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Blood lead levels and risk factors for lead exposure among pregnant women in western French Guiana: the role of manioc consumption.

Abstract Concerns regarding lead (Pb) poisoning in French Guiana first arose in 2011 following the discovery of excessively high levels of the metal amongst children in a small neighborhood without any apparent source of Pb. Since 2012, blood lead level (BLL) measurement has been proposed for all pregnant women in western French Guiana. The aim of this study was to determine BLL in pregnant women in this region and identify factors associated with elevated BLL. An observational study of a consecutive sample of women who delivered in the maternity ward of the hospital was conducted. Risk factors were investigated using a questionnaire administered postdelivery by midwives (N = 531). Approximately 25 and 5% of women displayed BLL of ≥50 μg/L and ≥100 µg/L, respectively. The geometric mean was 32.6 μg/L. Factors that were significantly associated with an elevated BLL after modeling (multivariate linear regression) included place of residence along the Maroni river, low level of education, daily consumption of manioc derivatives, weekly and daily consumption or personal preparation of manioc flour during pregnancy, and weekly consumption of wild game. This study provides insight into the regional and social disparities in BLL in French Guiana and potential sources of exposure. Evidence indicates that foods that are primarily produced and consumed in the Guiana Shield significantly affect BLL levels. Taken together with existing data, our results demonstrate that specific actions in terms of prevention, screening, and care are required to be adapted and put into place in order to reduce exposure.
PMID
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Authors

Mayor MeshTerms

Diet

Environmental Exposure

Keywords
Journal Title journal of toxicology and environmental health. part a
Publication Year Start




PMID- 28644767
OWN - NLM
STAT- MEDLINE
DA  - 20170623
DCOM- 20170714
LR  - 20170714
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 80
IP  - 6
DP  - 2017
TI  - Blood lead levels and risk factors for lead exposure among pregnant women in
      western French Guiana: the role of manioc consumption.
PG  - 382-393
LID - 10.1080/15287394.2017.1331490 [doi]
AB  - Concerns regarding lead (Pb) poisoning in French Guiana first arose in 2011
      following the discovery of excessively high levels of the metal amongst children 
      in a small neighborhood without any apparent source of Pb. Since 2012, blood lead
      level (BLL) measurement has been proposed for all pregnant women in western
      French Guiana. The aim of this study was to determine BLL in pregnant women in
      this region and identify factors associated with elevated BLL. An observational
      study of a consecutive sample of women who delivered in the maternity ward of the
      hospital was conducted. Risk factors were investigated using a questionnaire
      administered postdelivery by midwives (N = 531). Approximately 25 and 5% of women
      displayed BLL of >/=50 mug/L and >/=100 microg/L, respectively. The geometric
      mean was 32.6 mug/L. Factors that were significantly associated with an elevated 
      BLL after modeling (multivariate linear regression) included place of residence
      along the Maroni river, low level of education, daily consumption of manioc
      derivatives, weekly and daily consumption or personal preparation of manioc flour
      during pregnancy, and weekly consumption of wild game. This study provides
      insight into the regional and social disparities in BLL in French Guiana and
      potential sources of exposure. Evidence indicates that foods that are primarily
      produced and consumed in the Guiana Shield significantly affect BLL levels. Taken
      together with existing data, our results demonstrate that specific actions in
      terms of prevention, screening, and care are required to be adapted and put into 
      place in order to reduce exposure.
FAU - Rimbaud, Diane
AU  - Rimbaud D
AD  - a Department of Public Health , Centre Hospitalier de l'Ouest Guyanais ,
      Saint-Laurent du Maroni , French Guiana.
FAU - Restrepo, Marion
AU  - Restrepo M
AD  - a Department of Public Health , Centre Hospitalier de l'Ouest Guyanais ,
      Saint-Laurent du Maroni , French Guiana.
FAU - Louison, Anne
AU  - Louison A
AD  - b Reseau Perinat-Guyane , Cayenne , French Guiana.
FAU - Boukhari, Rachida
AU  - Boukhari R
AD  - c Department of Clinical Biology , Centre Hospitalier de l'Ouest Guyanais ,
      Saint-Laurent du Maroni , French Guiana.
FAU - Ardillon, Vanessa
AU  - Ardillon V
AD  - d CIRE Antilles-Guyane , Cayenne , French Guiana.
FAU - Carles, Gabriel
AU  - Carles G
AD  - e Department of Obstetrics & Gynecology , Centre Hospitalier de l'Ouest Guyanais 
      , Saint-Laurent du Maroni , French Guiana.
FAU - Lambert, Veronique
AU  - Lambert V
AD  - e Department of Obstetrics & Gynecology , Centre Hospitalier de l'Ouest Guyanais 
      , Saint-Laurent du Maroni , French Guiana.
FAU - Jolivet, Anne
AU  - Jolivet A
AUID- ORCID: http://orcid.org/0000-0001-6233-1225
AD  - a Department of Public Health , Centre Hospitalier de l'Ouest Guyanais ,
      Saint-Laurent du Maroni , French Guiana.
AD  - f Department of Social Epidemiology, Sorbonne Universites , UPMC Univ Paris 06,
      INSERM, Institut Pierre Louis d'epidemiologie et de Sante Publique (IPLESP UMRS
      1136) , Paris , France.
LA  - eng
PT  - Journal Article
DEP - 20170623
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Diet
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Female
MH  - French Guiana
MH  - Humans
MH  - Lead Poisoning/*blood
MH  - Manihot/*chemistry
MH  - Pregnancy
MH  - Risk Factors
MH  - Young Adult
EDAT- 2017/06/24 06:00
MHDA- 2017/07/15 06:00
CRDT- 2017/06/24 06:00
AID - 10.1080/15287394.2017.1331490 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2017;80(6):382-393. doi:
      10.1080/15287394.2017.1331490. Epub 2017 Jun 23.