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Muscle strength and control characteristics are altered by peripheral artery disease.

Abstract Peripheral artery disease (PAD), a common manifestation of atherosclerosis, is characterized by lower leg ischemia and myopathy in association with leg dysfunction. Patients with PAD have impaired gait from the first step they take with consistent defects in the movement around the ankle joint, especially in plantar flexion. Our goal was to develop muscle strength profiles to better understand the problems in motor control responsible for the walking impairment in patients with PAD.
PMID
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Authors

Mayor MeshTerms

Isometric Contraction

Muscle Strength

Keywords
Journal Title journal of vascular surgery
Publication Year Start




PMID- 28647034
OWN - NLM
STAT- MEDLINE
DA  - 20170625
DCOM- 20170710
LR  - 20170714
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 66
IP  - 1
DP  - 2017 Jul
TI  - Muscle strength and control characteristics are altered by peripheral artery
      disease.
PG  - 178-186.e12
LID - S0741-5214(17)30352-X [pii]
LID - 10.1016/j.jvs.2017.01.051 [doi]
AB  - OBJECTIVE: Peripheral artery disease (PAD), a common manifestation of
      atherosclerosis, is characterized by lower leg ischemia and myopathy in
      association with leg dysfunction. Patients with PAD have impaired gait from the
      first step they take with consistent defects in the movement around the ankle
      joint, especially in plantar flexion. Our goal was to develop muscle strength
      profiles to better understand the problems in motor control responsible for the
      walking impairment in patients with PAD. METHODS: Ninety-four claudicating PAD
      patients performed maximal isometric plantar flexion contractions lasting 10
      seconds in two conditions: pain free (patient is well rested and has no
      claudication symptoms) and pain induced (patient has walked and has claudication 
      symptoms). Sixteen matched healthy controls performed the pain-free condition
      only. Torque curves were analyzed for dependent variables of muscle strength and 
      motor control. Independent t-tests were used to compare variables between groups,
      and dependent t-tests determined differences between conditions. RESULTS:
      Patients with PAD had significantly reduced peak torque and area under the curve 
      compared with controls. Measures of control differed between PAD conditions only.
      Load rate and linear region duration were greater in the pain condition. Time to 
      peak torque was shorter in the pain condition. CONCLUSIONS: This study
      conclusively demonstrates that the plantar flexor muscles of the PAD patient at
      baseline and without pain are weaker in patients with PAD compared with controls.
      With the onset of claudication pain, patients with PAD exhibit altered muscle
      control strategies and further strength deficits are manifest compared to
      baseline levels. The myopathy of PAD legs appears to have a central role in the
      functional deterioration of the calf muscles, as it is evident both before and
      after onset of ischemic pain.
CI  - Copyright (c) 2017 Society for Vascular Surgery. Published by Elsevier Inc. All
      rights reserved.
FAU - Schieber, Molly N
AU  - Schieber MN
AD  - Department of Biomechanics, University of Nebraska at Omaha, Omaha, Neb.
FAU - Hasenkamp, Ryan M
AU  - Hasenkamp RM
AD  - Department of Biomechanics, University of Nebraska at Omaha, Omaha, Neb.
FAU - Pipinos, Iraklis I
AU  - Pipinos II
AD  - Department of Surgery, Veterans Affairs Medical Center of Nebraska and Western
      Iowa, Omaha, Neb; Department of Surgery, University of Nebraska Medical Center,
      Omaha, Neb.
FAU - Johanning, Jason M
AU  - Johanning JM
AD  - Department of Surgery, Veterans Affairs Medical Center of Nebraska and Western
      Iowa, Omaha, Neb; Department of Surgery, University of Nebraska Medical Center,
      Omaha, Neb.
FAU - Stergiou, Nicholas
AU  - Stergiou N
AD  - Department of Biomechanics, University of Nebraska at Omaha, Omaha, Neb; College 
      of Public Health, University of Nebraska Medical Center, Omaha, Neb.
FAU - DeSpiegelaere, Holly K
AU  - DeSpiegelaere HK
AD  - Department of Surgery, Veterans Affairs Medical Center of Nebraska and Western
      Iowa, Omaha, Neb.
FAU - Chien, Jung H
AU  - Chien JH
AD  - Department of Physical Therapy Education, University of Nebraska Medical Center, 
      Omaha, Neb.
FAU - Myers, Sara A
AU  - Myers SA
AD  - Department of Biomechanics, University of Nebraska at Omaha, Omaha, Neb;
      Department of Surgery, Veterans Affairs Medical Center of Nebraska and Western
      Iowa, Omaha, Neb. Electronic address: [email protected]
LA  - eng
GR  - R01 AG034995/AG/NIA NIH HHS/United States
GR  - R01 HD090333/HD/NICHD NIH HHS/United States
GR  - P20 GM109090/GM/NIGMS NIH HHS/United States
GR  - I01 RX000604/RX/RRD VA/United States
GR  - R01 AG049868/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Intermittent Claudication/diagnosis/*physiopathology
MH  - *Isometric Contraction
MH  - Linear Models
MH  - Lower Extremity
MH  - Male
MH  - Middle Aged
MH  - Motor Activity
MH  - *Muscle Strength
MH  - Muscle, Skeletal/*blood supply/*physiopathology
MH  - Peripheral Arterial Disease/diagnosis/*physiopathology
MH  - Prospective Studies
MH  - ROC Curve
MH  - Time Factors
MH  - Torque
PMC - PMC5484068
MID - NIHMS857812
EDAT- 2017/06/26 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/26 06:00
PMCR- 2018/07/01
PHST- 2016/11/07 [received]
PHST- 2017/01/31 [accepted]
AID - S0741-5214(17)30352-X [pii]
AID - 10.1016/j.jvs.2017.01.051 [doi]
PST - ppublish
SO  - J Vasc Surg. 2017 Jul;66(1):178-186.e12. doi: 10.1016/j.jvs.2017.01.051.