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Expression of inhibitory receptors and polyfunctional responses of T cells are linked to the risk of congenital transmission of T. cruzi.

Abstract Congenital T. cruzi infections involve multiple factors in which complex interactions between the parasite and the immune system of pregnant women play important roles. In this study, we used an experimental murine model of chronic infection with T. cruzi to evaluate the changes in the expression of inhibitory receptors and the polyfunctionality of T cells during gestation and their association with congenital transmission rate of T. cruzi infection. The results showed that pregnant naïve mice had a higher percentage of CD4+ and CD8+ T cells that expressed inhibitory receptors than cells from non-pregnant naïve mice. However, in mice chronically infected with T. cruzi, gestation induced a significant decrease in the frequency of T cells that expressed or co-expressed inhibitory receptors, as well as an increase in the frequency of polyfunctional CD4+ and CD8+ T cells. This different behavior may be due to the breakdown in the infected mice of the gestation-induced immune homeostasis, probably to control the parasite load. Remarkably, it was observed that the mothers that transmitted the parasite had a higher frequency of T cells that expressed and co-expressed inhibitory receptors as well as a lower frequency of polyfunctional parasite-specific T cells than those that did not transmit it, even though the parasitemia load was similar in both groups. All together these data suggest that the maternal immune profile of the CD4+ and CD8+ T cells could be a determining factor in the congenital transmission of T. cruzi.
PMID
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Authors

Mayor MeshTerms

Trypanosoma cruzi

Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28598971
OWN - NLM
STAT- MEDLINE
DA  - 20170609
DCOM- 20170714
LR  - 20170714
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 6
DP  - 2017 Jun
TI  - Expression of inhibitory receptors and polyfunctional responses of T cells are
      linked to the risk of congenital transmission of T. cruzi.
PG  - e0005627
LID - 10.1371/journal.pntd.0005627 [doi]
AB  - Congenital T. cruzi infections involve multiple factors in which complex
      interactions between the parasite and the immune system of pregnant women play
      important roles. In this study, we used an experimental murine model of chronic
      infection with T. cruzi to evaluate the changes in the expression of inhibitory
      receptors and the polyfunctionality of T cells during gestation and their
      association with congenital transmission rate of T. cruzi infection. The results 
      showed that pregnant naive mice had a higher percentage of CD4+ and CD8+ T cells 
      that expressed inhibitory receptors than cells from non-pregnant naive mice.
      However, in mice chronically infected with T. cruzi, gestation induced a
      significant decrease in the frequency of T cells that expressed or co-expressed
      inhibitory receptors, as well as an increase in the frequency of polyfunctional
      CD4+ and CD8+ T cells. This different behavior may be due to the breakdown in the
      infected mice of the gestation-induced immune homeostasis, probably to control
      the parasite load. Remarkably, it was observed that the mothers that transmitted 
      the parasite had a higher frequency of T cells that expressed and co-expressed
      inhibitory receptors as well as a lower frequency of polyfunctional
      parasite-specific T cells than those that did not transmit it, even though the
      parasitemia load was similar in both groups. All together these data suggest that
      the maternal immune profile of the CD4+ and CD8+ T cells could be a determining
      factor in the congenital transmission of T. cruzi.
FAU - Egui, Adriana
AU  - Egui A
AD  - Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de
      Investigaciones Cientificas (IPBLN-CSIC), Granada, Spain.
FAU - Lasso, Paola
AU  - Lasso P
AD  - Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de
      Investigaciones Cientificas (IPBLN-CSIC), Granada, Spain.
AD  - Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota,
      Colombia.
AD  - Grupo de Inmunobiologia y Biologia Celular, Facultad de Ciencias, Pontificia
      Universidad Javeriana, Bogota, Colombia.
FAU - Thomas, Maria Carmen
AU  - Thomas MC
AD  - Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de
      Investigaciones Cientificas (IPBLN-CSIC), Granada, Spain.
FAU - Carrilero, Bartolome
AU  - Carrilero B
AD  - Unidad Regional de Medicina Tropical, Hospital Virgen de la Arrixaca, Murcia,
      Spain.
FAU - Gonzalez, John Mario
AU  - Gonzalez JM
AD  - Grupo de Ciencias Basicas Medicas, Facultad de Medicina, Universidad de los
      Andes, Bogota, Colombia.
FAU - Cuellar, Adriana
AU  - Cuellar A
AD  - Grupo de Inmunobiologia y Biologia Celular, Facultad de Ciencias, Pontificia
      Universidad Javeriana, Bogota, Colombia.
FAU - Segovia, Manuel
AU  - Segovia M
AD  - Unidad Regional de Medicina Tropical, Hospital Virgen de la Arrixaca, Murcia,
      Spain.
FAU - Puerta, Concepcion Judith
AU  - Puerta CJ
AD  - Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota,
      Colombia.
FAU - Lopez, Manuel Carlos
AU  - Lopez MC
AUID- ORCID: http://orcid.org/0000-0003-0002-3678
AD  - Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de
      Investigaciones Cientificas (IPBLN-CSIC), Granada, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170609
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*physiology
MH  - CD8-Positive T-Lymphocytes/*physiology
MH  - Chagas Disease/*congenital/immunology/transmission
MH  - Cytokines/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation/*immunology/physiology
MH  - Infectious Disease Transmission, Vertical
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*immunology
MH  - *Trypanosoma cruzi
PMC - PMC5479596
EDAT- 2017/06/10 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/06/10 06:00
PHST- 2016/10/13 [received]
PHST- 2017/05/06 [accepted]
PHST- 2017/06/21 [revised]
AID - 10.1371/journal.pntd.0005627 [doi]
AID - PNTD-D-16-01871 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Jun 9;11(6):e0005627. doi: 10.1371/journal.pntd.0005627.
      eCollection 2017 Jun.