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Long non-coding RNAs: New biomarkers for prognosis and diagnosis of colon cancer.

Abstract Dysregulation of long non-coding RNAs has been found in many human cancers, including colorectal cancer that is still the third most prevalent cancer worldwide and related to poor prognosis; along with this, robust testimony has identified that long non-coding RNAs can take charge of tumor suppressor genes or oncogenes. This review summarizes nowadays research achievements on the character of long non-coding RNAs in the prognosis and diagnosis of colorectal cancer. On the basis of the results acquired in the last decade, some long non-coding RNAs are rising as biomarkers of colorectal cancer for prognosis, diagnosis, even prediction of therapeutic result, and have crucial effects in the regulation of colorectal cancer cell functions such as proliferation, invasion, apoptosis, metastasis, and drug resistant ability. Also, long non-coding RNAs, circulating in body fluids, could act as novel, affordable, lightly accessible, non-invasive detection tools for the personal health management of patients with colorectal cancer. Especially, circulating long non-coding RNA profiles may be demonstrating preferable prognostic and diagnostic capability and better accuracy than respective long non-coding RNAs in colorectal cancer.
PMID
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Authors

Mayor MeshTerms

Prognosis

Keywords

Long non-coding RNA

biomarker

colorectal cancer

diagnosis

prognosis

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28643604
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170711
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Long non-coding RNAs: New biomarkers for prognosis and diagnosis of colon cancer.
PG  - 1010428317706332
LID - 10.1177/1010428317706332 [doi]
AB  - Dysregulation of long non-coding RNAs has been found in many human cancers,
      including colorectal cancer that is still the third most prevalent cancer
      worldwide and related to poor prognosis; along with this, robust testimony has
      identified that long non-coding RNAs can take charge of tumor suppressor genes or
      oncogenes. This review summarizes nowadays research achievements on the character
      of long non-coding RNAs in the prognosis and diagnosis of colorectal cancer. On
      the basis of the results acquired in the last decade, some long non-coding RNAs
      are rising as biomarkers of colorectal cancer for prognosis, diagnosis, even
      prediction of therapeutic result, and have crucial effects in the regulation of
      colorectal cancer cell functions such as proliferation, invasion, apoptosis,
      metastasis, and drug resistant ability. Also, long non-coding RNAs, circulating
      in body fluids, could act as novel, affordable, lightly accessible, non-invasive 
      detection tools for the personal health management of patients with colorectal
      cancer. Especially, circulating long non-coding RNA profiles may be demonstrating
      preferable prognostic and diagnostic capability and better accuracy than
      respective long non-coding RNAs in colorectal cancer.
FAU - Deng, Heng
AU  - Deng H
AD  - 1 Graduate School, Anhui University of Traditional Chinese Medicine, Hefei,
      China.
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
AD  - 3 The People's Hospital of Susong, Susong, China.
FAU - Wang, Jian Min
AU  - Wang JM
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
FAU - Li, Ming
AU  - Li M
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
FAU - Tang, Ran
AU  - Tang R
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
FAU - Tang, Kun
AU  - Tang K
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
FAU - Su, Yingzi
AU  - Su Y
AD  - 1 Graduate School, Anhui University of Traditional Chinese Medicine, Hefei,
      China.
FAU - Hou, Yong
AU  - Hou Y
AD  - 2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui
      University of Traditional Chinese Medicine, Hefei, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - 1 Graduate School, Anhui University of Traditional Chinese Medicine, Hefei,
      China.
AD  - 4 Surgery of Traditional Chinese Medicine Research Institute, Anhui University of
      Traditional Chinese Medicine, Hefei, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Apoptosis/genetics
MH  - Biomarkers, Tumor/*genetics
MH  - Colonic Neoplasms/diagnosis/*genetics/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Prognosis
MH  - RNA, Long Noncoding/*genetics
OTO - NOTNLM
OT  - Long non-coding RNA
OT  - biomarker
OT  - colorectal cancer
OT  - diagnosis
OT  - prognosis
EDAT- 2017/06/24 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/24 06:00
AID - 10.1177/1010428317706332 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317706332. doi: 10.1177/1010428317706332.