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Management of viral oral ulcers in children using Chinese herbal medicine: A report of two cases.

Abstract Viral oral ulcers are common presentations in pediatric clinics. Although self-limiting, painful ulcerative lesions and inflamed mucosa can decrease oral intake and lead to dehydration. Despite the widespread use of Chinese herbal medicine (CHM) for pediatric upper respiratory disease in Taiwan, there is little evidence for its effectiveness as an antipyretic or in aiding ulcer healing for children with viral oral ulcers. We report two cases of children who presented with viral oral ulcers to illustrate the potential efficacy of CHM treatment in recovery from herpangina (HA) and herpetic gingivostomatitis (HGS).
PMID
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Authors

Mayor MeshTerms

Drugs, Chinese Herbal

Oral Ulcer

Virus Diseases

Keywords

Chinese herbal medicine

Gan Lu Xiao Du Dan

Liang Ge San

Oral ulcer

Viral infection

Journal Title complementary therapies in medicine
Publication Year Start



 

PMID- 28619306
OWN - NLM
STAT- MEDLINE
DA  - 20170616
DCOM- 20170627
LR  - 20170627
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 32
DP  - 2017 Jun
TI  - Management of viral oral ulcers in children using Chinese herbal medicine: A
      report of two cases.
PG  - 61-65
LID - S0965-2299(17)30239-X [pii]
LID - 10.1016/j.ctim.2017.04.001 [doi]
AB  - OBJECTIVE: Viral oral ulcers are common presentations in pediatric clinics.
      Although self-limiting, painful ulcerative lesions and inflamed mucosa can
      decrease oral intake and lead to dehydration. Despite the widespread use of
      Chinese herbal medicine (CHM) for pediatric upper respiratory disease in Taiwan, 
      there is little evidence for its effectiveness as an antipyretic or in aiding
      ulcer healing for children with viral oral ulcers. We report two cases of
      children who presented with viral oral ulcers to illustrate the potential
      efficacy of CHM treatment in recovery from herpangina (HA) and herpetic
      gingivostomatitis (HGS). CLINICAL FEATURES AND OUTCOME: A 10-year-old girl with
      HA presented with an acute febrile illness associated with small vesicular or
      ulcerative lesions on the posterior oropharyngeal structures. The family refused 
      western medicine due to a prior anaphylactic skin rash when she had taken sulfa
      drugs. The other patient was a 4-year-old boy with complaints of painful ulcers
      and hemorrhagic crusts on the lips. He was diagnosed with HGS and had received
      ibuprofen and supportive treatments such as hydration and local anesthesia spray 
      for days, characterized by fever, anorexia, and nausea to no effect. Because the 
      patients were suffering from the damp-heat syndrome according to Traditional
      Chinese Medicine (TCM) differentiation, both were treated using the same herbal
      formulas powder prescription, named Liang Ge San (LGS) and Gan Lu Xiao Du Dan
      (GLXDD). After several days of CHM treatment, the oral ulcers were in regression.
      Follow-up of the frontal view in both patients showed satisfactory disappearance 
      of the sick furred tongue. CONCLUSIONS: The results of these case reports show
      that the early prescription of CHM is an effective modality of alternative
      treatment for viral oral ulcers. To our knowledge, this is the first report of
      CHM treatment hastening the recovery from febrile disease with viral oral ulcers 
      in Taiwan. Future experimental studies to determine the definitive mechanism and 
      clinical trials are warranted.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Lee, Yi-Chiao
AU  - Lee YC
AD  - Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
FAU - Wang, Ting-Hao
AU  - Wang TH
AD  - Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
FAU - Chen, Shih-Yu
AU  - Chen SY
AD  - Department of Pediatrics, E-DA Hospital and I-Shou University, Kaohsiung, Taiwan.
FAU - Lin, Hsiang-Ling
AU  - Lin HL
AD  - Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
FAU - Tsai, Ming-Yen
AU  - Tsai MY
AD  - Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:
      [email protected]
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170412
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - *Drugs, Chinese Herbal/administration & dosage/therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Mouth/pathology
MH  - *Oral Ulcer/drug therapy/pathology/virology
MH  - *Virus Diseases/drug therapy/pathology/virology
OTO - NOTNLM
OT  - Chinese herbal medicine
OT  - Gan Lu Xiao Du Dan
OT  - Liang Ge San
OT  - Oral ulcer
OT  - Viral infection
EDAT- 2017/06/18 06:00
MHDA- 2017/06/28 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/06/14 [received]
PHST- 2017/04/10 [revised]
PHST- 2017/04/10 [accepted]
AID - S0965-2299(17)30239-X [pii]
AID - 10.1016/j.ctim.2017.04.001 [doi]
PST - ppublish
SO  - Complement Ther Med. 2017 Jun;32:61-65. doi: 10.1016/j.ctim.2017.04.001. Epub
      2017 Apr 12.