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Accelerated versus conventional corneal crosslinking for refractive instability: an update.

Abstract Corneal crosslinking (CXL) is a relatively new treatment modality offering refractive stability in patients with ectatic disorders. The procedure as initially described (Dresden protocol) is time consuming; accelerated protocols have been lately developed. The purpose of this review is to present the recent findings regarding the comparison of accelerated CXL with the conventional Dresden protocol.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title current opinion in ophthalmology
Publication Year Start




PMID- 28594649
OWN - NLM
STAT- MEDLINE
DA  - 20170608
DCOM- 20170620
LR  - 20170620
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 28
IP  - 4
DP  - 2017 Jul
TI  - Accelerated versus conventional corneal crosslinking for refractive instability: 
      an update.
PG  - 343-347
LID - 10.1097/ICU.0000000000000375 [doi]
AB  - PURPOSE OF REVIEW: Corneal crosslinking (CXL) is a relatively new treatment
      modality offering refractive stability in patients with ectatic disorders. The
      procedure as initially described (Dresden protocol) is time consuming;
      accelerated protocols have been lately developed. The purpose of this review is
      to present the recent findings regarding the comparison of accelerated CXL with
      the conventional Dresden protocol. RECENT FINDINGS: A variety of accelerated
      protocols are described in the literature. Safety and efficacy of the procedures 
      with regard to stability seem to be equivalent in initial studies but indirect
      measures of efficacy, such as demarcation line depth and laboratory measurements,
      do not always confirm equivalence of accelerated protocols in comparison to
      conventional one. Modified accelerated protocols must be developed in order to
      overcome this. SUMMARY: Accelerated CXL protocols seem to be a valid alternative 
      to the conventional protocol; however, more comparative long term studies are
      needed to confirm the validity and to elucidate which accelerated protocol is
      ideal in each case.
FAU - Kymionis, George D
AU  - Kymionis GD
AD  - aJules Gonin Eye Hospital, Faculty of Biology and Medicine, University of
      Lausanne, Lausanne, SwitzerlandbDepartment of Ophthalmology, 'Gennimatas
      Hospital', National and Kapoditrian University of Athensc'Ophthalmiatreio' Eye
      Hospital of Athens, Athens, Greece.
FAU - Kontadakis, George A
AU  - Kontadakis GA
FAU - Hashemi, Kattayoon K
AU  - Hashemi KK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Photosensitizing Agents)
RN  - 9007-34-5 (Collagen)
RN  - TLM2976OFR (Riboflavin)
SB  - IM
MH  - Clinical Protocols
MH  - Clinical Studies as Topic
MH  - Collagen/metabolism
MH  - Corneal Stroma/metabolism
MH  - Cross-Linking Reagents/*therapeutic use
MH  - Humans
MH  - Keratoconus/*drug therapy/metabolism/pathology
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*therapeutic use
MH  - Riboflavin/therapeutic use
MH  - Tomography, Optical Coherence
MH  - Ultraviolet Rays
MH  - Visual Acuity
EDAT- 2017/06/09 06:00
MHDA- 2017/06/21 06:00
CRDT- 2017/06/09 06:00
AID - 10.1097/ICU.0000000000000375 [doi]
AID - 00055735-201707000-00009 [pii]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2017 Jul;28(4):343-347. doi: 10.1097/ICU.0000000000000375.

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