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Antitumor activity of a Rhodococcus sp. Lut0910 isolated from polluted soil.

Abstract The actinomycetes strain, lut0910, was isolated from polluted soil and identified as the Rhodococcus species with 99% similarity based on the sequence analysis of 16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro antitumor activity. The treatment of two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract caused the delay in cell propagation in a dose-dependent manner with an IC50 of 73.39 and 33.09 µg/mL, respectively. Also, the oral administration of lut0910 extract to the mice with a solid tumor resulted in the inhibition of tumor growth in comparison with a placebo group. The thymus and spleen indexes were significantly increased in mice groups treated with the lut0910 extract. The histopathological changes of the tumor tissues showed that there were massive necrotic areas in the tumor tissues after treatment with different doses of the lut0910 extract. Our result would provide a new way and potent source for development of new anticancer agent from the polluted environment.
PMID
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Authors

Mayor MeshTerms
Keywords

Actinomycetes

Rhodococcus sp.

antitumor activity

polluted soil

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28639891
OWN - NLM
STAT- MEDLINE
DA  - 20170622
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Antitumor activity of a Rhodococcus sp. Lut0910 isolated from polluted soil.
PG  - 1010428317711661
LID - 10.1177/1010428317711661 [doi]
AB  - The actinomycetes strain, lut0910, was isolated from polluted soil and identified
      as the Rhodococcus species with 99% similarity based on the sequence analysis of 
      16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro
      antitumor activity. The treatment of two human cancer cell lines, hepatocellular 
      carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract
      caused the delay in cell propagation in a dose-dependent manner with an IC50 of
      73.39 and 33.09 microg/mL, respectively. Also, the oral administration of lut0910
      extract to the mice with a solid tumor resulted in the inhibition of tumor growth
      in comparison with a placebo group. The thymus and spleen indexes were
      significantly increased in mice groups treated with the lut0910 extract. The
      histopathological changes of the tumor tissues showed that there were massive
      necrotic areas in the tumor tissues after treatment with different doses of the
      lut0910 extract. Our result would provide a new way and potent source for
      development of new anticancer agent from the polluted environment.
FAU - Zhang, Xin-Guo
AU  - Zhang XG
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
FAU - Liu, Zi-Yu
AU  - Liu ZY
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
FAU - Liu, Jin-Wen
AU  - Liu JW
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
FAU - Zeng, Yan-Long
AU  - Zeng YL
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
FAU - Guo, Guang-Jun
AU  - Guo GJ
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
FAU - Sun, Qiao-Yun
AU  - Sun QY
AD  - 1 School of Life Science and Engineering, Lanzhou University of Technology,
      Gansu, P.R. China.
AD  - 2 Key Laboratory of Screening and Processing in New Tibetan Medicine of Gansu
      Province, Gansu, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Cell Extracts)
RN  - 0 (RNA, Ribosomal, 16S)
RN  - 0 (Soil Pollutants)
SB  - IM
MH  - Animals
MH  - Carcinoma, Hepatocellular/*drug therapy/pathology
MH  - Cell Extracts/*administration & dosage/chemistry
MH  - Female
MH  - Hep G2 Cells
MH  - Humans
MH  - Liver Neoplasms/*drug therapy/pathology
MH  - Mice
MH  - RNA, Ribosomal, 16S/genetics
MH  - Rhodococcus/chemistry
MH  - Soil Pollutants/chemistry
MH  - Uterine Cervical Neoplasms/*drug therapy/pathology
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Actinomycetes
OT  - Rhodococcus sp.
OT  - antitumor activity
OT  - polluted soil
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/23 06:00
AID - 10.1177/1010428317711661 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317711661. doi: 10.1177/1010428317711661.