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Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study.

Abstract Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28604825
OWN - NLM
STAT- In-Process
DA  - 20170612
LR  - 20170622
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 6
DP  - 2017 Jun
TI  - Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective
      observational study.
PG  - e0005606
LID - 10.1371/journal.pntd.0005606 [doi]
AB  - BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium
      vivax infection annually, little is known about the epidemiology and impact of
      the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a
      health facility-based prospective observational study in pregnant women from
      Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG).
      Malaria and anemia were determined during pregnancy and fetal outcomes assessed
      at delivery. A total of 9388 women were enrolled at antennal care (ANC), of whom 
      53% (4957) were followed until delivery. Prevalence of P. vivax monoinfection in 
      maternal blood at delivery was 0.4% (20/4461) by microscopy [GT 0.1%, CO 0.5%, BR
      0.1%, IN 0.2%, PNG 1.2%] and 7% (104/1488) by PCR. P. falciparum monoinfection
      was found in 0.5% (22/4463) of women by microscopy [GT 0%, CO 0.5%, BR 0%, IN 0%,
      PNG 2%]. P. vivax infection was observed in 0.4% (14/3725) of placentas examined 
      by microscopy and in 3.7% (19/508) by PCR. P. vivax in newborn blood was detected
      in 0.02% (1/4302) of samples examined by microscopy [in cord blood; 0.05%
      (2/4040) by microscopy, and 2.6% (13/497) by PCR]. Clinical P. vivax infection
      was associated with increased risk of maternal anemia (Odds Ratio-OR, 5.48, [95% 
      CI 1.83-16.41]; p = 0.009), while submicroscopic vivax infection was not
      associated with increased risk of moderate-severe anemia (Hb<8g/dL) (OR, 1.16,
      [95% CI 0.52-2.59]; p = 0.717), or low birth weight (<2500g) (OR, 0.52, [95% CI, 
      0.23-1.16]; p = 0.110). CONCLUSIONS: In this multicenter study, the prevalence of
      P. vivax infection in pregnancy by microscopy was overall low across all endemic 
      study sites; however, molecular methods revealed a significant number of
      submicroscopic infections. Clinical vivax infection in pregnancy was associated
      with maternal anemia, which may be deleterious for infant's health. These results
      may help to guide maternal health programs in settings where vivax malaria is
      endemic; they also highlight the need of addressing a vulnerable population such 
      as pregnant women while embracing malaria elimination in endemic countries.
FAU - Bardaji, Azucena
AU  - Bardaji A
AUID- ORCID: http://orcid.org/0000-0002-5135-0540
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Martinez-Espinosa, Flor Ernestina
AU  - Martinez-Espinosa FE
AD  - Gerencia de Malaria, Fundacao de Medicina Tropical Dr. Heitor Vieira Dourado,
      Manaus, Brazil.
AD  - Instituto Leonidas e Maria Deane, FIOCRUZ Amazonia, Manaus, Brazil.
FAU - Arevalo-Herrera, Myriam
AU  - Arevalo-Herrera M
AD  - Caucaseco Scientific Research Center/Universidad del Valle, Cali, Colombia.
FAU - Padilla, Norma
AU  - Padilla N
AD  - Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala,
      Guatemala.
FAU - Kochar, Swati
AU  - Kochar S
AD  - Department of Medicine, Sardar Patel Medical College, Bikaner, Rajasthan, India.
FAU - Ome-Kaius, Maria
AU  - Ome-Kaius M
AD  - Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua
      New Guinea.
FAU - Botto-Menezes, Camila
AU  - Botto-Menezes C
AD  - Gerencia de Malaria, Fundacao de Medicina Tropical Dr. Heitor Vieira Dourado,
      Manaus, Brazil.
FAU - Castellanos, Maria Eugenia
AU  - Castellanos ME
AD  - Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala,
      Guatemala.
FAU - Kochar, Dhanpat Kumar
AU  - Kochar DK
AD  - Department of Medicine, Sardar Patel Medical College, Bikaner, Rajasthan, India.
FAU - Kochar, Sanjay Kumar
AU  - Kochar SK
AD  - Department of Medicine, Sardar Patel Medical College, Bikaner, Rajasthan, India.
FAU - Betuela, Inoni
AU  - Betuela I
AD  - Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua
      New Guinea.
FAU - Mueller, Ivo
AU  - Mueller I
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
AD  - The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
FAU - Rogerson, Stephen
AU  - Rogerson S
AD  - Department of Medicine (Royal Melbourne Hospital), The University of Melbourne,
      Parkville, Victoria, Australia.
FAU - Chitnis, Chetan
AU  - Chitnis C
AD  - International Center for Genetic Engineering and Biotechnology, New Delhi, India.
FAU - Hans, Dhiraj
AU  - Hans D
AD  - International Center for Genetic Engineering and Biotechnology, New Delhi, India.
FAU - Menegon, Michela
AU  - Menegon M
AD  - Department of Infectious, Parasitic and Immunomediated Diseases, Istituto
      Superiore di Sanita, Rome, Italy.
FAU - Severini, Carlo
AU  - Severini C
AD  - Department of Infectious, Parasitic and Immunomediated Diseases, Istituto
      Superiore di Sanita, Rome, Italy.
FAU - Del Portillo, Hernando
AU  - Del Portillo H
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
AD  - Institucio Catalana de Recerca i Estudis Avancats, Barcelona, Spain.
FAU - Dobano, Carlota
AU  - Dobano C
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Mayor, Alfredo
AU  - Mayor A
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Ordi, Jaume
AU  - Ordi J
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Piqueras, Mireia
AU  - Piqueras M
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Sanz, Sergi
AU  - Sanz S
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
FAU - Wahlgren, Mats
AU  - Wahlgren M
AD  - Karolinska Institute, Stockholm, Sweden.
FAU - Slutsker, Laurence
AU  - Slutsker L
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global
      Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United
      States of America.
FAU - Desai, Meghna
AU  - Desai M
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global
      Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United
      States of America.
FAU - Menendez, Clara
AU  - Menendez C
AD  - Barcelona Center for International Health Research, CRESIB, ISGlobal, Hospital
      Clinic - Universitat de Barcelona, Barcelona, Spain.
CN  - PregVax Study Group
LA  - eng
PT  - Journal Article
DEP - 20170612
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/06/13 06:00
MHDA- 2017/06/13 06:00
CRDT- 2017/06/13 06:00
PHST- 2016/11/24 [received]
PHST- 2017/04/27 [accepted]
PHST- 2017/06/22 [revised]
AID - 10.1371/journal.pntd.0005606 [doi]
AID - PNTD-D-16-02128 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Jun 12;11(6):e0005606. doi:
      10.1371/journal.pntd.0005606. eCollection 2017 Jun.