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Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial.

Abstract The 2013-2016 Ebola virus outbreak in West Africa was the most widespread in history. In response, alive attenuated recombinant vesicular stomatitis virus (rVSV) vaccine expressing Zaire Ebolavirus glycoprotein (rVSVΔG-ZEBOV-GP) was evaluated in humans.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title cmaj : canadian medical association journal = journal de l'association medicale canadienne
Publication Year Start




PMID- 28630358
OWN - NLM
STAT- MEDLINE
DA  - 20170620
DCOM- 20170712
LR  - 20170713
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 189
IP  - 24
DP  - 2017 Jun 19
TI  - Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus
      Ebola vaccine in healthy adults: a randomized clinical trial.
PG  - E819-E827
LID - 10.1503/cmaj.170074 [doi]
AB  - BACKGROUND: The 2013-2016 Ebola virus outbreak in West Africa was the most
      widespread in history. In response, alive attenuated recombinant vesicular
      stomatitis virus (rVSV) vaccine expressing Zaire Ebolavirus glycoprotein
      (rVSVDeltaG-ZEBOV-GP) was evaluated in humans. METHODS: In a phase 1, randomized,
      dose-ranging, observer-blind, placebo-controlled trial, healthy adults aged 18-65
      years were randomized into 4 groups of 10 to receive one of 3 vaccine doses or
      placebo. Follow-up visits spanned 180 days postvaccination for safety monitoring,
      immunogenicity testing and any rVSV virus shedding. RESULTS: Forty participants
      were injected with rVSVDeltaG-ZEBOV-GP vaccine (n = 30) or saline placebo (n =
      10). No serious adverse events related to the vaccine or participant withdrawals 
      were reported. Solicited adverse events during the 14-day follow-up period were
      mild to moderate and self-limited, with the exception of injection-site pain and 
      headache. Viremia following vaccination was transient and no longer detectable
      after study day 3, with no virus shedding in saliva or urine. All vaccinated
      participants developed serum immunoglobulin G (IgG), as measured by Ebola virus
      envelope glycoprotein-based enzyme-linked immunosorbent assay (ELISA).
      Immunogenicity was comparable across all dose groups, and sustained IgG titers
      were detectable through to the last visit, at study day 180. INTERPRETATION: In
      this phase 1 study, there were no safety concerns after a single dose of
      rVSVDeltaG-ZEBOV-GP vaccine. IgG ELISA showed persistent high titers at 180 days 
      postimmunization. There was a period of reactogenicity, but in general, the
      vaccine was well tolerated. This study provides evidence of the safety and
      immunogenicity of rVSVDeltaG-ZEBOV-GP vaccine and importance of its further
      investigation. Trial registration: Clinical-Trials.gov no., NCT02374385.
CI  - (c) 2017 Canadian Medical Association or its licensors.
FAU - ElSherif, May S
AU  - ElSherif MS
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Brown, Catherine
AU  - Brown C
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - MacKinnon-Cameron, Donna
AU  - MacKinnon-Cameron D
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Li, Li
AU  - Li L
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Racine, Trina
AU  - Racine T
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Alimonti, Judie
AU  - Alimonti J
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Rudge, Thomas L
AU  - Rudge TL
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Sabourin, Carol
AU  - Sabourin C
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Silvera, Peter
AU  - Silvera P
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Hooper, Jay W
AU  - Hooper JW
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Kwilas, Steven A
AU  - Kwilas SA
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Kilgore, Nicole
AU  - Kilgore N
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Badorrek, Christopher
AU  - Badorrek C
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Ramsey, W Jay
AU  - Ramsey WJ
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Heppner, D Gray
AU  - Heppner DG
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Kemp, Tracy
AU  - Kemp T
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Monath, Thomas P
AU  - Monath TP
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Nowak, Teresa
AU  - Nowak T
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - McNeil, Shelly A
AU  - McNeil SA
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Langley, Joanne M
AU  - Langley JM
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass.
