PubTransformer

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PMID- 28641718
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170628
LR  - 20170628
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 353
IP  - 6
DP  - 2017 Jun
TI  - Alterations in Lipid Profile, Zinc and Copper Levels and Superoxide Dismutase
      Activities in Normal Pregnancy and Preeclampsia.
PG  - 552-558
LID - S0002-9629(17)30158-1 [pii]
LID - 10.1016/j.amjms.2017.03.022 [doi]
AB  - BACKGROUND: Increased oxidative stress (OS) and lipid peroxidation may be
      involved in the pathogenesis of preeclampsia (PE). We conducted a case-control
      study to evaluate the levels of plasma lipids and trace elements as well as
      activity of superoxide dismutase (SOD) in PE. MATERIALS AND METHODS: The study
      consisted of 100 patients who had been diagnosed with PE and 100 normotensive
      pregnant women who underwent medical checkups that served as the control group.
      Lipid profile, zinc (Zn) and copper (Cu) levels and SOD activities were measured 
      in the plasma of all subjects. RESULTS: Our results showed that the plasma levels
      of triglycerides and SOD activity were significantly elevated and the levels of
      Zn and Cu were significantly reduced in patients with PE compared with healthy
      controls. Increased levels of SOD may indicate antioxidant protective mechanisms 
      against OS in PE-complicated pregnancies. This finding may suggest an involvement
      of OS in the pathophysiology of PE. CONCLUSION: This study demonstrated a
      significant negative correlation between SOD activity and levels of trace
      elements. Furthermore, we suggest that higher triglyceride levels and SOD
      activity combined with lower Zn and Cu levels may be associated with an increased
      risk of PE.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Keshavarz, Pardis
AU  - Keshavarz P
AD  - Department of Nutrition, Nutrition Research Center, School of Medicine, Mashhad
      University of Medical Sciences, Mashhad, Iran.
FAU - Nobakht M Gh, B Fatemeh
AU  - Nobakht M Gh BF
AD  - Department of Basic Medical Sciences, Neyshabur University of Medical Sciences,
      Neyshabur, Iran.
FAU - Mirhafez, Seyed Reza
AU  - Mirhafez SR
AD  - Department of Basic Medical Sciences, Neyshabur University of Medical Sciences,
      Neyshabur, Iran.
FAU - Nematy, Mohsen
AU  - Nematy M
AD  - Department of Nutrition, Nutrition Research Center, School of Medicine, Mashhad
      University of Medical Sciences, Mashhad, Iran.
FAU - Azimi-Nezhad, Mohsen
AU  - Azimi-Nezhad M
AD  - Department of Basic Medical Sciences, Neyshabur University of Medical Sciences,
      Neyshabur, Iran; (double dagger)Department of Medical Genetics, School of
      Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic
      address: [email protected]
FAU - Afin, Sedigheh Ayati
AU  - Afin SA
AD  - Women Health Research Center, Mashhad University of Medical Sciences, Mashhad,
      Iran.
FAU - Esmaily, Habibollah
AU  - Esmaily H
AD  - Department of Biostatistics and Epidemiology, Health Sciences Research Center,
      School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Pourali, Leila
AU  - Pourali L
AD  - Women Health Research Center, Mashhad University of Medical Sciences, Mashhad,
      Iran.
FAU - Hakak, Atieh Mehdizadeh
AU  - Hakak AM
AD  - Department of Nutrition, Nutrition Research Center, School of Medicine, Mashhad
      University of Medical Sciences, Mashhad, Iran.
FAU - Soukhtanloo, Mohammad
AU  - Soukhtanloo M
AD  - Department of Biochemistry, School of Medicine, Mashhad University of Medical
      Sciences, Mashhad, Iran.
FAU - Mirteimouri, Masoumeh
AU  - Mirteimouri M
AD  - Women Health Research Center, Mashhad University of Medical Sciences, Mashhad,
      Iran.
FAU - Ghomian, Nayereh
AU  - Ghomian N
AD  - Women Health Research Center, Mashhad University of Medical Sciences, Mashhad,
      Iran.
FAU - Ferns, Gordon A
AU  - Ferns GA
AD  - Division of Medical Education, Brighton & Sussex Medical School, Falmer,
      Brighton, UK.
LA  - eng
PT  - Journal Article
DEP - 20170316
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Antioxidants)
RN  - 789U1901C5 (Copper)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - J41CSQ7QDS (Zinc)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Case-Control Studies
MH  - Copper/*blood
MH  - Female
MH  - Humans
MH  - Iran
MH  - *Lipid Peroxidation
MH  - Oxidative Stress
MH  - Pre-Eclampsia/*blood/etiology
MH  - Pregnancy
MH  - Superoxide Dismutase/*blood
MH  - Young Adult
MH  - Zinc/*blood
OTO - NOTNLM
OT  - Lipid profile
OT  - Preeclampsia
OT  - Superoxide dismutase
OT  - Trace element
EDAT- 2017/06/24 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/24 06:00
PHST- 2016/11/05 [received]
PHST- 2017/02/17 [revised]
PHST- 2017/03/13 [accepted]
AID - S0002-9629(17)30158-1 [pii]
AID - 10.1016/j.amjms.2017.03.022 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Jun;353(6):552-558. doi: 10.1016/j.amjms.2017.03.022. Epub
      2017 Mar 16.