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Mycoplasma hyopneumoniae vaccination at or shortly before weaning under field conditions: a randomised efficacy trial.

Abstract This study assessed the efficacy of two different Mycoplasma hyopneumoniae vaccination programmes in relation to the time of weaning. Eight hundred and twenty-eight piglets were randomly divided into three groups: group V1 was vaccinated three days before weaning, group V2 at weaning (21 days of age) and group NV was left non-vaccinated. Vaccinations were performed using Ingelvac MycoFLEX. After the nursery period, 306 pigs were allocated to fattening unit (F1) and 501 pigs to a second unit (F2). Efficacy was evaluated using performance parameters and pneumonia lesions at slaughter. Statistically significant differences were obtained in F2 where group V1 had a higher average daily weight gain compared to groups V2 and NV for the entire study period (17 and 18 g/day, respectively) and the fattening period (26 and 36 g/day, respectively) (P<0.05). Considering respiratory disease scores for both fattening units, group V1 was the only group where coughing severity did not increase significantly between placement and the end of the fattening period (P>0.05). Between groups, there were no statistically significant differences for the average lung lesion scores (V1=3.44; V2=4.61; NV=4.55, P>0.05) and the prevalence of pneumonia (V1=35.0 per cent; V2=38.0 per cent; NV=41.4 per cent, P>0.05). Overall, vaccination against M hyopneumoniae before weaning provided numerically better performance than vaccination at weaning, but did not reach statistical significance. An influenza outbreak in F1 and the presence of coexisting mixed respiratory infections in both F1 and F2 could have possibly influenced the performance of both vaccinated groups across all measured parameters.
PMID
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Authors

Mayor MeshTerms

Weaning

Keywords

<i>Mycoplasma hyopneumoniae</i>

Efficacy

Field study

Vaccination

Weaning

Journal Title the veterinary record
Publication Year Start




PMID- 28601840
OWN - NLM
STAT- MEDLINE
DA  - 20170611
DCOM- 20170707
LR  - 20170707
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 181
IP  - 1
DP  - 2017 Jul 01
TI  - Mycoplasma hyopneumoniae vaccination at or shortly before weaning under field
      conditions: a randomised efficacy trial.
PG  - 19
LID - 10.1136/vr.104075 [doi]
AB  - This study assessed the efficacy of two different Mycoplasma hyopneumoniae
      vaccination programmes in relation to the time of weaning. Eight hundred and
      twenty-eight piglets were randomly divided into three groups: group V1 was
      vaccinated three days before weaning, group V2 at weaning (21 days of age) and
      group NV was left non-vaccinated. Vaccinations were performed using Ingelvac
      MycoFLEX. After the nursery period, 306 pigs were allocated to fattening unit
      (F1) and 501 pigs to a second unit (F2). Efficacy was evaluated using performance
      parameters and pneumonia lesions at slaughter. Statistically significant
      differences were obtained in F2 where group V1 had a higher average daily weight 
      gain compared to groups V2 and NV for the entire study period (17 and 18 g/day,
      respectively) and the fattening period (26 and 36 g/day, respectively) (P&lt;0.05). 
      Considering respiratory disease scores for both fattening units, group V1 was the
      only group where coughing severity did not increase significantly between
      placement and the end of the fattening period (P&gt;0.05). Between groups, there
      were no statistically significant differences for the average lung lesion scores 
      (V1=3.44; V2=4.61; NV=4.55, P&gt;0.05) and the prevalence of pneumonia (V1=35.0 per 
      cent; V2=38.0 per cent; NV=41.4 per cent, P&gt;0.05). Overall, vaccination against M
      hyopneumoniae before weaning provided numerically better performance than
      vaccination at weaning, but did not reach statistical significance. An influenza 
      outbreak in F1 and the presence of coexisting mixed respiratory infections in
      both F1 and F2 could have possibly influenced the performance of both vaccinated 
      groups across all measured parameters.
CI  - British Veterinary Association.
FAU - Arsenakis, I
AU  - Arsenakis I
AD  - Unit Porcine Health Management, Department of Reproduction, Obstetrics &amp; Herd
      Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133,
      Merelbeke 9820, Belgium.
FAU - Michiels, A
AU  - Michiels A
AD  - Unit Porcine Health Management, Department of Reproduction, Obstetrics &amp; Herd
      Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133,
      Merelbeke 9820, Belgium.
FAU - Del Pozo Sacristan, R
AU  - Del Pozo Sacristan R
AD  - Unit Porcine Health Management, Department of Reproduction, Obstetrics &amp; Herd
      Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133,
      Merelbeke 9820, Belgium.
FAU - Boyen, F
AU  - Boyen F
AD  - Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary
      Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium.
FAU - Haesebrouck, F
AU  - Haesebrouck F
AD  - Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary
      Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium.
FAU - Maes, D
AU  - Maes D
AD  - Unit Porcine Health Management, Department of Reproduction, Obstetrics &amp; Herd
      Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133,
      Merelbeke 9820, Belgium.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170610
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Bacterial Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Vaccines/*administration &amp; dosage
MH  - Immunization Schedule
MH  - Pneumonia of Swine, Mycoplasmal/*prevention &amp; control
MH  - Swine
MH  - Treatment Outcome
MH  - Vaccination/methods/*veterinary
MH  - *Weaning
OTO - NOTNLM
OT  - &lt;i&gt;Mycoplasma hyopneumoniae&lt;/i&gt;
OT  - Efficacy
OT  - Field study
OT  - Vaccination
OT  - Weaning
EDAT- 2017/06/12 06:00
MHDA- 2017/07/08 06:00
CRDT- 2017/06/12 06:00
PHST- 2017/04/23 [accepted]
AID - vr.104075 [pii]
AID - 10.1136/vr.104075 [doi]
PST - ppublish
SO  - Vet Rec. 2017 Jul 1;181(1):19. doi: 10.1136/vr.104075. Epub 2017 Jun 10.