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Salivary protein polymorphisms and risk of dental caries: a systematic review.

Abstract Dental caries is an oral pathology associated with both lifestyle and genetic factors. The caries process can be influenced by salivary composition, which includes ions and proteins. Studies have described associations between salivary protein polymorphisms and dental caries experience, while others have shown no association with salivary proteins genetic variability. The aim of this study is to assess the influence of salivary protein polymorphisms on the risk of dental caries by means of a systematic review of the current literature. An electronic search was performed in PubMed, Scopus, and Virtual Health Library. The following search terms were used: "dental caries susceptibility," "dental caries," "polymorphism, genetics," "saliva," "proteins," and "peptides." Related MeSH headings and free terms were included. The inclusion criteria comprised clinical investigations of subjects with and without caries. After application of these eligibility criteria, the selected articles were qualified by assessing their methodological quality. Initially, 338 articles were identified from the electronic databases after exclusion of duplicates. Exclusion criteria eliminated 322 articles, and 16 remained for evaluation. Eleven articles found a consistent association between salivary protein polymorphisms and risk of dental caries, for proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion (lactotransferrin, mucin, and proline-rich protein Db). This systematic review demonstrated an association between genetic polymorphisms and risk of dental caries for most of the salivary proteins.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Genetic

Keywords
Journal Title brazilian oral research
Publication Year Start




PMID- 28591238
OWN - NLM
STAT- MEDLINE
DA  - 20170607
DCOM- 20170628
LR  - 20170628
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 31
DP  - 2017 Jun 05
TI  - Salivary protein polymorphisms and risk of dental caries: a systematic review.
PG  - e41
LID - S1806-83242017000100402 [pii]
LID - 10.1590/1807-3107BOR-2017.vol31.0041 [doi]
AB  - Dental caries is an oral pathology associated with both lifestyle and genetic
      factors. The caries process can be influenced by salivary composition, which
      includes ions and proteins. Studies have described associations between salivary 
      protein polymorphisms and dental caries experience, while others have shown no
      association with salivary proteins genetic variability. The aim of this study is 
      to assess the influence of salivary protein polymorphisms on the risk of dental
      caries by means of a systematic review of the current literature. An electronic
      search was performed in PubMed, Scopus, and Virtual Health Library. The following
      search terms were used: "dental caries susceptibility," "dental caries,"
      "polymorphism, genetics," "saliva," "proteins," and "peptides." Related MeSH
      headings and free terms were included. The inclusion criteria comprised clinical 
      investigations of subjects with and without caries. After application of these
      eligibility criteria, the selected articles were qualified by assessing their
      methodological quality. Initially, 338 articles were identified from the
      electronic databases after exclusion of duplicates. Exclusion criteria eliminated
      322 articles, and 16 remained for evaluation. Eleven articles found a consistent 
      association between salivary protein polymorphisms and risk of dental caries, for
      proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like
      protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion
      (lactotransferrin, mucin, and proline-rich protein Db). This systematic review
      demonstrated an association between genetic polymorphisms and risk of dental
      caries for most of the salivary proteins.
FAU - Lips, Andrea
AU  - Lips A
AD  - Universidade Federal Fluminense - UFF, Graduate Program in Sciences and
      Biotechnology, Niteroi, RJ, Brazil.
FAU - Antunes, Leonardo Santos
AU  - Antunes LS
AD  - Universidade Federal Fluminense - UFF, School of Dentistry, Department of
      Specific Formation, Nova Friburgo, RJ, Brazil.
FAU - Antunes, Livia Azeredo
AU  - Antunes LA
AD  - Universidade Federal Fluminense - UFF, School of Dentistry, Department of
      Specific Formation, Nova Friburgo, RJ, Brazil.
FAU - Pintor, Andrea Vaz Braga
AU  - Pintor AVB
AD  - Universidade Federal do Rio de Janeiro - UFRJ, School of Dentistry, Department of
      Pediatric Dentistry and Orthodontics, Rio de Janeiro, RJ, Brazil.
FAU - Santos, Diana Amado Baptista Dos
AU  - Santos DABD
AD  - Universidade Estadual do Rio de Janeiro - UERJ, Nursing and Dentistry Sectoral
      Library, Rio de Janeiro, RJ, Brazil.
FAU - Bachinski, Rober
AU  - Bachinski R
AD  - Universidade Federal Fluminense - UFF, Graduate Program in Sciences and
      Biotechnology, Niteroi, RJ, Brazil.
FAU - Kuchler, Erika Calvano
AU  - Kuchler EC
AD  - Universidade de Sao Paulo - USP-RP, Pediatric Dentistry Department, Ribeirao
      Preto, SP, Brazil.
FAU - Alves, Gutemberg Gomes
AU  - Alves GG
AD  - Universidade Federal Fluminense - UFF, Institute of Biology, Department of Cell
      and Molecular Biology, Niteroi, RJ, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170605
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (Genetic Markers)
RN  - 0 (Salivary Proteins and Peptides)
SB  - D
SB  - IM
MH  - DMF Index
MH  - Dental Caries/*genetics
MH  - Dental Caries Susceptibility/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Markers
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Salivary Proteins and Peptides/*genetics
EDAT- 2017/06/08 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/08 06:00
PHST- 2015/09/01 [received]
PHST- 2017/04/12 [accepted]
AID - S1806-83242017000100402 [pii]
AID - 10.1590/1807-3107BOR-2017.vol31.0041 [doi]
PST - epublish
SO  - Braz Oral Res. 2017 Jun 5;31:e41. doi: 10.1590/1807-3107BOR-2017.vol31.0041.