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First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.

Abstract Nivolumab has been associated with longer overall survival than docetaxel among patients with previously treated non-small-cell lung cancer (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with programmed death ligand 1 (PD-L1)-positive NSCLC.
PMID
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Authors

Mayor MeshTerms

Antineoplastic Agents

Keywords
Journal Title the new england journal of medicine
Publication Year Start




PMID- 28636851
OWN - NLM
STAT- MEDLINE
DA  - 20170621
DCOM- 20170623
LR  - 20170629
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 376
IP  - 25
DP  - 2017 Jun 22
TI  - First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.
PG  - 2415-2426
LID - 10.1056/NEJMoa1613493 [doi]
AB  - BACKGROUND: Nivolumab has been associated with longer overall survival than
      docetaxel among patients with previously treated non-small-cell lung cancer
      (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with
      chemotherapy in patients with programmed death ligand 1 (PD-L1)-positive NSCLC.
      METHODS: We randomly assigned, in a 1:1 ratio, patients with untreated stage IV
      or recurrent NSCLC and a PD-L1 tumor-expression level of 1% or more to receive
      nivolumab (administered intravenously at a dose of 3 mg per kilogram of body
      weight once every 2 weeks) or platinum-based chemotherapy (administered once
      every 3 weeks for up to six cycles). Patients receiving chemotherapy could cross 
      over to receive nivolumab at the time of disease progression. The primary end
      point was progression-free survival, as assessed by means of blinded independent 
      central review, among patients with a PD-L1 expression level of 5% or more.
      RESULTS: Among the 423 patients with a PD-L1 expression level of 5% or more, the 
      median progression-free survival was 4.2 months with nivolumab versus 5.9 months 
      with chemotherapy (hazard ratio for disease progression or death, 1.15; 95%
      confidence interval [CI], 0.91 to 1.45; P=0.25), and the median overall survival 
      was 14.4 months versus 13.2 months (hazard ratio for death, 1.02; 95% CI, 0.80 to
      1.30). A total of 128 of 212 patients (60%) in the chemotherapy group received
      nivolumab as subsequent therapy. Treatment-related adverse events of any grade
      occurred in 71% of the patients who received nivolumab and in 92% of those who
      received chemotherapy. Treatment-related adverse events of grade 3 or 4 occurred 
      in 18% of the patients who received nivolumab and in 51% of those who received
      chemotherapy. CONCLUSIONS: Nivolumab was not associated with significantly longer
      progression-free survival than chemotherapy among patients with previously
      untreated stage IV or recurrent NSCLC with a PD-L1 expression level of 5% or
      more. Overall survival was similar between groups. Nivolumab had a favorable
      safety profile, as compared with chemotherapy, with no new or unexpected safety
      signals. (Funded by Bristol-Myers Squibb and others; CheckMate 026
      ClinicalTrials.gov number, NCT02041533 .).
FAU - Carbone, David P
AU  - Carbone DP
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Reck, Martin
AU  - Reck M
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Paz-Ares, Luis
AU  - Paz-Ares L
