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Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer 
and Its Clinical Significance.

Abstract The expression of long noncoding RNA HOX antisense RNA (HOTAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title zhongguo fei ai za zhi = chinese journal of lung cancer
Publication Year Start




PMID- 28641698
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170630
LR  - 20170630
IS  - 1999-6187 (Electronic)
IS  - 1009-3419 (Linking)
VI  - 20
IP  - 6
DP  - 2017 Jun 20
TI  - [Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer and Its Clinical
      Significance].
PG  - 402-406
LID - 10.3779/j.issn.1009-3419.2017.06.06 [doi]
AB  - BACKGROUND: The expression of long noncoding RNA HOX antisense RNA (HOTAIR) is
      abnormal in a variety of tumors. The aim of this study is to explore the serum
      levels and clinical significance of HOTAIR in patients with non-small cell lung
      cancer (NSCLC). METHODS: The serum levels of HOTAIR were detected by real-time
      quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal
      controls. The relationships between the serum levels of HOTAIR and clinical
      pathological parameters were analyzed. RESULTS: Compared with normal controls,
      the serum levels of HOTAIR in patients with NSCLC increased significantly
      (P<0.01). The serum levels of HOTAIR were correlated with tumor size,
      tumor-node-metastasis (TNM) stage and lymph node metastasis (P<0.05), but not
      with age, gender, smoking, differentiation and histology (P>0.05). CONCLUSIONS:
      The serum levels of HOTAIR in patients with NSCLC are significantly higher, and
      HOTAIR may be involved in the pathogenesis of NSCLC.
FAU - Tan, Nan
AU  - Tan N
AD  - Cadre Ward, the First Hospital of Xi'an, Xi'an 710002, China.
FAU - Li, Lihong
AU  - Li L
AD  - Cadre Ward, the First Hospital of Xi'an, Xi'an 710002, China.
FAU - Bai, Lu
AU  - Bai L
AD  - Cadre Ward, the First Hospital of Xi'an, Xi'an 710002, China.
FAU - Zhao, Kun
AU  - Zhao K
AD  - Cadre Ward, the First Hospital of Xi'an, Xi'an 710002, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
RN  - 0 (HOTAIR long untranslated RNA, human)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/blood/*genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/*genetics/metabolism
MH  - Lymphatic Metastasis
MH  - Male
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Long Noncoding/blood/*genetics
EDAT- 2017/06/24 06:00
MHDA- 2017/06/24 06:00
CRDT- 2017/06/24 06:00
AID - 10.3779/j.issn.1009-3419.2017.06.06 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2017 Jun 20;20(6):402-406. doi:
      10.3779/j.issn.1009-3419.2017.06.06.

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