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MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression.

Abstract MicroRNAs play an important role in regulating post-transcriptional gene expression in the progression of various human cancers. In this study, we investigated the role of microRNA-557 in human lung cancer cells. The molecular mechanism of microRNA-557 was also clarified in the proliferation and invasion of human lung cancer cells. Our results showed microRNA-557 levels were obviously decreased in clinical lung cancer specimens and lung cancer cell lines. Cell viability of A549 and NCI-H460 cells transfected with microRNA-557 mimics was significantly decreased than those transfected with negative control mimics. MicroRNA-557 promoted cell death of A549 and NCI-H460 but did not affect the cell apoptosis of lung cancer cells. Overexpression of microRNA-557 inhibited cell invasion of A549 and NCI-H460 cells. TargetScan analysis showed that microRNA-557 might target 3' untranslated region of lymphocyte enhancement factor 1, and the western blotting results showed that transfection of microRNA-557 mimics significantly decreased the levels of lymphocyte enhancement factor 1 in A549 and H460 cells. MicroRNA-557 might work as a tumor suppressor by negatively regulating the expression of lymphocyte enhancement factor 1 in lung cancer cells.
PMID
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Authors

Mayor MeshTerms
Keywords

MicroRNA-557

cell apoptosis

invasion

lung cancer

proliferation

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28639890
OWN - NLM
STAT- MEDLINE
DA  - 20170622
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - MiR-557 works as a tumor suppressor in human lung cancers by negatively
      regulating LEF1 expression.
PG  - 1010428317709467
LID - 10.1177/1010428317709467 [doi]
AB  - MicroRNAs play an important role in regulating post-transcriptional gene
      expression in the progression of various human cancers. In this study, we
      investigated the role of microRNA-557 in human lung cancer cells. The molecular
      mechanism of microRNA-557 was also clarified in the proliferation and invasion of
      human lung cancer cells. Our results showed microRNA-557 levels were obviously
      decreased in clinical lung cancer specimens and lung cancer cell lines. Cell
      viability of A549 and NCI-H460 cells transfected with microRNA-557 mimics was
      significantly decreased than those transfected with negative control mimics.
      MicroRNA-557 promoted cell death of A549 and NCI-H460 but did not affect the cell
      apoptosis of lung cancer cells. Overexpression of microRNA-557 inhibited cell
      invasion of A549 and NCI-H460 cells. TargetScan analysis showed that microRNA-557
      might target 3' untranslated region of lymphocyte enhancement factor 1, and the
      western blotting results showed that transfection of microRNA-557 mimics
      significantly decreased the levels of lymphocyte enhancement factor 1 in A549 and
      H460 cells. MicroRNA-557 might work as a tumor suppressor by negatively
      regulating the expression of lymphocyte enhancement factor 1 in lung cancer
      cells.
FAU - Qiu, Jiayong
AU  - Qiu J
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Hao, Yingying
AU  - Hao Y
AD  - 2 Department of Infectious Diseases, The First Affiliated Hospital, and College
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Huang, Shenshen
AU  - Huang S
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Ma, Yaqing
AU  - Ma Y
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Li, Xiaofang
AU  - Li X
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Li, Danyang
AU  - Li D
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
FAU - Mao, Yimin
AU  - Mao Y
AD  - 1 Department of Respiratory Medicine, The First Affiliated Hospital, and College 
      of Clinical Medicine of Henan University of Science and Technology, Luoyang,
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (LEF1 protein, human)
RN  - 0 (Lymphoid Enhancer-Binding Factor 1)
RN  - 0 (MIRN557 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - A549 Cells
MH  - Apoptosis/genetics
MH  - Cell Movement/genetics
MH  - Cell Proliferation/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Lung Neoplasms/*genetics/pathology
MH  - Lymphoid Enhancer-Binding Factor 1/*biosynthesis/genetics
MH  - MicroRNAs/*genetics
MH  - Middle Aged
OTO - NOTNLM
OT  - MicroRNA-557
OT  - cell apoptosis
OT  - invasion
OT  - lung cancer
OT  - proliferation
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/23 06:00
AID - 10.1177/1010428317709467 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317709467. doi: 10.1177/1010428317709467.