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Creelan, Benjamin
AU  - Creelan B
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Horn, Leora
AU  - Horn L
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Steins, Martin
AU  - Steins M
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Felip, Enriqueta
AU  - Felip E
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - van den Heuvel, Michel M
AU  - van den Heuvel MM
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Ciuleanu, Tudor-Eliade
AU  - Ciuleanu TE
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Badin, Firas
AU  - Badin F
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Ready, Neal
AU  - Ready N
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Hiltermann, T Jeroen N
AU  - Hiltermann TJN
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Nair, Suresh
AU  - Nair S
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Juergens, Rosalyn
AU  - Juergens R
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Peters, Solange
AU  - Peters S
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Minenza, Elisa
AU  - Minenza E
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Wrangle, John M
AU  - Wrangle JM
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Rodriguez-Abreu, Delvys
AU  - Rodriguez-Abreu D
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Borghaei, Hossein
AU  - Borghaei H
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Blumenschein, George R Jr
AU  - Blumenschein GR Jr
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Villaruz, Liza C
AU  - Villaruz LC
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Havel, Libor
AU  - Havel L
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Krejci, Jana
AU  - Krejci J
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Corral Jaime, Jesus
AU  - Corral Jaime J
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Chang, Han
AU  - Chang H
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Geese, William J
AU  - Geese WJ
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Bhagavatheeswaran, Prabhu
AU  - Bhagavatheeswaran P
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Chen, Allen C
AU  - Chen AC
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
FAU - Socinski, Mark A
AU  - Socinski MA
AD  - From the Ohio State University Comprehensive Cancer Center, Columbus (D.P.C.);
      LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung 
      Research, Grosshansdorf (M.R.), and Thoraxklinik, Heidelberg University Hospital,
      Heidelberg (M.S.) - both in Germany; Hospital Universitario Doce de Octubre,
      Centro Nacional de Investigaciones Oncologicas and Universidad Complutense,
      Madrid (L.P.-A., J.C.J.), Vall d'Hebron University Hospital, Barcelona (E.F.),
      and Hospital Universitario Insular de Gran Canaria, Las Palmas (D.R.-A.) - all in
      Spain; H. Lee Moffitt Cancer Center, Tampa, FL (B.C.); Vanderbilt University
      Medical Center, Nashville (L. Horn); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam
      (M.M.H.), and University of Groningen, Universitair Medisch Centrum Groningen,
      Groningen (T.J.N.H.) - both in the Netherlands; Prof. Dr. Ion Chiricuta Institute
      of Oncology and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca,
      Romania (T.-E.C.); Baptist Health Lexington, Lexington, KY (F.B.); Duke
      University, Durham, NC (N.R.); Lehigh Valley Health Network, Allentown (S.N.),
