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Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma.

Abstract PTOV1 has been demonstrated to play an extensive role in many types of cancers. This study takes the first step to clarify the potential relationship between esophageal squamous cell carcinoma and PTOV1 expression and highlight the link between PTOV1 and the tumorigenesis, progression, and prognosis of esophageal squamous cell carcinoma. PTOV1 expression was detected by quantitative reverse transcription polymerase chain reaction and western blotting or immunohistochemical staining in esophageal squamous cell carcinoma cell lines, esophageal squamous cell carcinoma tissues, and its paired adjacent non-cancerous tissues. Moreover, we have analyzed the relationship between PTOV1 expression and clinicopathological features of esophageal squamous cell carcinoma. Survival analysis and Cox regression analysis were used to assess its prognostic significance. We found that PTOV1 expression was significantly higher in the esophageal squamous cell carcinoma cell lines and tissues at messenger RNA level (p < 0.001) and protein level (p < 0.001). Gender, tumor size, or differentiation was tightly associated with the PTOV1 expression. Lymph node involvement (p < 0.001) and TNM stage (p < 0.001) promoted a high PTOV1 expression. A prognostic significance of PTOV1 was also found by Log-rank method, and the overexpression of PTOV1 was related to a shorter OS and DFS. Multiple Cox regression analysis indicated overexpressed PTOV1 as an independent indicator for adverse prognosis. In conclusion, this study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma.
PMID
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Authors

Mayor MeshTerms

Prognosis

Keywords

PTOV1

esophageal squamous cell carcinoma

prognosis

progression

tumorigenesis

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28651486
OWN - NLM
STAT- MEDLINE
DA  - 20170627
DCOM- 20170710
LR  - 20170713
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal
      squamous cell carcinoma.
PG  - 1010428317705013
LID - 10.1177/1010428317705013 [doi]
AB  - PTOV1 has been demonstrated to play an extensive role in many types of cancers.
      This study takes the first step to clarify the potential relationship between
      esophageal squamous cell carcinoma and PTOV1 expression and highlight the link
      between PTOV1 and the tumorigenesis, progression, and prognosis of esophageal
      squamous cell carcinoma. PTOV1 expression was detected by quantitative reverse
      transcription polymerase chain reaction and western blotting or
      immunohistochemical staining in esophageal squamous cell carcinoma cell lines,
      esophageal squamous cell carcinoma tissues, and its paired adjacent non-cancerous
      tissues. Moreover, we have analyzed the relationship between PTOV1 expression and
      clinicopathological features of esophageal squamous cell carcinoma. Survival
      analysis and Cox regression analysis were used to assess its prognostic
      significance. We found that PTOV1 expression was significantly higher in the
      esophageal squamous cell carcinoma cell lines and tissues at messenger RNA level 
      (p &lt; 0.001) and protein level (p &lt; 0.001). Gender, tumor size, or differentiation
      was tightly associated with the PTOV1 expression. Lymph node involvement (p &lt;
      0.001) and TNM stage (p &lt; 0.001) promoted a high PTOV1 expression. A prognostic
      significance of PTOV1 was also found by Log-rank method, and the overexpression
      of PTOV1 was related to a shorter OS and DFS. Multiple Cox regression analysis
      indicated overexpressed PTOV1 as an independent indicator for adverse prognosis. 
      In conclusion, this study takes the lead to demonstrate that the overexpressed
      PTOV1 plays a vital role in the tumorigenesis and progression of esophageal
      squamous cell carcinoma, and it is potentially a valuable prognostic predicator
      and new chemotherapeutic target for esophageal squamous cell carcinoma.
FAU - Li, Rong
AU  - Li R
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Leng, Ai-Min
AU  - Leng AM
AD  - 3 Department of Gastroenterology, Xiangya Hospital of Central South University,
      Changsha, People's Republic of China.
FAU - Liu, Xiao-Ming
AU  - Liu XM
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Hu, Ting-Zi
AU  - Hu TZ
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Zhang, Lin-Fang
AU  - Zhang LF
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Li, Ming
AU  - Li M
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Jiang, Xiao-Xia
AU  - Jiang XX
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
FAU - Zhou, Yan-Wu
AU  - Zhou YW
AD  - 4 Department of Thoracic Surgery, Xiangya Hospital of Central South University,
      Changsha, People's Republic of China.
FAU - Xu, Can-Xia
AU  - Xu CX
AD  - 1 Department of Gastroenterology, Third Xiangya Hospital of Central South
      University, Changsha, People's Republic of China.
AD  - 2 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha,
      People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PTOV1 protein, human)
RN  - Esophageal Squamous Cell Carcinoma
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis/*genetics
MH  - Carcinogenesis/*genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Esophageal Neoplasms/*genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Neoplasm Proteins/biosynthesis/*genetics
MH  - Neoplasm Staging
MH  - *Prognosis
OTO - NOTNLM
OT  - PTOV1
OT  - esophageal squamous cell carcinoma
OT  - prognosis
OT  - progression
OT  - tumorigenesis
EDAT- 2017/06/28 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/06/28 06:00
AID - 10.1177/1010428317705013 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jun;39(6):1010428317705013. doi: 10.1177/1010428317705013.