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The relationship between the expressions of tumor associated fibroblasts Cav-1 and MCT4 and the prognosis of papillary carcinoma of breast.

Abstract The aim of this study was to evaluate the expression levels of Cav-1 and MCT4 in the tumor stroma CAFs. Immunohistochemical method was used to detect the expression of Cav-1 and MCT4 in 86 cases of IMPC, with 105 cases of non-specific invasive ductal carcinoma (IDC-NOS) as control. Their differential expression in different histological types were compared and relationship between the expression of Cav-1 and IMPC in the MCT4 and the main pathological features such as age, tumor size and histological grades were analyzed. The study confirmed that the loss expression of Cav-1 on CAFs and the up-regulation of MCT4 may be the possible mechanisms of CAFs in tumorigenesis, which may be one of the molecular mechanisms leading to the poor prognosis of IMPC. The expression of CAFs related proteins in tumor microenvironment suggested that CAFs could be used as the target of tumor therapy and provide new evidence for the treatment of breast cancer.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title pakistan journal of pharmaceutical sciences
Publication Year Start




PMID- 28625953
OWN - NLM
STAT- MEDLINE
DA  - 20170619
DCOM- 20170710
LR  - 20170713
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 30
IP  - 1 Suppl
DP  - 2017 Jan
TI  - The relationship between the expressions of tumor associated fibroblasts Cav-1
      and MCT4 and the prognosis of papillary carcinoma of breast.
PG  - 263-272
AB  - The aim of this study was to evaluate the expression levels of Cav-1 and MCT4 in 
      the tumor stroma CAFs. Immunohistochemical method was used to detect the
      expression of Cav-1 and MCT4 in 86 cases of IMPC, with 105 cases of non-specific 
      invasive ductal carcinoma (IDC-NOS) as control. Their differential expression in 
      different histological types were compared and relationship between the
      expression of Cav-1 and IMPC in the MCT4 and the main pathological features such 
      as age, tumor size and histological grades were analyzed. The study confirmed
      that the loss expression of Cav-1 on CAFs and the up-regulation of MCT4 may be
      the possible mechanisms of CAFs in tumorigenesis, which may be one of the
      molecular mechanisms leading to the poor prognosis of IMPC. The expression of
      CAFs related proteins in tumor microenvironment suggested that CAFs could be used
      as the target of tumor therapy and provide new evidence for the treatment of
      breast cancer.
FAU - Zhai, Yuanyuan
AU  - Zhai Y
AD  - Department of Galactophore, The Second Affiliated Hospital of Zhengzhou
      University, Zhengzhou, China.
FAU - Chai, Lijun
AU  - Chai L
AD  - Department of Galactophore, The Second Affiliated Hospital of Zhengzhou
      University, Zhengzhou, China.
FAU - Chen, Jianzhong
AU  - Chen J
AD  - Department of Galactophore, The Second Affiliated Hospital of Zhengzhou
      University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 0 (CAV1 protein, human)
RN  - 0 (Caveolin 1)
RN  - 0 (Monocarboxylic Acid Transporters)
RN  - 0 (Muscle Proteins)
RN  - 0 (SLC16A4 protein, human)
SB  - IM
MH  - Breast/metabolism/pathology
MH  - Breast Neoplasms/*metabolism/*pathology
MH  - Cancer-Associated Fibroblasts/*metabolism/pathology
MH  - Carcinogenesis/metabolism/pathology
MH  - Carcinoma, Papillary/*metabolism/*pathology
MH  - Caveolin 1/*metabolism
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Monocarboxylic Acid Transporters/*metabolism
MH  - Muscle Proteins/*metabolism
MH  - Prognosis
MH  - Tumor Microenvironment/physiology
MH  - Up-Regulation/physiology
EDAT- 2017/06/20 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/20 06:00
PST - ppublish
SO  - Pak J Pharm Sci. 2017 Jan;30(1 Suppl):263-272.