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Hospitalizations for Endocarditis and Associated Health Care Costs Among Persons with Diagnosed Drug Dependence - North Carolina, 2010-2015.

Abstract Opioid dependence and overdose have increased to epidemic levels in the United States. The 2014 National Survey on Drug Use and Health estimated that 4.3 million persons were nonmedical users of prescription pain relievers (1). These users are 40 times more likely than the general population to use heroin or other injection drugs (2). Furthermore, CDC estimated a near quadrupling of heroin-related overdose deaths during 2002-2014 (3). Although overdose contributes most to drug-associated mortality, infectious complications of intravenous drug use constitute a major cause of morbidity leading to hospitalization (4). In addition to infections from hepatitis C virus (HCV) and human immunodeficiency virus (HIV), injecting drug users are at increased risk for acquiring invasive bacterial infections, including endocarditis (5,6). Evidence that hospitalizations for endocarditis are increasing in association with the current opioid epidemic exists (7-9). To examine trends in hospitalizations for endocarditis among persons in North Carolina with drug dependence during 2010-2015, data from the North Carolina Hospital Discharge database were analyzed. The incidence of hospital discharge diagnoses for drug dependence combined with endocarditis increased more than twelvefold from 0.2 to 2.7 per 100,000 persons per year over this 6-year period. Correspondingly, hospital costs for these patients increased eighteenfold, from $1.1 million in 2010 to $22.2 million in 2015. To reduce the risk for morbidity and mortality related to opioid-associated endocarditis, public health programs and health care systems should consider collaborating to implement syringe service programs, harm reduction strategies, and opioid treatment programs.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title mmwr. morbidity and mortality weekly report
Publication Year Start




PMID- 28594786
OWN - NLM
STAT- MEDLINE
DA  - 20170608
DCOM- 20170609
LR  - 20170609
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Linking)
VI  - 66
IP  - 22
DP  - 2017 Jun 09
TI  - Hospitalizations for Endocarditis and Associated Health Care Costs Among Persons 
      with Diagnosed Drug Dependence - North Carolina, 2010-2015.
PG  - 569-573
LID - 10.15585/mmwr.mm6622a1 [doi]
AB  - Opioid dependence and overdose have increased to epidemic levels in the United
      States. The 2014 National Survey on Drug Use and Health estimated that 4.3
      million persons were nonmedical users of prescription pain relievers (1). These
      users are 40 times more likely than the general population to use heroin or other
      injection drugs (2). Furthermore, CDC estimated a near quadrupling of
      heroin-related overdose deaths during 2002-2014 (3). Although overdose
      contributes most to drug-associated mortality, infectious complications of
      intravenous drug use constitute a major cause of morbidity leading to
      hospitalization (4). In addition to infections from hepatitis C virus (HCV) and
      human immunodeficiency virus (HIV), injecting drug users are at increased risk
      for acquiring invasive bacterial infections, including endocarditis (5,6).
      Evidence that hospitalizations for endocarditis are increasing in association
      with the current opioid epidemic exists (7-9). To examine trends in
      hospitalizations for endocarditis among persons in North Carolina with drug
      dependence during 2010-2015, data from the North Carolina Hospital Discharge
      database were analyzed. The incidence of hospital discharge diagnoses for drug
      dependence combined with endocarditis increased more than twelvefold from 0.2 to 
      2.7 per 100,000 persons per year over this 6-year period. Correspondingly,
      hospital costs for these patients increased eighteenfold, from $1.1 million in
      2010 to $22.2 million in 2015. To reduce the risk for morbidity and mortality
      related to opioid-associated endocarditis, public health programs and health care
      systems should consider collaborating to implement syringe service programs, harm
      reduction strategies, and opioid treatment programs.
FAU - Fleischauer, Aaron T
AU  - Fleischauer AT
FAU - Ruhl, Laura
AU  - Ruhl L
FAU - Rhea, Sarah
AU  - Rhea S
FAU - Barnes, Erin
AU  - Barnes E
LA  - eng
PT  - Journal Article
DEP - 20170609
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Endocarditis/*therapy
MH  - Female
MH  - Health Care Costs/*statistics & numerical data
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - North Carolina
MH  - Substance-Related Disorders/*diagnosis/*economics
MH  - Young Adult
EDAT- 2017/06/09 06:00
MHDA- 2017/06/10 06:00
CRDT- 2017/06/09 06:00
AID - 10.15585/mmwr.mm6622a1 [doi]
PST - epublish
SO  - MMWR Morb Mortal Wkly Rep. 2017 Jun 9;66(22):569-573. doi:
      10.15585/mmwr.mm6622a1.

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