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MicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through directly targeting specificity protein 1.

Abstract Cervical cancer is the fourth most commonly occurring malignancy in females worldwide. Accumulated studies have demonstrated that the aberrant expression of microRNAs plays important roles in tumorigenesis and tumor development and potentially serves as therapeutic targets in various cancers including cervical cancer. Therefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease. In this study, we aimed to detect microRNA-337 expression pattern and investigate the biological roles of microRNA-337 in the regulation of the malignant phenotypes of cervical cancer and its underlying mechanisms. We found that microRNA-337 expression was significantly downregulated in cervical cancer tissues and cell lines. In addition, its aberrant expression levels were positively correlated with tumor size, International Federation of Gynecology and Obstetrics stage, and lymph node metastasis of cervical cancer. The ectopic expression of microRNA-337 suppressed cell proliferation and invasion of cervical cancer in vitro. Furthermore, specificity protein 1 was identified as a direct target of microRNA-337 in cervical cancer. The expression of specificity protein 1 increased in cervical cancer tissues and negatively correlated with microRNA-337 expression level. Moreover, rescue experiments revealed that upregulation of specificity protein 1 could rescue the effects of microRNA-337 on cervical cancer cells. Taken together, these findings collectively demonstrate that microRNA-337 exerts its tumor-suppressing roles in cervical cancer by directly targeting specificity protein 1, thereby indicating a potential novel potential therapeutic target for patients with cervical cancer.
PMID
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Authors

Mayor MeshTerms
Keywords

MicroRNA-337

cell invasion

cell proliferation

cervical cancer

specificity protein 1

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28641487
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - MicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through 
      directly targeting specificity protein 1.
PG  - 1010428317711323
LID - 10.1177/1010428317711323 [doi]
AB  - Cervical cancer is the fourth most commonly occurring malignancy in females
      worldwide. Accumulated studies have demonstrated that the aberrant expression of 
      microRNAs plays important roles in tumorigenesis and tumor development and
      potentially serves as therapeutic targets in various cancers including cervical
      cancer. Therefore, the identification of specific microRNAs contributed to
      cervical cancer formation and progression would provide critical clues for the
      treatments for patients with this disease. In this study, we aimed to detect
      microRNA-337 expression pattern and investigate the biological roles of
      microRNA-337 in the regulation of the malignant phenotypes of cervical cancer and
      its underlying mechanisms. We found that microRNA-337 expression was
      significantly downregulated in cervical cancer tissues and cell lines. In
      addition, its aberrant expression levels were positively correlated with tumor
      size, International Federation of Gynecology and Obstetrics stage, and lymph node
      metastasis of cervical cancer. The ectopic expression of microRNA-337 suppressed 
      cell proliferation and invasion of cervical cancer in vitro. Furthermore,
      specificity protein 1 was identified as a direct target of microRNA-337 in
      cervical cancer. The expression of specificity protein 1 increased in cervical
      cancer tissues and negatively correlated with microRNA-337 expression level.
      Moreover, rescue experiments revealed that upregulation of specificity protein 1 
      could rescue the effects of microRNA-337 on cervical cancer cells. Taken
      together, these findings collectively demonstrate that microRNA-337 exerts its
      tumor-suppressing roles in cervical cancer by directly targeting specificity
      protein 1, thereby indicating a potential novel potential therapeutic target for 
      patients with cervical cancer.
FAU - Dong, Wei
AU  - Dong W
AD  - 1 Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao 
      University, Yantai, Shandong Province, P.R. China.
AD  - 2 Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R. China.
FAU - Li, Baosheng
AU  - Li B
AD  - 2 Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R. China.
FAU - Wang, Juan
AU  - Wang J
AD  - 2 Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R. China.
FAU - Song, Yipeng
AU  - Song Y
AD  - 1 Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao 
      University, Yantai, Shandong Province, P.R. China.
FAU - Zhang, Zicheng
AU  - Zhang Z
AD  - 2 Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R. China.
FAU - Fu, Chengrui
AU  - Fu C
AD  - 2 Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn337 microRNA, human)
RN  - 0 (Sp1 Transcription Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Movement/genetics
MH  - Cell Proliferation/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - HeLa Cells
MH  - Humans
MH  - Lymphatic Metastasis
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Sp1 Transcription Factor/*biosynthesis
MH  - Uterine Cervical Neoplasms/*genetics/pathology
OTO - NOTNLM
OT  - MicroRNA-337
OT  - cell invasion
OT  - cell proliferation
OT  - cervical cancer
OT  - specificity protein 1
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/24 06:00
AID - 10.1177/1010428317711323 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317711323. doi: 10.1177/1010428317711323.