FAU - Halperin, Scott A
AU  - Halperin SA
AD  - Canadian Center for Vaccinology (ElSherif, Brown, MacKinnon-Cameron, Li, McNeil, 
      Langley, Halperin), IWK Health Centre and Nova Scotia Health Authority, Dalhousie
      University, Halifax, NS; National Microbiology Laboratory (Racine, Alimonti),
      Winnipeg, Man.; Battelle Biomedical Research Center (Rudge, Sabourin), Columbus, 
      Ohio; United States Army Medical Research Institute of Infectious Disease
      (Silvera, Hooper, Kwilas), Fort Detrick, Md.; Joint Program Executive Office for 
      Chemical and Biological Defense Medical Countermeasure Systems' Joint Vaccine
      Acquisition Program (Kilgore, Badorrek), Fort Detrick, Md.; BioProtection
      Systems/NewLink Genetics Corporation (Ramsey, Heppner, Kemp, Monath), Ames, Iowa;
      Veristat LLC (Nowak), Southborough, Mass. [email protected]
CN  - Canadian Immunization Research Network
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Ebola Vaccines)
RN  - 0 (G protein, vesicular stomatitis virus)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (Viral Envelope Proteins)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/blood
MH  - Canada
MH  - Double-Blind Method
MH  - Ebola Vaccines/*administration & dosage
MH  - Ebolavirus
MH  - Female
MH  - Healthy Volunteers
MH  - Hemorrhagic Fever, Ebola/*prevention & control
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Membrane Glycoproteins/genetics/*immunology
MH  - Middle Aged
MH  - Regression Analysis
MH  - Vaccination/methods
MH  - Vaccines, Synthetic/administration & dosage
MH  - Vesicular stomatitis Indiana virus
MH  - Viral Envelope Proteins/genetics/*immunology
MH  - Young Adult
PMC - PMC5478408
COI - Competing interests: May ElSherif reports grants from the Canadian Institutes of 
      Health Research/Public Health Agency of Canada, during the conduct of the study. 
      Donna MacKinnon-Cameron reports an operating grant from the Canadian Institutes
      of Health Research/Public Health Agency of Canada, during the conduct of the
      study. Li Li reports an operating grant from the Canadian Institutes of Health
      Research/Public Health Agency of Canada, during the conduct of the study. Judie
      Alimonti reports personal fees from NewLink Genetics, outside the submitted work;
      and Her Majesty the Queen in right of Canada holds a patent related to the
      rVSVDeltaG-ZEBOV-GP vaccine (patents: EU 1 527 087; US 8 012 489; CA 2,493,142). 
      W. Jay Ramsey was an employee of NewLink Genetics during the conduct of the
      study, and reports personal fees as a salaried employee of NewLink Genetics,
      outside the submitted work. Donald Gray Heppner reports grants from the
      Department of Health and Human Services, during the conduct of the study and
      employment by NewLink Genetics Inc. (which is developing the vaccine described in
      this article), outside the submitted work. Tracy Kemp was an employee of NewLink 
      Genetics during the conduct of the study; she also reports personal fees as a
      salaried employee of NewLink Genetics, outside the submitted work. Thomas Monath 
      reports a grant from BARDA and the US Department of Health and Human Services,
      and financial support for study, personal salary and benefits from New-Link
      Genetics. Shelly McNeil reports an operating grant from the Canadian Institutes
      of Health Research/Public Health Agency of Canada, during the conduct of the
      study; and grants and personal fees from vaccine manufacturers (such as Merck,
      GlaxoSmithKline Biologicals, Sanofi Pasteur and Pfizer) outside the submitted
      work. Joanne Langley reports an operating grant from the Canadian Institutes of
      Health Research/Public Health Agency of Canada, during the conduct of the study, 
      as well as grants and personal fees from vaccine manufacturers (such as Merck,
      Glaxo-SmithKline Biologicals, Sanofi Pasteur, Pfizer, and Novartis) to conduct
      vaccine clinical trials, outside the submitted work. Scott Halperin reports an
      operating grant from the Canadian Institutes of Health Research/Public Health
      Agency of Canada, during the conduct of the study, and grants and personal fees
      from vaccine manufacturers (such as Merck, GlaxoSmithKline Biologicals, Sanofi
      Pasteur, Pfizer and Novartis) outside the submitted work. No other competing
      interests were declared.
EDAT- 2017/06/21 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/21 06:00
PHST- 2017/05/08 [accepted]
AID - 189/24/E819 [pii]
AID - 10.1503/cmaj.170074 [doi]
PST - ppublish
SO  - CMAJ. 2017 Jun 19;189(24):E819-E827. doi: 10.1503/cmaj.170074.