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PMID- 28641717
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170628
LR  - 20170628
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 353
IP  - 6
DP  - 2017 Jun
TI  - Soluble CD14 Subtype-A New Biomarker in Predicting the Outcome of Critically Ill 
      Septic Patients.
PG  - 543-551
LID - S0002-9629(17)30207-0 [pii]
LID - 10.1016/j.amjms.2017.03.036 [doi]
AB  - BACKGROUND: We evaluated the role of presepsin (soluble CD14 subtype, sCD14-ST)
      in predicting the outcome of critically ill septic patients in parallel with
      procalcitonin and C-reactive protein. METHODS: This study was an observational,
      prospective study that enrolled 58 surgical and medical intensive care unit
      patients with suspected sepsis. All studied subjects were retrospectively
      stratified into survivors and nonsurvivors based on 28 days survival and
      according to microbiological results in blood culture positive and negative
      groups. Plasma and serum samples from each patient were collected at admission
      (T-0), after 24-48 hours (T-1) and after 7 days (T-2). Statistics were obtained
      using Students t test and ANOVA, as well as Bonferroni post hoc test.
      Receiver-operating characteristic (ROC) analysis was also performed. RESULTS:
      Presepsin levels were significantly higher at T-0 (P = 0.0007), at T-1 (P <
      0.0001) and at T-2 (P < 0.0001) in nonsurvivors versus survivors at the same time
      point. Presepsin concentrations were significantly increased at T-0 (P = 0.0073),
      T1 (P = 0.0111) and T2 (P = 0.0167) in patients with positive blood cultures in
      comparison to patients with negative cultures at the same time. For all time
      periods evaluated, presepsin data from nonsurviving and surviving individuals
      were subjected to ROC analysis that demonstrated an excellent accuracy and
      significant area under the ROC curve (P < 0.0001). Results of multivariate
      analysis indicated presepsin as a predictive independent variable among prognosis
      markers at T-0 (P = 0.016). CONCLUSIONS: Presepsin revealed an optimal prognostic
      performance in patients with severe sepsis and provided interesting diagnostic
      value. Prediction of outcome in critically ill patients is crucial to optimize
      management decisions and level of treatment.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Matera, Giovanni
AU  - Matera G
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy. Electronic address:
      [email protected]
FAU - Quirino, Angela
AU  - Quirino A
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Peronace, Cinzia
AU  - Peronace C
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Settembre, Pio
AU  - Settembre P
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Marano, Vito
AU  - Marano V
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Loria, Maria T
AU  - Loria MT
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Marascio, Nadia
AU  - Marascio N
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Galati, Luisa
AU  - Galati L
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Barreca, Giorgio S
AU  - Barreca GS
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Giancotti, Aida
AU  - Giancotti A
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Amantea, Bruno
AU  - Amantea B
AD  - Intensive Care Unit, Department of Health Sciences, "Magna Graecia," University
      of Catanzaro, Catanzaro, Italy.
FAU - Liberto, Maria C
AU  - Liberto MC
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
FAU - Foca, Alfredo
AU  - Foca A
AD  - Department of Health Sciences, "Magna Graecia," Institute of Clinical
      Microbiology, University of Catanzaro, Catanzaro, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170407
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Antigens, CD14)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (presepsin protein, human)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Antigens, CD14/*blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Calcitonin/*blood
MH  - Critical Illness
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Sepsis/*blood/*diagnosis
OTO - NOTNLM
OT  - CRP
OT  - PCT
OT  - Presepsin
OT  - SOFA score
OT  - Sepsis prognosis
EDAT- 2017/06/24 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/24 06:00
PHST- 2016/10/17 [received]
PHST- 2017/03/08 [revised]
PHST- 2017/03/22 [accepted]
AID - S0002-9629(17)30207-0 [pii]
AID - 10.1016/j.amjms.2017.03.036 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Jun;353(6):543-551. doi: 10.1016/j.amjms.2017.03.036. Epub
      2017 Apr 7.