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Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.

Abstract Gastric cancer is one of the most common tumors of the digestive system. Here, analysis of the expression profiles of circular RNAs in advanced gastric adenocarcinoma and adjacent normal mucosa tissues revealed differential expression of 306 circular RNAs, among which 273 were predicted to exert regulatory effects on target microRNAs. The downstream pathway networks of circular RNA-microRNA were mapped and the node genes were identified. In particular, we found that the expression of hsa_circ_0058246 was elevated in tumor specimens of patients with poor clinical outcomes. Our collective findings indicate that circular RNAs play a critical role in gastric cancer tumorigenesis. Data from this study provide a new perspective on the molecular pathways underlying metastasis and recurrence of gastric cancer and highlight potential therapeutic targets that may contribute to more effective diagnosis and treatment of the disease.
PMID
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Authors

Mayor MeshTerms
Keywords

Gastric cancer

Kyoto Encyclopedia of Genes and Genomes

circular RNA

gene ontology

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28639908
OWN - NLM
STAT- MEDLINE
DA  - 20170622
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Circular RNAs play an important role in late-stage gastric cancer: Circular RNA
      expression profiles and bioinformatics analyses.
PG  - 1010428317705850
LID - 10.1177/1010428317705850 [doi]
AB  - Gastric cancer is one of the most common tumors of the digestive system. Here,
      analysis of the expression profiles of circular RNAs in advanced gastric
      adenocarcinoma and adjacent normal mucosa tissues revealed differential
      expression of 306 circular RNAs, among which 273 were predicted to exert
      regulatory effects on target microRNAs. The downstream pathway networks of
      circular RNA-microRNA were mapped and the node genes were identified. In
      particular, we found that the expression of hsa_circ_0058246 was elevated in
      tumor specimens of patients with poor clinical outcomes. Our collective findings 
      indicate that circular RNAs play a critical role in gastric cancer tumorigenesis.
      Data from this study provide a new perspective on the molecular pathways
      underlying metastasis and recurrence of gastric cancer and highlight potential
      therapeutic targets that may contribute to more effective diagnosis and treatment
      of the disease.
FAU - Fang, Yantian
AU  - Fang Y
AD  - Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai 
      Cancer Center, Shanghai, China.
FAU - Ma, Minzhe
AU  - Ma M
AD  - Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai 
      Cancer Center, Shanghai, China.
FAU - Wang, Jiangli
AU  - Wang J
AD  - Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai 
      Cancer Center, Shanghai, China.
FAU - Liu, Xiaowen
AU  - Liu X
AD  - Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai 
      Cancer Center, Shanghai, China.
FAU - Wang, Yanong
AU  - Wang Y
AD  - Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai 
      Cancer Center, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, circular)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Carcinogenesis/genetics
MH  - Female
MH  - Gastric Mucosa/metabolism/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*genetics/pathology
MH  - RNA/*biosynthesis/genetics
MH  - Stomach Neoplasms/*genetics/pathology
OTO - NOTNLM
OT  - Gastric cancer
OT  - Kyoto Encyclopedia of Genes and Genomes
OT  - circular RNA
OT  - gene ontology
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/23 06:00
AID - 10.1177/1010428317705850 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317705850. doi: 10.1177/1010428317705850.