PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients with membranous nephropathy: A cross-sectional study.

Abstract M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and their association with clinical characteristics need to be further evaluated.A total of 136 patients were involved as inception group because serum anti-PLA2R antibody and glomerular PLA2R antigen were simultaneously measured. We examined serum anti-PLA2R antibody by ELISA and glomerular PLA2R deposition by immunofluorescence assay.Positive serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8% (80/136) and 95.6% (130/136) patients, respectively (Pā€Š<ā€Š.001). Proteinuria, serum total protein, serum albumin, serum creatinine, and estimated glomerular filtration rate (eGFR) had significant differences between patients with serum anti-PLA2R antibody and those without. Serum anti-PLA2R antibody levels were correlated with serum albumin, serum creatinine, eGFR, and proteinuria. Glomerular PLA2R deposition intensities were weakly correlated with proteinuria. Unexpectedly, there was a positive correlation rather than a negative correlation between glomerular PLA2R deposition intensity and eGFR.In conclusion, serum anti-PLA2R antibody is more closely correlated with disease activity and renal function than glomerular PLA2R deposition.
PMID
Related Publications

Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN).

Prevalence, diagnostic value and clinical characteristics associated with the presence of circulating levels and renal deposits of antibodies against the M-type phospholipase A2 receptor in idiopathic membranous nephropathy.

Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy in Japanese.

The relationship between anti-phospholipase A2 receptor antibody and idiopathic membranous nephropathy.

Anti-PLA2R Antibodies in Chinese Patients with Membranous Nephropathy.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28614271
OWN - NLM
STAT- MEDLINE
DA  - 20170614
DCOM- 20170706
LR  - 20170706
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 24
DP  - 2017 Jun
TI  - Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients
      with membranous nephropathy: A cross-sectional study.
PG  - e7218
LID - 10.1097/MD.0000000000007218 [doi]
AB  - M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary
      membranous nephropathy (PMN). Previous studies have evaluated the diagnostic
      value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R 
      antibody and glomerular PLA2R deposition, and their association with clinical
      characteristics need to be further evaluated.A total of 136 patients were
      involved as inception group because serum anti-PLA2R antibody and glomerular
      PLA2R antigen were simultaneously measured. We examined serum anti-PLA2R antibody
      by ELISA and glomerular PLA2R deposition by immunofluorescence assay.Positive
      serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8%
      (80/136) and 95.6% (130/136) patients, respectively (P &lt; .001). Proteinuria,
      serum total protein, serum albumin, serum creatinine, and estimated glomerular
      filtration rate (eGFR) had significant differences between patients with serum
      anti-PLA2R antibody and those without. Serum anti-PLA2R antibody levels were
      correlated with serum albumin, serum creatinine, eGFR, and proteinuria.
      Glomerular PLA2R deposition intensities were weakly correlated with proteinuria. 
      Unexpectedly, there was a positive correlation rather than a negative correlation
      between glomerular PLA2R deposition intensity and eGFR.In conclusion, serum
      anti-PLA2R antibody is more closely correlated with disease activity and renal
      function than glomerular PLA2R deposition.
FAU - Pang, Lu
AU  - Pang L
AD  - aDepartment of Clinical Laboratory, Peking University First Hospital, Beijing
      bDepartment of Clinical Laboratory, Tianjin Nankai Hospital, Tianjin, The
      People's Republic of China.
FAU - Zhang, Ai-Min
AU  - Zhang AM
FAU - Li, Hai-Xia
AU  - Li HX
FAU - Du, Jia-Lin
AU  - Du JL
FAU - Jiao, Li-Li
AU  - Jiao LL
FAU - Duan, Nan
AU  - Duan N
FAU - Liu, Yi
AU  - Liu Y
FAU - Yu, Dan
AU  - Yu D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (PLA2R1 protein, human)
RN  - 0 (Receptors, Phospholipase A2)
RN  - 0 (Serum Albumin)
RN  - AYI8EX34EU (Creatinine)
SB  - AIM
SB  - IM
MH  - Autoantibodies/*blood
MH  - Biomarkers/metabolism
MH  - China
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fluorescent Antibody Technique
MH  - Glomerular Filtration Rate
MH  - Glomerulonephritis, Membranous/drug therapy/*metabolism/pathology
MH  - Humans
MH  - Immunoglobulin G/*metabolism
MH  - Kidney/*metabolism/pathology
MH  - Proteinuria/drug therapy/metabolism/pathology
MH  - Receptors, Phospholipase A2/*metabolism
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Serum Albumin/analysis
EDAT- 2017/06/15 06:00
MHDA- 2017/07/07 06:00
CRDT- 2017/06/15 06:00
AID - 10.1097/MD.0000000000007218 [doi]
AID - 00005792-201706160-00057 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(24):e7218. doi: 10.1097/MD.0000000000007218.