      Fox Chase Cancer Center, Philadelphia (H.B.), and University of Pittsburgh
      Medical Center Cancer Center, Pittsburgh (L.C.V., M.A.S.) - all in Pennsylvania; 
      Juravinski Cancer Centre, Hamilton, ON, Canada (R.J.); Oncology Department,
      Lausanne University Hospital, Lausanne, Switzerland (S.P.); Santa Maria Hospital,
      Terni, Italy (E.M.); Hollings Cancer Center, Charleston, SC (J.M.W.); Department 
      of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson
      Cancer Center, Houston (G.R.B.); Klinika Pneumologie a Hrudni Chirurgie,
      Nemocnice Na Bulovce, Prague, Czech Republic (L. Havel, J.K.); and Bristol-Myers 
      Squibb, Princeton, NJ (H.C., W.J.G., P.B., A.C.C.).
CN  - CheckMate 026 Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT02041533
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - K12 CA157688/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Antigens, CD274)
RN  - 0 (Antineoplastic Agents)
SB  - AIM
SB  - IM
CON - N Engl J Med. 2017 Jun 22;376(25):2483-2485. PMID: 28636845
MH  - Antigens, CD274/metabolism
MH  - *Antineoplastic Agents
MH  - Carcinoma, Non-Small-Cell Lung/*chemically induced
MH  - Disease-Free Survival
MH  - Humans
MH  - Lung Neoplasms/chemically induced
IR  - Lupinacci L
FIR - Lupinacci, Lorena
IR  - Martin C
FIR - Martin, Claudio
IR  - Pilnik N
FIR - Pilnik, Norma
IR  - Richardet ME
FIR - Richardet, Martin Eduardo
IR  - Varela MS
FIR - Varela, Mirta Susana
IR  - Adams J
FIR - Adams, Jacqueline
IR  - Boyer M
FIR - Boyer, Michael
IR  - John T
FIR - John, Thomas
IR  - Moore M
FIR - Moore, Melissa
IR  - O`Byrne K
FIR - O`Byrne, Kenneth
IR  - Eckmayr J
FIR - Eckmayr, Josef
IR  - Pirker R
FIR - Pirker, Robert
IR  - Decoster L
FIR - Decoster, Lore
IR  - van Meerbeeck J
FIR - van Meerbeeck, Jan
IR  - Vansteenkiste J
FIR - Vansteenkiste, Johan
IR  - Surmont V
FIR - Surmont, Veerle
IR  - Barrios CH
FIR - Barrios, Carlos Henrique
IR  - Franke FA
FIR - Franke, Fabio Andre
IR  - Pinto G
FIR - Pinto, Gustavo
IR  - Blais N
FIR - Blais, Normand
IR  - Foley MC
FIR - Foley, Marie-Claude
IR  - Juergens R
FIR - Juergens, Rosalyn
IR  - Leighl N
FIR - Leighl, Natasha
IR  - Morris DG
FIR - Morris, Don G
IR  - Havel L
FIR - Havel, Libor
IR  - Kolek V
FIR - Kolek, Vitezslav
IR  - Krejci J
FIR - Krejci, Jana
IR  - Reiterer P
FIR - Reiterer, Pavel
IR  - Roubec J
FIR - Roubec, Jaromir
IR  - Ahvonen J
FIR - Ahvonen, Jarkko
IR  - Jekunen A
FIR - Jekunen, Antti
IR  - Maasilta P
FIR - Maasilta, Paula
IR  - Barlesi F
FIR - Barlesi, Fabrice
IR  - Dansen E
FIR - Dansen, Eric
IR  - Fraboulet G
FIR - Fraboulet, Gislaine
IR  - Lena H
FIR - Lena, Herve
IR  - Mennecier B
FIR - Mennecier, Bertrand
IR  - Zalcman G
FIR - Zalcman, Gerard
IR  - Frickhofen N
FIR - Frickhofen, Norbert
IR  - Kohlhaeufl M
FIR - Kohlhaeufl, Martin
IR  - Reck M
FIR - Reck, Martin
IR  - Repp R
FIR - Repp, Roland
IR  - Steins M
FIR - Steins, Martin
IR  - Wolf J
FIR - Wolf, Juergen
IR  - Agelaki S
FIR - Agelaki, Sofia
IR  - Syrigos K
FIR - Syrigos, Konstantinos
IR  - Albert I
FIR - Albert, Istvan
IR  - Ostoros G
FIR - Ostoros, Gyula
IR  - Szilasi M
FIR - Szilasi, Maria
IR  - Cappuzzo F
FIR - Cappuzzo, Federico
IR  - Crino L
FIR - Crino, Lucio
IR  - De Marinis F
FIR - De Marinis, Filippo
IR  - Gridelli C
FIR - Gridelli, Cesare
IR  - Morabito A
FIR - Morabito, Alessandro
IR  - Roila F
FIR - Roila, Fausto
IR  - Atagi S
FIR - Atagi, Shinji
IR  - Fujita S
FIR - Fujita, Shiro
