PubTransformer

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PMID- 28591390
OWN - NLM
STAT- MEDLINE
DA  - 20170607
DCOM- 20170630
LR  - 20170630
IS  - 1678-4227 (Electronic)
IS  - 0004-282X (Linking)
VI  - 75
IP  - 5
DP  - 2017 May
TI  - Long term follow-up of growth hormone-secreting pituitary adenomas submitted to
      endoscopic endonasal surgery.
PG  - 301-306
LID - S0004-282X2017000500301 [pii]
LID - 10.1590/0004-282X20170035 [doi]
AB  - Objective: The aim of this study was to evaluate the results of the endoscopic
      transsphenoidal technique for growth hormone (GH)-secreting adenomas. Methods: A 
      retrospective analysis based on medical records of 23 acromegalic patients
      submitted to endoscopic transsphenoidal surgery. Biochemical control was defined 
      as basal GH < 1ng/ml, nadir GH < 0.4ng/ml after glucose load and age-adjusted
      IGF-1 normal at the last follow-up. Results: The overall endocrinological
      remission rate was 39.1%. While all microademonas achieved a cure, just one third
      of macroadenomas went into remission. Suprasellar extension, cavernous sinus
      invasion and high GH levels were associated with lower rates of disease control. 
      The most common complication was diabetes insipidus and the most severe was an
      ischemic stroke. Conclusion: The endoscopic transsphenoidal approach is a safe
      and effective technique to control GH-secreting adenomas. The transcavernous
      approach may increase the risk of complications. Suprasellar and cavernous sinus 
      extensions may preclude gross total resection of these tumors.
FAU - Leopoldo, Caroline Martins Dos Santos
AU  - Leopoldo CMDS
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo SP, Brasil.
FAU - Leopoldo, Felippe Martins Dos Santos
AU  - Leopoldo FMDS
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo SP, Brasil.
FAU - Santos, Americo Rubens Leite Dos
AU  - Santos ARLD
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de Cirurgia,
      Disciplina de Neurocirurgia, Sao Paulo SP, Brasil.
FAU - Veiga, Jose Carlos Esteves
AU  - Veiga JCE
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de Cirurgia,
      Disciplina de Neurocirurgia, Sao Paulo SP, Brasil.
FAU - Lima, Jose Viana Junior
AU  - Lima JV Junior
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de Medicina,
      Disciplina de Endocrinologia, Sao Paulo SP, Brasil.
FAU - Scalissi, Nilza Maria
AU  - Scalissi NM
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de Medicina,
      Disciplina de Endocrinologia, Sao Paulo SP, Brasil.
FAU - Lazarini, Paulo Roberto
AU  - Lazarini PR
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de
      Otorrinolaringologia Sao Paulo SP, Brasil.
FAU - Dolci, Ricardo Landini Lutaif
AU  - Dolci RLL
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Departamento de
      Otorrinolaringologia Sao Paulo SP, Brasil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Neuropsiquiatr
JT  - Arquivos de neuro-psiquiatria
JID - 0125444
SB  - IM
MH  - Acromegaly/*surgery
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Growth Hormone-Secreting Pituitary Adenoma/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroendoscopy/adverse effects/*methods
MH  - Pituitary Neoplasms/*surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2017/06/08 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/06/08 06:00
PHST- 2016/09/16 [received]
PHST- 2017/01/24 [accepted]
AID - S0004-282X2017000500301 [pii]
AID - 10.1590/0004-282X20170035 [doi]
PST - ppublish
SO  - Arq Neuropsiquiatr. 2017 May;75(5):301-306. doi: 10.1590/0004-282X20170035.