fenglan
AU  - Niu F
FAU - Lu, Na
AU  - Lu N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:00
CRDT- 2017/06/08 06:00
AID - 10.1097/MD.0000000000007057 [doi]
AID - 00005792-201706090-00015 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(23):e7057. doi: 10.1097/MD.0000000000007057.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>