IR  - Hida T
FIR - Hida, Toyoaki
IR  - Hirashima T
FIR - Hirashima, Tomonori
IR  - Maemondo M
FIR - Maemondo, Makoto
IR  - Minato K
FIR - Minato, Koichi
IR  - Nakagawa K
FIR - Nakagawa, Kazuhiko
IR  - Nishio M
FIR - Nishio, Makoto
IR  - Nogami N
FIR - Nogami, Naoyuki
IR  - Ohe Y
FIR - Ohe, Yuichiro
IR  - Saka H
FIR - Saka, Hideo
IR  - Sakai H
FIR - Sakai, Hiroshi
IR  - Satouchi M
FIR - Satouchi, Miyako
IR  - Takeda K
FIR - Takeda, Koji
IR  - Tanaka H
FIR - Tanaka, Hiroshi
IR  - Yamamoto N
FIR - Yamamoto, Nobuyuki
IR  - Arrieta-Rodriguez O
FIR - Arrieta-Rodriguez, Oscar
IR  - De la Mora Jimenez E
FIR - De la Mora Jimenez, Emanuel
IR  - Flores Wilbert V
FIR - Flores Wilbert, Victoria
IR  - Aerts J
FIR - Aerts, Joachim
IR  - Hiltermann TJN
FIR - Hiltermann, T Jeroen N
IR  - Van Den Heuvel M
FIR - Van Den Heuvel, Michel
IR  - Chmielowska E
FIR - Chmielowska, Ewa
IR  - Czyzewicz G
FIR - Czyzewicz, Grzegorz
IR  - Gabrys J
FIR - Gabrys, Jacek
IR  - Kalinka-Warzocha E
FIR - Kalinka-Warzocha, Ewa
IR  - Pluzanski A
FIR - Pluzanski, Adam
IR  - Kim HR
FIR - Kim, Hye Ryun
IR  - Kim SW
FIR - Kim, Sang-We
IR  - Park K
FIR - Park, Keunchil
IR  - Cainap C
FIR - Cainap, Calin
IR  - Ciuleanu TE
FIR - Ciuleanu, Tudor-Eliade
IR  - Ghizdavescu D
FIR - Ghizdavescu, Doru
IR  - Blasco A
FIR - Blasco, Ana
IR  - Corral Jaime J
FIR - Corral Jaime, Jesus
IR  - De Castro J
FIR - De Castro, Javier
IR  - Felip E
FIR - Felip, Enriqueta
IR  - Paz-Ares L
FIR - Paz-Ares, Luis
IR  - Rodriguez Abreu D
FIR - Rodriguez Abreu, Delvys
IR  - Trigo J
FIR - Trigo, Jose
IR  - Kolbeck KG
FIR - Kolbeck, Karl-Gustav
IR  - Lindskog M
FIR - Lindskog, Magnus
IR  - Curioni-Fontecedro A
FIR - Curioni-Fontecedro, Alessandra
IR  - Mark M
FIR - Mark, Michael
IR  - Peters S
FIR - Peters, Solange
IR  - Chen YM
FIR - Chen, Yuh-Min
IR  - Karaca H
FIR - Karaca, Halit
IR  - Chao D
FIR - Chao, David
IR  - Mulatero C
FIR - Mulatero, Clive
IR  - Summers Y
FIR - Summers, Yvonne
IR  - Arledge S
FIR - Arledge, Sherri
IR  - Badin F
FIR - Badin, Firas
IR  - Batus M
FIR - Batus, Marta
IR  - Blumenschein G
FIR - Blumenschein, George
IR  - Borghaei H
FIR - Borghaei, Hossein
IR  - Camidge R
FIR - Camidge, Ross
IR  - Boyd T
FIR - Boyd, Thomas
IR  - Brahmer J
FIR - Brahmer, Julie
IR  - Carbone D
FIR - Carbone, David
IR  - Cetnar J
FIR - Cetnar, Jeremy
IR  - Chachoua A
FIR - Chachoua, Abraham
IR  - Chaft J
FIR - Chaft, Jamie
IR  - Chen H
FIR - Chen, Hongbin
IR  - Creelan B
FIR - Creelan, Benjamin
IR  - Gainor J
FIR - Gainor, Justin
IR  - Gettinger S
FIR - Gettinger, Scott
IR  - Gerber DE
FIR - Gerber, David E
IR  - Horn L
FIR - Horn, Leora
IR  - Kaywin P
FIR - Kaywin, Paul
IR  - Kessler R
FIR - Kessler, Robert
IR  - Langer CJ
FIR - Langer, Corey J
IR  - McCracken J
FIR - McCracken, Joseph
IR  - Nair S
FIR - Nair, Suresh
IR  - Oyola R
FIR - Oyola, Raul
IR  - Pillai R
FIR - Pillai, Rathi
IR  - Quddus F
FIR - Quddus, Fahd
IR  - Rangachari D
FIR - Rangachari, Deepa
IR  - Ready N
FIR - Ready, Neal
IR  - Reynolds C
FIR - Reynolds, Craig
IR  - Rosenberg R
FIR - Rosenberg, Richard
IR  - Sharma N
FIR - Sharma, Neelesh
IR  - Stinchcombe T
FIR - Stinchcombe, Thomas
IR  - Villaruz L
FIR - Villaruz, Liza
IR  - Wakelee H
FIR - Wakelee, Heather
IR  - Wrangle J
FIR - Wrangle, John
EDAT- 2017/06/22 06:00
MHDA- 2017/06/24 06:00
CRDT- 2017/06/22 06:00
AID - 10.1056/NEJMoa1613493 [doi]
PST - ppublish
SO  - N Engl J Med. 2017 Jun 22;376(25):2415-2426. doi: 10.1056/NEJMoa1613493.