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Association between crack cocaine use and reduced salivary flow.

Abstract Crack cocaine use appears to have an impact on oral conditions. However, changes in the salivary flow among crack users have not been fully clarified. The aim of this study was to compare stimulated salivary flow and the occurrence of hyposalivation between crack users and non-users. A cross-sectional study was conducted involving 40 crack users and 40 controls matched for sex, age, and smoking habits. Interviews were conducted to acquire data on the perception of dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined using the spitting method. A significant reduction in stimulated salivary flow was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A total of 42.5% and 15% of crack users had very low and low stimulated salivary flow, respectively. Moreover, 65% of users reported xerostomia in comparison to 37.5% non-users (p < 0.012). No significant association was found between xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that individuals older than 26 years of age, those with a low household income, and crack users (prevalence ratio: 2.59) had a significant association with the occurrence of hyposalivation. A significant association was found between the use of crack and reduced salivary flow. The use of crack was associated with the occurrence of hyposalivation in the multivariate analysis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title brazilian oral research
Publication Year Start




PMID- 28591239
OWN - NLM
STAT- MEDLINE
DA  - 20170607
DCOM- 20170628
LR  - 20170628
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 31
DP  - 2017 Jun 05
TI  - Association between crack cocaine use and reduced salivary flow.
PG  - e42
LID - S1806-83242017000100240 [pii]
LID - 10.1590/1807-3107BOR-2017.vol31.0042 [doi]
AB  - Crack cocaine use appears to have an impact on oral conditions. However, changes 
      in the salivary flow among crack users have not been fully clarified. The aim of 
      this study was to compare stimulated salivary flow and the occurrence of
      hyposalivation between crack users and non-users. A cross-sectional study was
      conducted involving 40 crack users and 40 controls matched for sex, age, and
      smoking habits. Interviews were conducted to acquire data on the perception of
      dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined
      using the spitting method. A significant reduction in stimulated salivary flow
      was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A 
      total of 42.5% and 15% of crack users had very low and low stimulated salivary
      flow, respectively. Moreover, 65% of users reported xerostomia in comparison to
      37.5% non-users (p &lt; 0.012). No significant association was found between
      xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that 
      individuals older than 26 years of age, those with a low household income, and
      crack users (prevalence ratio: 2.59) had a significant association with the
      occurrence of hyposalivation. A significant association was found between the use
      of crack and reduced salivary flow. The use of crack was associated with the
      occurrence of hyposalivation in the multivariate analysis.
FAU - Antoniazzi, Raquel Pippi
AU  - Antoniazzi RP
AD  - Centro Universitario Franciscano, Santa Maria, RS, Brazil.
FAU - Sari, Amanda Rodrigues
AU  - Sari AR
AD  - Universidade Federal do Rio Grande do Sul - UFRGS, Faculty of Dentistry, Porto
      Alegre, Brazil.
FAU - Casarin, Maisa
AU  - Casarin M
AD  - Universidade Federal de Santa Maria - UFSM, Faculty of Dentistry, Santa Maria,
      RS, Brazil.
FAU - Moraes, Cristina Machado Braganca de
AU  - Moraes CMB
AD  - Centro Universitario Franciscano, Santa Maria, RS, Brazil.
FAU - Feldens, Carlos Alberto
AU  - Feldens CA
AD  - Universidade Luterana do Brasil, Postgraduate program in Dentistry, Canoas, RS,
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170605
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (Crack Cocaine)
SB  - D
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cocaine-Related Disorders/*physiopathology
MH  - Crack Cocaine/*adverse effects
MH  - Cross-Sectional Studies
MH  - DMF Index
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Salivation/*drug effects/physiology
MH  - Secretory Rate/drug effects
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Tobacco Use/adverse effects
MH  - Xerostomia/*chemically induced
MH  - Young Adult
EDAT- 2017/06/08 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/08 06:00
PHST- 2015/08/05 [received]
PHST- 2017/04/17 [accepted]
AID - S1806-83242017000100240 [pii]
AID - 10.1590/1807-3107BOR-2017.vol31.0042 [doi]
PST - epublish
SO  - Braz Oral Res. 2017 Jun 5;31:e42. doi: 10.1590/1807-3107BOR-2017.vol31.0042.