PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell lymphomas: The key role of exosomes.

Abstract B-cell lymphomas are composed of tumor cells and the tumor microenvironment, which is conventionally thought to be composed of a mixture of stromal cells, blood vessels, immune cells, and non-cell components, such as extracellular matrix, cytokines, and chemokines. Exosomes, small endocytically derived vesicles that have been proved to be present in a variety of tumor niches and involved in mediating cell signaling networks, are increasingly regarded as important components of tumor microenvironment. In this review, we first focus on the biogenesis, biodistribution, transportation, and other general characteristics of exosomes and then highlight the vital roles of exosomes in lymphomagenesis and disease progression, particularly from the perspective of immune dysfunction, virus infection, and therapeutic resistance mechanisms.
PMID
Related Publications

The host-tumor interface in B-cell non-Hodgkin lymphoma: a new world to investigate.

Tumor-Derived Exosomes and Their Role in Cancer Progression.

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments.

The challenge of the microenvironment in B-cell lymphomas.

Shaping of the tumor microenvironment: Stromal cells and vessels.

Authors

Mayor MeshTerms

Immunity, Cellular

Keywords

B-cell lymphomas

Microenvironment

drug resistance

exosomes

immunotherapy

lymphomagenesis

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28618932
OWN - NLM
STAT- MEDLINE
DA  - 20170616
DCOM- 20170622
LR  - 20170622
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell
      lymphomas: The key role of exosomes.
PG  - 1010428317706227
LID - 10.1177/1010428317706227 [doi]
AB  - B-cell lymphomas are composed of tumor cells and the tumor microenvironment,
      which is conventionally thought to be composed of a mixture of stromal cells,
      blood vessels, immune cells, and non-cell components, such as extracellular
      matrix, cytokines, and chemokines. Exosomes, small endocytically derived vesicles
      that have been proved to be present in a variety of tumor niches and involved in 
      mediating cell signaling networks, are increasingly regarded as important
      components of tumor microenvironment. In this review, we first focus on the
      biogenesis, biodistribution, transportation, and other general characteristics of
      exosomes and then highlight the vital roles of exosomes in lymphomagenesis and
      disease progression, particularly from the perspective of immune dysfunction,
      virus infection, and therapeutic resistance mechanisms.
FAU - Xu, Biyu
AU  - Xu B
AD  - Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wang, Ting
AU  - Wang T
AD  - Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
SB  - IM
MH  - Blood Vessels/metabolism/pathology
MH  - Disease Progression
MH  - Exosomes/immunology/metabolism
MH  - Humans
MH  - *Immunity, Cellular
MH  - Lymphoma, B-Cell/*immunology/*metabolism/pathology
MH  - Stromal Cells/metabolism/pathology
MH  - Tumor Microenvironment/*immunology
OTO - NOTNLM
OT  - B-cell lymphomas
OT  - Microenvironment
OT  - drug resistance
OT  - exosomes
OT  - immunotherapy
OT  - lymphomagenesis
EDAT- 2017/06/18 06:00
MHDA- 2017/06/24 06:00
CRDT- 2017/06/17 06:00
AID - 10.1177/1010428317706227 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317706227. doi: 10.1177/1010428317706227.