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The Effects of Pleural Plaques on Longitudinal Lung Function in Vermiculite Miners of Libby, Montana.

Abstract This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings.
PMID
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Authors

Mayor MeshTerms

Asbestos, Amphibole

Miners

Occupational Exposure

Keywords

Asbestos

High-resolution computed tomography and pleural plaques

Libby miners

Longitudinal lung function

Pleural plaques

Journal Title the american journal of the medical sciences
Publication Year Start




PMID- 28641716
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170628
LR  - 20170628
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 353
IP  - 6
DP  - 2017 Jun
TI  - The Effects of Pleural Plaques on Longitudinal Lung Function in Vermiculite
      Miners of Libby, Montana.
PG  - 533-542
LID - S0002-9629(17)30200-8 [pii]
LID - 10.1016/j.amjms.2017.03.033 [doi]
AB  - BACKGROUND: This study was conducted to assess associations of pleural plaques
      (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who
      are occupationally exposed to asbestos. High-resolution computed tomography
      (HRCT) was used to identify asbestos-related findings in former Libby vermiculite
      miners. We investigated annual lung function decline in miners with PP only and
      compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs
      from 128 miners were categorized into the following 4 diagnostic groups: (1)
      normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and
      interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21)
      such as rounded atelectasis, diffuse pleural thickening, pleural effusions or
      pulmonary nodules or tumor >1cm in diameter. Random intercept and slope linear
      mixed-effect regression models identified differences in lung function decline
      between miners with asbestos-associated outcomes and those with normal HRCT.
      Models were adjusted for follow-up time, body mass index, smoking status, latent 
      exposure period and employment years. Interactions for smoking status with age
      and smoking status with pleural plaque severity were examined. RESULTS: Miners
      with PP only did not have an accelerated decline in lung function between 40 and 
      80 years. Miners with PP and additional HRCT abnormalities displayed
      significantly accelerated declines in forced expiratory volume in 1 second and
      diffusing capacity of the lungs for carbon monoxide (P = 0.05 and P < 0.01,
      respectively). Plaque severity did not affect lung function decline. However,
      smokers with extensive plaques displayed accelerated loss in diffusing capacity
      of the lungs for carbon monoxide and forced expiratory volume in 1 second when
      compared to nonsmoking miners with mild plaque formation. CONCLUSIONS: PP alone
      did not significantly affect lung function decline in vermiculite miners of
      Libby, Montana.
CI  - Published by Elsevier Inc.
FAU - Clark, Kathleen A
AU  - Clark KA
AD  - Department of Epidemiology and Biostatistics, Arnold School of Public Health,
      University of South Carolina, Columbia, South Carolina. Electronic address:
      [email protected]
FAU - Flynn, J Jay 3rd
AU  - Flynn JJ 3rd
AD  - Health Network America, Tinton Falls, New Jersey.
FAU - Karmaus, Wilfried J J
AU  - Karmaus WJJ
AD  - Division of Epidemiology, Biostatistics and Environmental Health, University of
      Memphis, Memphis, Tennessee.
FAU - Mohr, Lawrence C
AU  - Mohr LC
AD  - Department of Medicine, Medical University of South Carolina, Charleston, South
      Carolina; Department of Public Health Sciences, Medical University of South
      Carolina, Charleston, South Carolina; Environmental Biosciences Program, Medical 
      University of South Carolina, Charleston, South Carolina.
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Aluminum Silicates)
RN  - 0 (Asbestos, Amphibole)
RN  - 1318-00-9 (vermiculite)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Aluminum Silicates
MH  - *Asbestos, Amphibole/toxicity
MH  - Humans
MH  - Longitudinal Studies
MH  - Lung/drug effects/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Miners
MH  - Montana
MH  - *Occupational Exposure
MH  - Pleural Diseases/chemically induced/*physiopathology
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Asbestos
OT  - High-resolution computed tomography and pleural plaques
OT  - Libby miners
OT  - Longitudinal lung function
OT  - Pleural plaques
EDAT- 2017/06/24 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/24 06:00
PHST- 2016/11/21 [received]
PHST- 2017/02/19 [revised]
PHST- 2017/03/20 [accepted]
AID - S0002-9629(17)30200-8 [pii]
AID - 10.1016/j.amjms.2017.03.033 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Jun;353(6):533-542. doi: 10.1016/j.amjms.2017.03.033. Epub
      2017 Apr 6.