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Achaete-scute complex homologue-1 promotes development of laryngocarcinoma via facilitating the epithelial-mesenchymal transformation.

Abstract Laryngeal cancer is one of the most common fatal cancers among head and neck carcinomas, whose mechanism, however, remains unclear. The proneural basic-helix-loop-helix protein achaete-scute complex homologue-1, a member of the basic helix-loop-helix family, plays a very important role in many cancers. This study aims to explore the clinical value and mechanism of achaete-scute complex homologue-1 in laryngeal cancer. Methods including Cell Counting Kit-8, flow cytometry, Transwell invasion assays, and scratch assay were adopted to further explore the bio-function of achaete-scute complex homologue-1, whose expression was examined in fresh and paraffin chip of laryngeal carcinoma tissues by means of western blot and immunohistochemistry, after the interference of achaete-scute complex homologue-1; achaete-scute complex homologue-1, an overexpression in laryngeal carcinoma whose carcinogenicity potential was confirmed via western blot, was correlative with T classification (p = 0.002), histological differentiation (p = 0.000), lymph node metastasis (p = 0.000), and poor survival (p = 0.000). Multivariate analysis shows that achaete-scute complex homologue-1 overexpression is an independent prognostic factor unfavorable to laryngeal carcinoma patients (p = 0.000). Moreover, knocking down achaete-scute complex homologue-1 expression could significantly suppress the proliferation, migration, and invasion of laryngeal carcinoma cell in vitro and disorder epithelial-mesenchymal transformation-associated protein expression. Achaete-scute complex homologue-1 plays an important role in the genesis and progression of laryngeal carcinoma and may act as a potential biomarker for therapeutic target and prognostic prediction.
PMID
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Authors

Mayor MeshTerms
Keywords

Laryngeal carcinoma

achaete-scute complex homologue-1

apoptosis

epithelial–mesenchymal transformation

migration

proliferation

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28618959
OWN - NLM
STAT- MEDLINE
DA  - 20170616
DCOM- 20170622
LR  - 20170622
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Achaete-scute complex homologue-1 promotes development of laryngocarcinoma via
      facilitating the epithelial-mesenchymal transformation.
PG  - 1010428317705752
LID - 10.1177/1010428317705752 [doi]
AB  - Laryngeal cancer is one of the most common fatal cancers among head and neck
      carcinomas, whose mechanism, however, remains unclear. The proneural
      basic-helix-loop-helix protein achaete-scute complex homologue-1, a member of the
      basic helix-loop-helix family, plays a very important role in many cancers. This 
      study aims to explore the clinical value and mechanism of achaete-scute complex
      homologue-1 in laryngeal cancer. Methods including Cell Counting Kit-8, flow
      cytometry, Transwell invasion assays, and scratch assay were adopted to further
      explore the bio-function of achaete-scute complex homologue-1, whose expression
      was examined in fresh and paraffin chip of laryngeal carcinoma tissues by means
      of western blot and immunohistochemistry, after the interference of achaete-scute
      complex homologue-1; achaete-scute complex homologue-1, an overexpression in
      laryngeal carcinoma whose carcinogenicity potential was confirmed via western
      blot, was correlative with T classification (p = 0.002), histological
      differentiation (p = 0.000), lymph node metastasis (p = 0.000), and poor survival
      (p = 0.000). Multivariate analysis shows that achaete-scute complex homologue-1
      overexpression is an independent prognostic factor unfavorable to laryngeal
      carcinoma patients (p = 0.000). Moreover, knocking down achaete-scute complex
      homologue-1 expression could significantly suppress the proliferation, migration,
      and invasion of laryngeal carcinoma cell in vitro and disorder
      epithelial-mesenchymal transformation-associated protein expression.
      Achaete-scute complex homologue-1 plays an important role in the genesis and
      progression of laryngeal carcinoma and may act as a potential biomarker for
      therapeutic target and prognostic prediction.
FAU - Ma, Huaci
AU  - Ma H
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Du, Xiaodong
AU  - Du X
AD  - 2 Department of Otolaryngology/Head and Neck Surgery, Affiliated Hospital of
      Jiangnan University, Wuxi, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Yin, Yong
AU  - Yin Y
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Qiu, Xiaoxia
AU  - Qiu X
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Da, Peng
AU  - Da P
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Yue, Huijun
AU  - Yue H
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Wu, Hao
AU  - Wu H
AD  - 1 Department of Otorhinolaryngology, Affiliated Hospital of Nantong University,
      Nantong, China.
FAU - Xu, Fenglei
AU  - Xu F
AD  - 3 Department of Otolaryngology/Head and Neck Surgery, The Second Hospital of
      Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (ASCL1 protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Basic Helix-Loop-Helix Transcription Factors/*biosynthesis/genetics
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Carcinoma/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics
OTO - NOTNLM
OT  - Laryngeal carcinoma
OT  - achaete-scute complex homologue-1
OT  - apoptosis
OT  - epithelial-mesenchymal transformation
OT  - migration
OT  - proliferation
EDAT- 2017/06/18 06:00
MHDA- 2017/06/24 06:00
CRDT- 2017/06/17 06:00
AID - 10.1177/1010428317705752 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317705752. doi: 10.1177/1010428317705752.