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Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia.

Abstract Few studies have addressed Leptospira seroprevalence and risk factors in urban populations in Colombia. This study aimed to determine seroprevalence and factors associated with Leptospira infection in inhabitants of an urban district of Cali, Colombia. We collected sociodemographic and environmental data, as well as blood samples, from 353 subjects selected through a multistage cluster sampling design. We performed microagglutination test for the eight main Leptospira serogroups circulating in the region, considering a cut-off titer of ≥ 1:100. Most participants were female (226, 64.8%), with mean age 41.4 years, and 89 (32.6%) lived in low-low socioeconomic stratum (SES-1). Overall seroprevalence was 12.2% (95%CI: 10.3%-14.4%). Factors associated with Leptospira infection were SES 1, older age, single marital status, ethnic groups (Afro-Colombian and white/mestizo), school students, absence of toilet, barefoot walking, travel outside Cali in the previous month, and absence of skin and mucous-membrane lesions in the previous month. Our study suggests domestic and peridomiciliary transmission of Leptospira likely related to activities of daily living and inadequate environmental conditions. SES-1 is a major factor associated with Leptospira infection (adjusted OR = 4.08; 95%CI: 2.54-6.53; p < 0.001), suggesting that social and environmental conditions are key elements for endemicity of Leptospira infection in the study area. Epidemiological surveillance, improvement of environmental and sanitary conditions in various SES-1 areas, and community educational campaigns are recommended.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title cadernos de saude publica
Publication Year Start




PMID- 28614448
OWN - NLM
STAT- MEDLINE
DA  - 20170614
DCOM- 20170705
LR  - 20170705
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 33
IP  - 5
DP  - 2017 Jun 12
TI  - Seroprevalence and factors associated with Leptospira infection in an urban
      district of Cali, Colombia.
PG  - e00039216
LID - S0102-311X2017000505004 [pii]
LID - 10.1590/0102-311X00039216 [doi]
AB  - Few studies have addressed Leptospira seroprevalence and risk factors in urban
      populations in Colombia. This study aimed to determine seroprevalence and factors
      associated with Leptospira infection in inhabitants of an urban district of Cali,
      Colombia. We collected sociodemographic and environmental data, as well as blood 
      samples, from 353 subjects selected through a multistage cluster sampling design.
      We performed microagglutination test for the eight main Leptospira serogroups
      circulating in the region, considering a cut-off titer of &gt;/= 1:100. Most
      participants were female (226, 64.8%), with mean age 41.4 years, and 89 (32.6%)
      lived in low-low socioeconomic stratum (SES-1). Overall seroprevalence was 12.2% 
      (95%CI: 10.3%-14.4%). Factors associated with Leptospira infection were SES 1,
      older age, single marital status, ethnic groups (Afro-Colombian and
      white/mestizo), school students, absence of toilet, barefoot walking, travel
      outside Cali in the previous month, and absence of skin and mucous-membrane
      lesions in the previous month. Our study suggests domestic and peridomiciliary
      transmission of Leptospira likely related to activities of daily living and
      inadequate environmental conditions. SES-1 is a major factor associated with
      Leptospira infection (adjusted OR = 4.08; 95%CI: 2.54-6.53; p &lt; 0.001),
      suggesting that social and environmental conditions are key elements for
      endemicity of Leptospira infection in the study area. Epidemiological
      surveillance, improvement of environmental and sanitary conditions in various
      SES-1 areas, and community educational campaigns are recommended.
FAU - Escandon-Vargas, Kevin
AU  - Escandon-Vargas K
AD  - Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia.
AD  - Escuela de Ciencias Basicas, Facultad de Salud, Universidad del Valle, Cali,
      Colombia.
FAU - Osorio, Lyda
AU  - Osorio L
AD  - Escuela de Salud Publica, Facultad de Salud, Universidad del Valle, Cali,
      Colombia.
FAU - Astudillo-Hernandez, Miryam
AU  - Astudillo-Hernandez M
AD  - Escuela de Ciencias Basicas, Facultad de Salud, Universidad del Valle, Cali,
      Colombia.
LA  - eng
PT  - Journal Article
DEP - 20170612
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
SB  - IM
MH  - Adult
MH  - Colombia/epidemiology
MH  - Communicable Diseases
MH  - Female
MH  - Humans
MH  - Leptospira
MH  - Leptospirosis/blood/*epidemiology/*transmission
MH  - Male
MH  - Residence Characteristics
MH  - Risk Factors
MH  - Seroepidemiologic Studies
MH  - Socioeconomic Factors
MH  - Urban Population/statistics &amp; numerical data
EDAT- 2017/06/15 06:00
MHDA- 2017/07/06 06:00
CRDT- 2017/06/15 06:00
PHST- 2016/03/09 [received]
PHST- 2016/07/13 [accepted]
AID - S0102-311X2017000505004 [pii]
AID - 10.1590/0102-311X00039216 [doi]
PST - epublish
SO  - Cad Saude Publica. 2017 Jun 12;33(5):e00039216. doi: 10.1590/0102-311X00039216.