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Left Main Coronary Artery Thrombosis With Acute Myocardial Infarction: A Management Dilemma.

Abstract Left main coronary artery (LMCA) thrombosis with acute myocardial infarction is a rare condition with very high mortality. The low incidence of this condition and exclusion of patients with LMCA thrombosis from clinical trials prevent the development of optimal management strategy in these patients. Therefore, there are no clear-cut guidelines describing an evidence-based approach for this condition. We describe a patient with LMCA thrombosis presenting with acute myocardial infarction, who was found to have hypercoagulable state related to homocysteinemia on further work-up. This case highlights the challenges faced during the management of this rare condition due to lack of clear-cut guidelines describing an evidence-based approach.
PMID
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Authors

Mayor MeshTerms
Keywords

Acute myocardial infarction

Left main coronary artery thrombosis

Journal Title the american journal of the medical sciences
Publication Year Start




PMID- 28641723
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170628
LR  - 20170628
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 353
IP  - 6
DP  - 2017 Jun
TI  - Left Main Coronary Artery Thrombosis With Acute Myocardial Infarction: A
      Management Dilemma.
PG  - 597-602
LID - S0002-9629(16)30341-X [pii]
LID - 10.1016/j.amjms.2016.04.022 [doi]
AB  - Left main coronary artery (LMCA) thrombosis with acute myocardial infarction is a
      rare condition with very high mortality. The low incidence of this condition and 
      exclusion of patients with LMCA thrombosis from clinical trials prevent the
      development of optimal management strategy in these patients. Therefore, there
      are no clear-cut guidelines describing an evidence-based approach for this
      condition. We describe a patient with LMCA thrombosis presenting with acute
      myocardial infarction, who was found to have hypercoagulable state related to
      homocysteinemia on further work-up. This case highlights the challenges faced
      during the management of this rare condition due to lack of clear-cut guidelines 
      describing an evidence-based approach.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Arora, Natasha Purai
AU  - Arora NP
AD  - Division of Cardiology, St. John Hospital & Medical Center, Detroit, Michigan.
      Electronic address: [email protected]
FAU - Joumaa, Mouhammed
AU  - Joumaa M
AD  - Division of Cardiology, St. John Hospital & Medical Center, Detroit, Michigan.
FAU - Rosman, Howard
AU  - Rosman H
AD  - Division of Cardiology, St. John Hospital & Medical Center, Detroit, Michigan.
FAU - Mehta, Raj
AU  - Mehta R
AD  - Division of Cardiology, St. John Hospital & Medical Center, Detroit, Michigan.
LA  - eng
PT  - Journal Article
DEP - 20160616
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - AIM
SB  - IM
MH  - Acute Disease
MH  - Coronary Thrombosis/*diagnosis/diagnostic imaging/etiology
MH  - Coronary Vessels/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/diagnostic imaging/etiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Left main coronary artery thrombosis
EDAT- 2017/06/24 06:00
MHDA- 2017/06/29 06:00
CRDT- 2017/06/24 06:00
PHST- 2016/03/17 [received]
PHST- 2016/04/13 [accepted]
AID - S0002-9629(16)30341-X [pii]
AID - 10.1016/j.amjms.2016.04.022 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Jun;353(6):597-602. doi: 10.1016/j.amjms.2016.04.022. Epub
      2016 Jun 16.