PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway.

Abstract Emerging evidence suggests that microRNAs are critical regulators of cancer development and progression. MicroRNA-195 has been reported as a cancer-related microRNA in many human cancers. However, the role of microRNA-195 in pancreatic cancer remains largely unknown. Here, we show that microRNA-195 is downregulated in pancreatic cancer tissues and cell line. Also, we show that overexpression of microRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells, whereas suppression of microRNA-195 promotes proliferation and invasion. We show that microRNA-195 directly targets the fatty acid synthase enzyme and negatively regulates the expression of fatty acid synthase. Also, we show that fatty acid synthase expression is inversely correlated with microRNA-195 expression in pancreatic cancer tissues. Moreover, our results show that microRNA-195 inhibits Wnt signaling in pancreatic cancer cells. By restoring fatty acid synthase expression, we were able to reverse the antitumor effects of microRNA-195 in pancreatic cancer cells. Taken together, our findings show that microRNA-195 inhibits pancreatic cancer cell proliferation and invasion by regulating the fatty acid synthase/Wnt signaling pathway, suggesting a tumor suppressive role for microRNA-195 in the development and progression of pancreatic cancer. Thus, inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic approach for the treatment of pancreatic cancer.
PMID
Related Publications

MEF2D/Wnt/β-catenin pathway regulates the proliferation of gastric cancer cells and is regulated by microRNA-19.

Over-expression of microRNA-940 promotes cell proliferation by targeting GSK3β and sFRP1 in human pancreatic carcinoma.

MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.

MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1.

MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway.

Authors

Mayor MeshTerms
Keywords

Fatty acid synthase

Wnt

microRNA-195

pancreatic cancer

proliferation

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28639885
OWN - NLM
STAT- MEDLINE
DA  - 20170622
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells
      by targeting the fatty acid synthase/Wnt signaling pathway.
PG  - 1010428317711324
LID - 10.1177/1010428317711324 [doi]
AB  - Emerging evidence suggests that microRNAs are critical regulators of cancer
      development and progression. MicroRNA-195 has been reported as a cancer-related
      microRNA in many human cancers. However, the role of microRNA-195 in pancreatic
      cancer remains largely unknown. Here, we show that microRNA-195 is downregulated 
      in pancreatic cancer tissues and cell line. Also, we show that overexpression of 
      microRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells, 
      whereas suppression of microRNA-195 promotes proliferation and invasion. We show 
      that microRNA-195 directly targets the fatty acid synthase enzyme and negatively 
      regulates the expression of fatty acid synthase. Also, we show that fatty acid
      synthase expression is inversely correlated with microRNA-195 expression in
      pancreatic cancer tissues. Moreover, our results show that microRNA-195 inhibits 
      Wnt signaling in pancreatic cancer cells. By restoring fatty acid synthase
      expression, we were able to reverse the antitumor effects of microRNA-195 in
      pancreatic cancer cells. Taken together, our findings show that microRNA-195
      inhibits pancreatic cancer cell proliferation and invasion by regulating the
      fatty acid synthase/Wnt signaling pathway, suggesting a tumor suppressive role
      for microRNA-195 in the development and progression of pancreatic cancer. Thus,
      inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic
      approach for the treatment of pancreatic cancer.
FAU - Xu, Zhichao
AU  - Xu Z
AD  - 1 Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, P.R. China.
FAU - Li, Chunli
AU  - Li C
AD  - 2 Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, P.R. China.
FAU - Qu, Hui
AU  - Qu H
AD  - 1 Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, P.R. China.
FAU - Li, Huiling
AU  - Li H
AD  - 1 Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, P.R. China.
FAU - Gu, Qiaoyan
AU  - Gu Q
AD  - 3 Department of Gastroenterology, The Affiliated Hospital of Yan'an University,
      Yan'an, P.R. China.
FAU - Xu, Jing
AU  - Xu J
AD  - 1 Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (MIRN195 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (beta Catenin)
RN  - EC 2.3.1.85 (FASN protein, human)
RN  - EC 2.3.1.85 (Fatty Acid Synthase, Type I)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation/*genetics
MH  - Fatty Acid Synthase, Type I/biosynthesis/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Pancreatic Neoplasms/*genetics/pathology
MH  - Wnt Signaling Pathway/genetics
MH  - beta Catenin/genetics
OTO - NOTNLM
OT  - Fatty acid synthase
OT  - Wnt
OT  - microRNA-195
OT  - pancreatic cancer
OT  - proliferation
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/23 06:00
AID - 10.1177/1010428317711324 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317711324. doi: 10.1177/1010428317711324.